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Tissue restoration fiber membrane, production method and application thereof, and tissue restoration product

A tissue repair and fibrous membrane technology, applied in tissue regeneration, textile and papermaking, fabric surface trimming, etc., can solve the problem that the performance of repairing fibrous membrane is not ideal, prone to foreign body sensation and pain, cell growth or slow growth, etc. The problem is that it is easy to achieve product standards, facilitate cell adhesion, and achieve the effect of tissue regeneration.

Active Publication Date: 2017-03-15
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1) Woven mesh is currently the most widely used product in fiber membranes for tissue repair, but this type of product has a rough surface, a hard texture, cannot be degraded in vivo, has poor biocompatibility, is prone to foreign body sensation and pain, and causes common erosion and Complications such as infection; and the immune rejection caused by this type of material is strong, and there are many sequelae of surgery; when it is in direct contact with internal organs and organs, it is easy to cause damage, which can cause serious adhesions, serious foreign bodies and immune reaction, requiring secondary surgery to remove, causing pain to the patient and even life-threatening
[0005] 2) The electrospun membrane prepared by the traditional process has a single structure, a hard texture, a dense texture, difficult or slow growth of cells into the interior, and poor clinical satisfaction.
[0006] It can be seen that the performance of the fiber membrane for tissue repair formed by the existing weaving and electrospinning technology is not ideal.

Method used

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  • Tissue restoration fiber membrane, production method and application thereof, and tissue restoration product
  • Tissue restoration fiber membrane, production method and application thereof, and tissue restoration product
  • Tissue restoration fiber membrane, production method and application thereof, and tissue restoration product

Examples

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preparation example Construction

[0058] As a preferred preparation method of the fiber membrane for tissue repair of the present invention, it specifically includes the following steps:

[0059] (1) dissolving the fiber silk material in a solvent to obtain a fiber silk material solution;

[0060] (2) Load the fiber filament material solution obtained in step (1) into an electrospinning syringe, perform electrospinning, and receive the fiber filament into a film-like structure to obtain a fiber membrane;

[0061] (3) Four sides of the fibrous membrane prepared in step (2) are fixed, and then vacuum-dried and shaped at 30-60° C. with a vacuum degree of -0.06 to -0.12 MPa to obtain a fibrous membrane for tissue repair.

[0062] In the above step (3), the setting is carried out at 30-60°C, preferably at 35-55°C.

[0063] And before the setting in step (3), the fibrous membrane is soaked with a solvent different from that in step (1), provided that the fibrous membrane is not completely swollen. Wherein, "comple...

Embodiment 1

[0076] (1) Dissolve PLLA in hexafluoroisopropanol to form a 10.5 g / dL solution.

[0077](2) the solution that obtains in step (1) is contained in the syringe that is connected with high-pressure needle, the receiving distance of adjustment receiving device is 26cm, and the speed that regulation micro-injection pump advances PLLA is 6ml / h, then regulates positive high pressure as 25KV, the negative pressure is 0kv, the rotating roller is used as the receiving device, and the rotation speed is 100rpm, and then the electrospinning is carried out for 6h. After the electrospinning is completed, the membrane material is removed from the roller, and then vacuum-dried to remove the solvent to obtain a fiber membrane.

[0078] (3) Fix the four sides of the membrane material prepared in step (2), and set it at a temperature of 55°C and a vacuum of -0.1MPa for 72 hours to prepare a fiber membrane for tissue repair. The fibers in the fiber membrane for tissue repair The filament has a ri...

Embodiment 2

[0081] (1) Dissolve PLLA in hexafluoroisopropanol to form a 11.5 g / dL solution.

[0082] (2) the solution that obtains in step (1) is contained in the syringe that is connected with high-pressure needle, the receiving distance of adjustment receiving device is 27cm, and the speed that adjustment micro-injection pump advances PLLA is 6.3ml / h, then adjusts positive high pressure It is 24KV, the negative pressure is 0kv, the rotating roller is used as the receiving device, and the rotating speed is 100rpm, and then the electrospinning is carried out for 7h to obtain the fiber film, and then the solvent is removed by vacuum drying for later use.

[0083] (3) Fix the four sides of the film prepared in step (2), infiltrate it with alcohol with a volume concentration of 95% for 5 minutes, and then set it at a temperature of 50°C and a vacuum of -0.098MPa for 48 hours to prepare a tissue repair tissue. Fibrous membrane, the fibrous filaments in the tissue repairing fibrous membrane ha...

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Abstract

The invention relates to a tissue restoration fiber membrane, a production method and an application thereof, and a tissue restoration product. The tissue restoration fiber membrane is formed by interlacing fiber yarns with the diameter of 10 nm to 100 [mu]m, the fiber membrane has a pore structure formed by interlacing the fiber yarns, every fiber yarn is provided with an annular projection structure in a radial direction, and the bulkiness of the fiber membrane is not less than 2 cm<3> / g and less than 200 cm<3> / g. The invention also discloses the production method of the tissue restoration fiber membrane, the application of the tissue restoration fiber membrane in the production of the tissue restoration product, and the tissue restoration product produced by using the fiber membrane.

Description

technical field [0001] The invention relates to a fibrous membrane for tissue repair, a preparation method and application thereof, and a product for tissue repair. Background technique [0002] In modern surgical operations, it is very common to use tissue repair membranes to repair tissues and organs, such as tissue repair membranes in hernia repair, female pelvic floor dysfunction repair, dura / spinal defect repair, nerve conduit defect repair, blood vessel The repair of ligaments, ligament repair, bone defect repair and other applications. Due to the particularity of human tissue structure and function, an ideal fibrous membrane for tissue repair should have the following properties: ①Good biocompatibility, able to guide tissue growth and achieve ideal repair; ②Facilitate cell adhesion, crawling and growth, to achieve tissue regeneration ; ③ a certain strength, able to resist mechanical stress, and provide sufficient mechanical support before the healthy tissue is fully ...

Claims

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Application Information

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IPC IPC(8): A61L27/16A61L27/18A61L27/20A61L27/22A61L27/24A61L27/26A61L27/60D04H1/4382D04H1/728D06C7/02
CPCA61L27/16A61L27/18A61L27/20A61L27/225A61L27/24A61L27/26A61L27/60A61L2430/00A61L2430/02A61L2430/10A61L2430/20A61L2430/32D04H1/4382D04H1/728D06C7/02
Inventor 邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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