Unlock instant, AI-driven research and patent intelligence for your innovation.
1-(2-pyridine)-9-(2-phenoxy ethyl)-beta-carboline cupric chloride complex, and synthesis method and application thereof
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A synthetic method and compound technology, applied in the field of medicine, can solve problems such as synthetic methods that have not yet been seen
Active Publication Date: 2017-03-08
GUANGXI NORMAL UNIV
View PDF3 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
However, there is no relevant information on copper (II) chloride complexes and their synthetic methods and applications with 1-(2-pyridine)-9-(2-phenoxyethyl)-β-carboline as ligands. to report
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0044] Embodiment 1: The compound shown in formula (II) is the synthesis of 1-(2-pyridine)-9-(2-phenoxyethyl)-β-carboline (L)
[0045] 1) Add 1.6g (10mmol) tryptamine, 1.1g (10mmol) pyridine-2-carbaldehyde and 50ml toluene into a 150ml round bottom flask, add a water separator and a condenser tube to form a component water reflux device, heat and reflux for 4 hours, wait After the reaction, the solvent was evaporated to dryness, and the residue was recrystallized with 100ml of n-hexane to obtain compound 1 (2.3g, yield 92%);
[0057] In step 2), with Mn(Ac) 3 Instead of palladium carbon, glacial acetic acid instead of p-xylene, control Mn(Ac) 3 The amount of compound 1 added was twice that of compound 1, and the reaction was carried out at 70°C. TLC was tracked and detected until the end of the reaction, and then the pH of the system was adjusted to 7 with ammonia water, extracted three times with ethyl acetate, and the organic phases were combined. , evaporate the solvent to dryness, and the resulting residue is applied to a silica gel column (chromatographic purification (V 石油醚 :V 二氯甲烷 =1:1), compound 2 was obtained.
[0058] The product obtained in this example was analyzed by H NMR, C NMR and high resolutionmass spectrometry, and it was determined to be the target product 1-(2-pyridine)-9-(2-phenoxyethyl)-β-carboline.
Embodiment 3
[0059] Embodiment 3: the synthesis of ligand L
[0060] Repeat Example 2, the difference is:
[0061] In step 2), with Pb(Ac) 4 instead of Mn(Ac) 3 , to control Pb(Ac) 4 The amount of added is 5 times the amount of compound 1, and the reaction is carried out at 60°C.
[0062] The product obtained in this example was analyzed by H NMR, C NMR and high resolutionmass spectrometry, and it was determined to be the target product 1-(2-pyridine)-9-(2-phenoxyethyl)-β-carboline.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Login to View More
Abstract
The invention discloses a 1-(2-pyridine)-9-(2-phenoxy ethyl)-beta-carboline cupric chloride complex, and a synthesis method and application thereof. A structure formula of the complex is shown in a formula (I), and the synthesis method comprises the following steps: dissolving a compound shown in a formula (II) and cupric chloride in a polar solvent, and carrying out a coordination reaction to obtain a product. The polar solvent is a combination of one or more selected from methanol and ethanol, and one or more than two selected from water, acetone, chloroform, dichloromethane and N,N-dimethylformamide. The 1-(2-pyridine)-9-(2-phenoxy ethyl)-beta-carboline cupric chloride complex has stronger antitumor activity than ligand and cisplatin and good potential medicinal value, and is expected to be used for the preparation of various anticancer drugs. The structures of the formulas (I) and (II) are shown as follows.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to a copperchloride complex of 1-(2-pyridine)-9-(2-phenoxyethyl)-β-carboline, a synthesis method and an application. Background technique [0002] β-carbolines are a class of alkaloids widely distributed in nature, and they mainly exist in a variety of terrestrial plants and marine organisms. In terms of chemical structure, β-carboline alkaloids belong to indole alkaloids, which are tricyclic ring systems composed of indolopyridines. Atoms exist in different hybridization states, the nitrogen atom at position 9 is sp 3 Hybridization, rich π-electronsystem, 2-position nitrogen atom is sp 2 Hybridization is a π-electron-deficient system. The two nitrogen atoms are closely related to the chemical properties and biological activities of these compounds. Such compounds have a wide range of biological and pharmacological activities, including: sedative, anxiolytic, hypnotic, antisp...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More 
Login to View More