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A method for preparing folic acid

A folic acid and sulfate technology, applied in the field of medicine, can solve the problems of increasing labor intensity and production cost, cumbersome refining process, low total yield, etc., and achieves the effects of short reaction time, avoiding a large amount of waste water and high product purity

Active Publication Date: 2019-07-12
CHANGZHOU PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The existing folic acid preparation method uses sodium acetate to adjust the pH value of the reaction system to maintain around 3.0. Because the reaction process generates hydrochloric acid, the acidity is too strong, and sodium acetate belongs to strong base and weak acid salt, the consumption is relatively large, and the price is relatively high. Invisibly increase the labor intensity and production cost of workers
In addition, the existing preparation method uses water as a solvent, has many side reactions, and the follow-up refining process is cumbersome, resulting in a low overall yield and a large amount of waste water, which brings great pressure to the environment.

Method used

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  • A method for preparing folic acid
  • A method for preparing folic acid
  • A method for preparing folic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Feeding ratio:

[0025]

[0026] Steps:

[0027] Add 100g N-p-aminobenzoyl glutamic acid, 120g 2,4,5-triamino-6-hydroxypyrimidine sulfate in the reaction flask, 160g 1,1,3-trichloroacetone, 140g sodium metabisulfite, 100g 1 -Ethyl-3-methylimidazolium tetrafluoroborate ([emim]BF4), stirring and controlling the temperature at 20-30°C for 2 hours. During the reaction, use sodium hydroxide to adjust the pH value of the system to 3.0-3.5, and stop after the reaction Stir and filter to obtain crude folic acid.

[0028] Add the obtained folic acid crude product and 4.5L purified water into the reaction flask, heat to 80-90°C under stirring, then adjust the pH of the system to 8-9 with sodium hydroxide solution (2N), add 15g of activated carbon and keep stirring for 30 minutes to decolorize , hot filter. Control the temperature of the filtrate at 80-90°C, add dilute hydrochloric acid (2N) to adjust the pH to 3.0-3.5, slowly cool down to room temperature, filter, put the f...

Embodiment 2

[0030] Feeding ratio:

[0031]

[0032] Steps:

[0033] Add 100g N-p-aminobenzoyl glutamic acid, 120g 2,4,5-triamino-6-hydroxypyrimidine sulfate in the reaction flask, 160g 1,1,3-trichloroacetone, 140g sodium metabisulfite, 150g 1 -Butyl-3-methylimidazolium hexafluorophosphate ([bmim]PF6), stirring and controlling the temperature at 30-40°C for 1h30min, during the reaction, use potassium hydroxide to adjust the pH value of the system to 4.0-5.0, and stop stirring after the reaction , filtered to obtain crude folic acid.

[0034] Add the obtained folic acid crude product and 4.5L of purified water into the reaction flask, heat to 80-90°C under stirring, then adjust the pH of the system to 8-9 with potassium hydroxide solution (2N), add 15g of activated carbon and keep stirring for 30 minutes to decolorize , hot filter. Control the temperature of the filtrate at 80-90°C, add dilute hydrochloric acid (2N) to adjust the pH to 3.0-3.5, slowly cool down to room temperature, fi...

Embodiment 3

[0036] Feeding ratio:

[0037]

[0038] Steps:

[0039] Add 100g N-p-aminobenzoyl glutamic acid, 160g 2,4,5-triamino-6-hydroxypyrimidine sulfate in the reaction flask, 150g 1,1,3-trichloroacetone, 150g sodium metabisulfite, 80g N -Butylpyridine hexafluorophosphate (BPyPF6), stirring and controlling the temperature at 40-50°C for 2h15min, during the reaction, adjust the pH of the system to 2.0-3.0 with sodium hydroxide, stop stirring after the reaction, and filter to obtain crude folic acid.

[0040] Add the obtained folic acid crude product and 4.5L of purified water into the reaction flask, heat to 80-90°C under stirring, then adjust the pH of the system to 8-9 with sodium carbonate solution (1N), add 15g of activated carbon and keep stirring to decolorize for 30 minutes. hot filter. Control the temperature of the filtrate at 80-90°C, add dilute hydrochloric acid (2N) to adjust the pH to 3.0-3.5, slowly cool down to room temperature, filter, put the filter cake in an ove...

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PUM

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Abstract

The invention discloses a new folic acid preparation method, wherein folic acid is subjected to one-pot low temperature synthesis by using an ion liquid as a solvent. According to the present invention, the reaction condition is mild, the problems of more side reactions, high water consumption and complex refining process of the existing folic acid preparation method using the water as the solvent are solved, and the good foundation is established for the production capacity improving in the industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a new preparation method of folic acid. Background technique [0002] Folic acid (Folic Acid) is also known as vitamin B9 and vitamin M. As a water-soluble B vitamin, it is widely found in fresh green vegetables and fruits. In 1941, American scholar H.K. Mitchell et al. A compound with anti-anemia effect, so it is named folic acid. In 1945, Angier et al. used chemical methods to fully synthesize folic acid and determined its structure. The molecular structure of folic acid contains structural units of pteridine, p-aminobenzoic acid, and L-glutamic acid, so folic acid is called pteroylglutamic acid. Studies have found that folic acid can promote the maturation of young cells in the bone marrow. Humans who lack folic acid It can cause megaloblastic anemia and leukopenia, which is especially important for pregnant women. Clinically, it is mainly used to prevent and tr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D475/04
CPCC07D475/04
Inventor 靳光玉陈永红吴路新
Owner CHANGZHOU PHARMA FACTORY
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