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Preparation method of palladium-103 sealed seed source core

A technology of sealing seed source and source core, which is applied in the direction of drug combination, antineoplastic drugs, radioactive carriers, etc., can solve the problems of complex operation and heating, and achieve the effects of reducing radiation dose, improving production efficiency, and stabilizing the reaction system

Active Publication Date: 2017-03-29
天津赛德生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reaction system of this method is relatively stable, the operation is complicated, heating is required, and ammonia gas is released during the reaction.

Method used

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  • Preparation method of palladium-103 sealed seed source core

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A preparation method of palladium-103 sealed seed source core, comprising the following steps:

[0023] Put 100 silver rods (Φ0.3×3mm) into a 15mL reaction flask, add 0.2mL 0.1mol / L sodium citrate aqueous solution, 0.3mL 0.02mol / L palladium chloride aqueous solution and 0.5mL 0.04mol / L hydroxide Sodium aqueous solution, mix, react for 2min, then add 1mL 100mCi / mL radioactive palladium chloride-103 aqueous solution and 0.1mL 1.0mol / L sodium thiosulfate aqueous solution, adjust pH = 10, shake for 30 minutes, discard the supernatant, use After washing with ion water for 3 times and drying in the air, the palladium-103 sealed seed source core can be obtained. Then put the prepared source core into a Φ0.5mm titanium tube and seal it with a laser welding machine, see figure 1 .

[0024] The activity of the palladium-103 in the solution after the reaction is 0.4mCi, the utilization rate of the palladium-103 is 99.6%, and the average activity of the palladium-103 source core ...

Embodiment 2

[0027] A preparation method of palladium-103 sealed seed source core, comprising the following steps:

[0028] Put 100 silver rods (Φ0.5×3mm) into a 15mL reaction flask, add 0.01mL 2mol / L sodium citrate aqueous solution, 0.1mL 0.06mol / L palladium chloride aqueous solution and 0.01mL 2mol / L sodium hydroxide aqueous solution , mix, react for 1min, then add 0.1mL 1000mCi / mL radioactive palladium chloride-103 aqueous solution and 0.1mL 1.0mol / L sodium thiosulfate aqueous solution, adjust pH=6, shake for 60 minutes, discard the supernatant, wash with acetone Twice, dry it to get the palladium-103 sealed seed source source core. Then put the prepared source core into a Φ0.8mm titanium tube and seal it with a laser welding machine.

[0029] The activity of the palladium-103 in the solution after the reaction is 0.75mCi, the utilization rate of the palladium-103 is 99.25%, and the average activity of the palladium-103 source core is 0.65mCi.

Embodiment 3

[0031] A preparation method of palladium-103 sealed seed source core, comprising the following steps:

[0032] Put 100 silver rods (Φ0.7×2mm) into a 15mL square quartz bottle, add 2mL 0.01mol / L potassium citrate aqueous solution, 2mL 0.003mol / L palladium chloride aqueous solution and 1mL 0.02mol / L sodium hydroxide aqueous solution , mixed, reacted for 5 minutes, then added 1mL 180mCi / mL radioactive palladium chloride-103 aqueous solution and 2mL 0.05mol / L potassium thiosulfate aqueous solution, adjusted pH = 11, oscillated for 40 minutes, discarded the supernatant, washed twice with ethanol , and dried to obtain palladium-103 sealed seed source source core. Then put the prepared source core into a Φ1.0mm titanium tube and seal it with a laser welding machine.

[0033] The activity of the palladium-103 in the solution after the reaction is 0.70mCi, the utilization rate of the palladium-103 is 99.61%, and the average activity of the palladium-103 source core is 1.05mCi.

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Abstract

The invention discloses a preparation method of a palladium-103 sealed seed source core. The preparation method comprises the steps of putting 100 silver bars and adding a citrate aqueous solution, a soluble palladium salt aqueous solution and a sodium hydroxide aqueous solution in a reaction vessel according to the proportion; mixing the materials to enable the materials to react; then, adding a radioactive palladium chloride-103 aqueous solution and a thiosulfate aqueous solution; carrying out oscillatory reaction under the condition that the pH is 6 to 11; discarding the supernatant; and washing the remaining material with acetone, deionized water or ethyl alcohol, so as to obtain the palladium-103 sealed seed source core. According to the preparation method, the reaction system is stable, the prepared palladium-103 sealed seed source core is uniform in dose and is firm and compact, the utilization rate of palladium-103 is high, the reaction time is short, the entire preparation process needs 60 min at most, the operation is achieved through one step at the room temperature, the operation procedure is simple and easy to control, the production efficiency is improved, the labor intensity is reduced, the radiation dose is decreased, utilized chemical reagents are conventional and commercially available, nontoxic and low in price, and the production cost is low.

Description

technical field [0001] The invention belongs to the technical field of medical preparations containing radioactive substances, and in particular relates to a preparation method of a palladium-103 sealed seed source core. Background technique [0002] Interstitial implantation of radioactive seeds to treat tumors is to implant radioactive particles (radioactive sealed seed source) into the tumor or around the tumor through intraoperative or percutaneous puncture with an implanter, and kill them with low-energy γ-rays or X-rays emitted by radionuclides. Tumor cells to achieve the purpose of treating and alleviating diseases. This technology is suitable for the implantation treatment of various solid tumors, such as prostate cancer, breast cancer, liver cancer, head and neck tumors, pancreatic cancer and ovarian cancer, etc., and has achieved the same therapeutic effect as surgery and external radiation therapy, with side effects Small, low recurrence rate and minimal trauma. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K51/02A61P35/00
Inventor 阎尔坤白红升张兴福朱辉李佳崔贝
Owner 天津赛德生物制药有限公司
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