Tissue restoration fiber membrane, production method and application thereof, and tissue restoration product

A tissue repair and fibrous membrane technology, applied in tissue regeneration, textile and papermaking, fabric surface trimming, etc., can solve the problem that the performance of repairing fibrous membrane is not ideal, prone to foreign body sensation and pain, cell growth or slow growth, etc. The problem is that it is easy to achieve product standards, facilitate cell adhesion, and achieve the effect of tissue regeneration.

Active Publication Date: 2017-03-15
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1) Woven mesh is currently the most widely used product in fiber membranes for tissue repair, but this type of product has a rough surface, a hard texture, cannot be degraded in vivo, has poor biocompatibility, is prone to foreign body sensation and pain, and causes common erosion and Complications such as infection; and the immune rejection caused by this type of material is strong, and there are many sequelae of surgery; when it is in direct contact with internal organs and organs, it is easy to cause damage, which ca

Method used

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  • Tissue restoration fiber membrane, production method and application thereof, and tissue restoration product
  • Tissue restoration fiber membrane, production method and application thereof, and tissue restoration product
  • Tissue restoration fiber membrane, production method and application thereof, and tissue restoration product

Examples

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Example Embodiment

[0058] As a preferred preparation method of the fibrous membrane for tissue repair of the present invention, it specifically includes the following steps:

[0059] (1) Dissolve the fiber filament material in a solvent to obtain a fiber filament material solution;

[0060] (2) Load the fiber filament material solution obtained in step (1) into an electrospinning injector, perform electrospinning, and receive the fiber filaments into a film-like structure to obtain a fiber membrane;

[0061] (3) The fiber membrane prepared in step (2) is fixed on four sides, and then vacuum-dried and shaped at 30-60° C., with a vacuum degree of -0.06 to -0.12 MPa, to obtain a fiber membrane for tissue repair.

[0062] In the above step (3), the shaping is carried out at 30-60°C, preferably at 35-55°C.

[0063] And before the shaping in step (3), the fiber membrane is infiltrated with a solvent different from the solvent in step (1), provided that the fiber membrane is not completely swollen. Among them, ...

Example Embodiment

[0075] Example 1

[0076] (1) Dissolve PLLA in hexafluoroisopropanol to prepare a solution of 10.5g / dL.

[0077] (2) Put the solution obtained in step (1) in a syringe connected with a high-pressure needle, adjust the receiving distance of the receiving device to 26cm, adjust the micro-syringe pump to advance the PLLA at a rate of 6ml / h, and then adjust the positive high pressure to 25KV, the negative pressure is 0kv, the rotating roller is used as the receiving device, the rotating speed is 100rpm, and then the electrospinning is carried out for 6h. After the electrostatic spinning is completed, the film material is removed from the roller, and then vacuum dried to remove the solvent to obtain a fiber film.

[0078] (3) Fix the membrane material prepared in step (2) on all four sides, and shape it for 72 hours under the conditions of a temperature of 55°C and a vacuum of -0.1MPa to prepare a fiber membrane for tissue repair. The fibers in the fiber membrane for tissue repair The w...

Example Embodiment

[0080] Example 2

[0081] (1) Dissolve PLLA in hexafluoroisopropanol to prepare a solution of 11.5g / dL.

[0082] (2) Put the solution obtained in step (1) in a syringe connected with a high-pressure needle, adjust the receiving distance of the receiving device to 27cm, adjust the micro-syringe pump to advance the PLLA at 6.3ml / h, and then adjust the positive high pressure It is 24KV, the negative pressure is 0kv, the rotating roller is used as the receiving device, the rotating speed is 100rpm, and then the electrospinning is performed for 7h to obtain the fiber membrane, and then the solvent is removed by vacuum drying.

[0083] (3) Fix the membrane material prepared in step (2) on all sides, infiltrate it with 95% alcohol with a volume concentration of 5 minutes, and shape it for 48 hours at a temperature of 50℃ and a vacuum of -0.098MPa to prepare tissue repair Fibrous membrane, the fibrous filaments in the fibrous membrane for tissue repair have a ring-shaped convex structure. ...

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Abstract

The invention relates to a tissue restoration fiber membrane, a production method and an application thereof, and a tissue restoration product. The tissue restoration fiber membrane is formed by interlacing fiber yarns with the diameter of 10 nm to 100 [mu]m, the fiber membrane has a pore structure formed by interlacing the fiber yarns, every fiber yarn is provided with an annular projection structure in a radial direction, and the bulkiness of the fiber membrane is not less than 2 cm<3>/g and less than 200 cm<3>/g. The invention also discloses the production method of the tissue restoration fiber membrane, the application of the tissue restoration fiber membrane in the production of the tissue restoration product, and the tissue restoration product produced by using the fiber membrane.

Description

technical field [0001] The invention relates to a fibrous membrane for tissue repair, a preparation method and application thereof, and a product for tissue repair. Background technique [0002] In modern surgical operations, it is very common to use tissue repair membranes to repair tissues and organs, such as tissue repair membranes in hernia repair, female pelvic floor dysfunction repair, dura / spinal defect repair, nerve conduit defect repair, blood vessel The repair of ligaments, ligament repair, bone defect repair and other applications. Due to the particularity of human tissue structure and function, an ideal fibrous membrane for tissue repair should have the following properties: ①Good biocompatibility, able to guide tissue growth and achieve ideal repair; ②Facilitate cell adhesion, crawling and growth, to achieve tissue regeneration ; ③ a certain strength, able to resist mechanical stress, and provide sufficient mechanical support before the healthy tissue is fully ...

Claims

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Application Information

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IPC IPC(8): A61L27/16A61L27/18A61L27/20A61L27/22A61L27/24A61L27/26A61L27/60D04H1/4382D04H1/728D06C7/02
CPCA61L27/16A61L27/18A61L27/20A61L27/225A61L27/24A61L27/26A61L27/60A61L2430/00A61L2430/02A61L2430/10A61L2430/20A61L2430/32D04H1/4382D04H1/728D06C7/02
Inventor 邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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