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Method for in-situ construction of multistage nanometer topological structure on titanium-based implant surface based on salt corrosion

A topological structure and implant technology, applied in prosthesis, medical formula, medical science, etc., can solve the problems of limited nanostructure control ability, cumbersome processing process, and high processing cost, and achieve the promotion of selective adsorption, application safety, and corrosion resistance. The effect of mild process conditions

Active Publication Date: 2017-03-15
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the current chemical treatment methods involve strong acid and strong alkali. In order to avoid the harm of residual acid and alkali to cells and tissues, implants prepared by chemical methods need to be rinsed for a long time. The treatment process is cumbersome and the production efficiency is low. Easy to cause hydrogen embrittlement, high processing cost
In addition, such methods are better at controlling micron-level morphology, and have extremely limited ability to control nanostructures.

Method used

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  • Method for in-situ construction of multistage nanometer topological structure on titanium-based implant surface based on salt corrosion
  • Method for in-situ construction of multistage nanometer topological structure on titanium-based implant surface based on salt corrosion
  • Method for in-situ construction of multistage nanometer topological structure on titanium-based implant surface based on salt corrosion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] (1) Measure 20ml of pure water, 6ml of 48% HF and 4ml of 48% HNO 3 , Dilute 5 times after mixing to prepare pickling solution. Take an appropriate amount of pickling solution and put it into a beaker, put the titanium alloy into it and wash it for 30 seconds, then discard the obtained light yellow-green liquid, and ultrasonically clean it three times with ultrapure water.

[0074] (2) Weigh 0.663g of (NH 4 ) 2 HPO 4 Dissolve in 10ml deionized water, dilute 10 times to obtain 0.05mol / L (NH 4 ) 2 HPO 4 Put the solution in a closed beaker, immerse the cleaned titanium alloy in it, seal it, put it in an oven, and keep it warm at 60°C for 4h. The obtained titanium alloy was ultrasonically cleaned with ultrapure water for 10 min.

[0075] (3) Place the sample in a muffle furnace for soaking at 500°C for 1 h, and after natural cooling, use ultrapure water to ultrasonically clean it for 3 min.

[0076] figure 1The surface morphology of the titanium alloy after treatmen...

Embodiment 2

[0078] (1) Measure 20ml of pure water, 6ml of 48% HF and 4ml of 48% HNO 3 , mixed and diluted 10 times to prepare pickling solution. Take an appropriate amount of pickling solution and put it into a beaker, put titanium into it and wash it for 2 minutes, then discard the obtained light yellow-green liquid, and clean it three times with ultrapure water ultrasonically.

[0079] (2) Weigh 2.641g of (NH 4 ) 2 HPO 4 Dissolve in 10ml deionized water to obtain 2mol / L (NH 4 ) 2 HPO 4 Put the solution in a closed beaker, immerse the cleaned titanium in it, seal it, put it in an oven, and keep it warm at 40°C for 24h. The obtained titanium was ultrasonically cleaned with ultrapure water for 10 min.

[0080] (3) The sample was placed in a muffle furnace for soaking at 500°C for 6 hours, and after natural cooling, it was ultrasonically cleaned with ultrapure water for 3 minutes.

[0081] figure 2 It is the topography of titanium surface after treatment in this embodiment. It ca...

Embodiment 3

[0083] (1) Measure 20ml of pure water, 6ml of 48% HF and 4ml of 48% HNO 3 , Diluted 30 times after mixing to prepare pickling solution. Take an appropriate amount of pickling solution and put it into a beaker, put the titanium alloy into it and wash it for 5 minutes, then discard the obtained light yellow-green liquid, and clean it three times with ultrapure water ultrasonically.

[0084] (2) Weigh 5.282g of (NH 4 ) 2 HPO 4 Dissolve in 10ml deionized water to obtain 4mol / L (NH 4 ) 2 HPO 4 Put the solution in a closed beaker, immerse the cleaned titanium alloy in it, seal it, put it in an oven, and keep it warm at 100°C for 0.5h. The obtained titanium alloy was ultrasonically cleaned with ultrapure water for 10 min.

[0085] (3) Place the sample in a muffle furnace for soaking at 500°C for 0.5 h, and after natural cooling, ultrasonically clean it with ultrapure water for 3 min.

[0086] image 3 The titanium alloy surface morphology after the treatment of this embodime...

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Abstract

The invention discloses a method for in-situ construction of a multistage nanometer topological structure on a titanium-based implant surface based on salt corrosion. The method comprises the following steps: immersing pickled titanium or titanium alloy in a phosphate solution for low temperature heating treatment; performing heat treatment on the treated titanium or titanium alloy, washing with water and then drying to obtain a titanium-based implant with a multistage nanostructure formed on the surface. According to the method, salt solution is adopted as a medium to corrode titanium or titanium alloy, the titanium-based implant with the multistage nanostructure formed on the surface after heat treatment is obtained, conditions in the treatment process are mild, and no residue of strong acid or strong alkali exists; the formed multistage nanostructure has excellent biocompatibility, can promote the adhesion and growth of bone-related cells, and is expected to greatly improve the bone integration ability of the implant; the method can also be used in combination with other surface micrometer methods, can be used for constructing a micro-nanometer hybrid topological structure on the surface of the implant, and is expected to produce novel and efficient orthopedic implants and dental implants.

Description

technical field [0001] The invention relates to the field of biological materials, in particular to a method for constructing a multi-level nano-topological structure in situ on the surface of a titanium-based implant based on salt erosion. Background technique [0002] Titanium and its alloy materials are widely used in the fields of orthopedics and dental implants due to their excellent biocompatibility and excellent mechanical properties. However, titanium alloys are biologically inert materials and cannot actively induce new bone around the implant after being implanted in the human body. Growth, resulting in insufficient bonding strength of the interface between the implant and natural bone, increasing the risk of implant loosening. [0003] Surface modification technology can improve the osseointegration ability of implants by changing the chemical and physical properties of the implant surface while retaining the excellent mechanical properties of titanium alloy mater...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23F1/14A61L27/06
CPCA61L27/06A61L2400/18A61L2430/02A61L2430/12C23F1/14
Inventor 王国成宋小霞
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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