Method for synthesizing calcimimetic cinacalcet hydrochloride
A technology for the synthesis of cinacalcet hydrochloride and calcimimetic agent, which is applied in the field of synthesizing calcimimetic agent cinacalcet hydrochloride, can solve the problems of secondary substitution by-products with many unknown impurities and low reaction yield, and achieve cheap raw materials and easy operation Simple, high-yield results
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[0037] The following description serves to disclose the present invention to enable those skilled in the art to carry out the present invention. The preferred embodiments described below are only examples, and those skilled in the art can devise other obvious variations.
[0038] The method is a new synthetic route: use trityl chloride to protect the amino protection of (R)-1-(1-naphthyl)ethylamine, and then carry out the scheme of nucleophilic substitution reaction. The specific synthetic route is as follows :
[0039]
[0040] Step 1: Preparation of methylsulfonyl-3-(3-trifluoromethylphenyl)propyl ester B
[0041] At room temperature, add 15ml CH to a 100ml reaction vial 2 Cl 2 , 3g 3-(3-trifluoromethylphenyl) propanol A, 2.2g triethylamine, stir and dissolve, add 2g methanesulfonyl chloride dropwise, after the dropwise addition, keep the temperature for 2-3 hours, and add to the reaction kettle Add 9ml of 1mol / l dilute hydrochloric acid, stir and separate the liquids...
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