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Synthetic method of bagasse xylan gallate-g-MAA/BA with anti-gastric cancer activity

A technology of gallate and gallic acid, which is applied in the direction of antineoplastic drugs and drug combinations, and can solve the problems of weak pertinence and low anticancer activity

Active Publication Date: 2017-03-15
GUILIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, if gallic acid and bagasse xylan are esterified, the advantages of the two can be combined to enhance the anticancer activity of bagasse xylan esterified derivatives, but monoesterified bagasse xylan derivatives still exist Defects such as low anticancer activity and weak pertinence

Method used

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  • Synthetic method of bagasse xylan gallate-g-MAA/BA with anti-gastric cancer activity
  • Synthetic method of bagasse xylan gallate-g-MAA/BA with anti-gastric cancer activity
  • Synthetic method of bagasse xylan gallate-g-MAA/BA with anti-gastric cancer activity

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Experimental program
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Embodiment

[0052](1) Put the bagasse xylan in a vacuum drying oven at 60° C. and dry it to a constant weight to obtain dry basis bagasse xylan.

[0053] (2) Add 17 g of gallic acid into a 250 mL four-neck flask, add 40 mL of analytically pure acetic anhydride and 1.0 mL of analytically pure pyridine therein, and react at 5-20° C. for 10 hours.

[0054] (3) Pour the material obtained in step (2) into a beaker, and add 8.3 mL of sulfuric acid solution with a mass fraction of 15% to it under stirring with a glass rod until crystals are precipitated.

[0055] (4) Suction filter the material obtained in step (3), pour the suction filtrate into a beaker, and add 45 mL of saturated sodium bicarbonate solution therein under stirring with a glass rod.

[0056] (5) Add 6.5 mL of 20% hydrochloric acid solution to the material system obtained in step (4), and let stand for 5 hours.

[0057] (6) Suction filter the product obtained in step (5), wash the precipitate with 20 mL of distilled water for 3...

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Abstract

The invention discloses a synthetic method of bagasse xylan gallate-g-MAA / BA with anti-gastric cancer activity. According to the synthetic method, bagasse xylan is used as a starting material and gallic acid is used as an esterifying agent to synthesize bagasse xylan gallate; and the bagasse xylan gallate is used as a raw material, ammonium persulfate is used and an initiator, and methacrylic acid and butyl acrylate monomer are mixed grafting monomers, and graft copolymerization is carried out to synthesize the bagasse xylan gallate-g-methacrylic acid / butyl acrylate. The prepared product is obtained by graft copolymerization on the basis of a bagasse xylan esterified derivative. The product has properties of esterified xylan and also has function group activity of the grafting monomers. Thus, the anti-gastric cancer activity is further enhanced.

Description

technical field [0001] The invention relates to a synthesis method of anti-gastric cancer active bagasse xylan gallate-g-methacrylic acid (MAA) / butyl acrylate (BA). Background technique [0002] In recent years, with the improvement of people's awareness of environmental protection and the development of green chemistry, people have begun to conduct more in-depth research on the structure and performance of agricultural and forestry wastes such as wheat straw, sugar cane, corncobs, etc. application field. Among them, xylan extracted from bagasse is a kind of high-molecular carbohydrate based on biomass, which has biological activities such as anti-cancer, anti-HIV, and anti-coagulation. The study found that in order to further improve the anticancer activity of bagasse xylan, chemical modification of bagasse xylan is required. [0003] Gallic acid and its esterified derivatives have anti-tumor, anti-inflammatory, anti-mutation, anti-oxidation, anti-free radical and other e...

Claims

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Application Information

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IPC IPC(8): C08F251/00C08F220/18C08F220/06C08B37/14A61P35/00
CPCC08B37/0057C08F251/00C08F220/1804
Inventor 李和平钱敬侠张淑芬左凯孙彦邹英东黄日娴卢纯燕韦文玉
Owner GUILIN UNIVERSITY OF TECHNOLOGY