Method for in-situ construction of multistage nanometer topological structure on titanium-based implant surface based on salt corrosion

Abstract

The invention discloses a method for in-situ construction of a multistage nanometer topological structure on a titanium-based implant surface based on salt corrosion. The method comprises the following steps: immersing pickled titanium or titanium alloy in a phosphate solution for low temperature heating treatment; performing heat treatment on the treated titanium or titanium alloy, washing with water and then drying to obtain a titanium-based implant with a multistage nanostructure formed on the surface. According to the method, salt solution is adopted as a medium to corrode titanium or titanium alloy, the titanium-based implant with the multistage nanostructure formed on the surface after heat treatment is obtained, conditions in the treatment process are mild, and no residue of strong acid or strong alkali exists; the formed multistage nanostructure has excellent biocompatibility, can promote the adhesion and growth of bone-related cells, and is expected to greatly improve the bone integration ability of the implant; the method can also be used in combination with other surface micrometer methods, can be used for constructing a micro-nanometer hybrid topological structure on the surface of the implant, and is expected to produce novel and efficient orthopedic implants and dental implants.

Description

technical field

[0001] The invention relates to the field of biological materials, in particular to a method for constructing a multi-level nano-topological structure in situ on the surface of a titanium-based implant based on salt erosion. Background technique

[0002] Titanium and its alloy materials are widely used in the fields of orthopedics and dental implants due to their excellent biocompatibility and excellent mechanical properties. However, titanium alloys are biologically inert materials and cannot actively induce new bone around the implant after being implanted in the human body. Growth, resulting in insufficient bonding strength of the interface between the implant and natural bone, increasing the risk of implant loosening.

[0003] Surface modification technology can improve the osseointegration ability of implants by changing the chemical and physical properties of the implant surface while retaining the excellent mechanical properties of titanium alloy mater...

Images