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Vitamin C microcapsule and preparation method thereof

A technology of vitamins and microcapsules, which is applied in the directions of pharmaceutical formulations, cosmetic preparations, dressing preparations, etc., can solve the problems of reducing the efficacy of vitamin C, and achieve the effects of promoting absorption and penetration, good biocompatibility, and simple preparation process

Inactive Publication Date: 2017-04-26
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the above-mentioned technical problems in the prior art, the present invention provides a vitamin C microcapsule and a preparation method thereof. The vitamin C microcapsule and the preparation method thereof shall solve the problem that the vitamin C capsule in the prior art is susceptible to light The technical problem of reducing the efficacy of vitamin C due to the destruction of factors such as heat, oxygen, etc.

Method used

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  • Vitamin C microcapsule and preparation method thereof
  • Vitamin C microcapsule and preparation method thereof
  • Vitamin C microcapsule and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0047] Based on 1000g of formula raw materials, take 1g of vitamin C, 10g of lipophilic emulsifier, 10g of chitosan, 10g of glacial acetic acid, 10g of water, 0.05g of glutaraldehyde, and 958.95g of liquid oil.

[0048] Described lipophilic emulsifier is ceteareth-6;

[0049] The liquid oil is caprylic capric triglyceride;

[0050] The steps of preparation method are as follows:

[0051] 1) glacial acetic acid is dissolved in water to make acetic acid solution;

[0052] 2) Chitosan is added to the acetic acid solution prepared in step 1), heated at 30° C. to dissolve completely, and the chitosan acetic acid solution is obtained after standing to remove air bubbles;

[0053] 3) Add vitamin C to the solution prepared in step 2), and stir evenly at 25°C to obtain the first solution;

[0054]4) Add the lipophilic emulsifier into the liquid oil, and stir evenly in a constant temperature water bath at 25°C to obtain the second solution;

[0055] 5) Heating the second solution at...

Embodiment 1

[0059] Embodiment 1 comparative example:

[0060] That is to configure 1% vitamin C aqueous solution.

[0061] The vitamin C microcapsules obtained in the above-mentioned embodiment 1 and the comparative example of embodiment 1 obtained contain 1% vitamin C aqueous solution permeability data measurement, the results are shown in the following table:

[0062]

Embodiment 2

[0064] Based on 1000g of formula raw materials, take 50g of vitamin C, 300g of lipophilic emulsifier, 100g of chitosan, 100g of glacial acetic acid, 300g of water, 1g of glutaraldehyde, and 149g of liquid oil.

[0065] Described lipophilic emulsifier is ceteareth-25;

[0066] Described liquid grease is isopropyl myristate;

[0067] The steps of preparation method are as follows:

[0068] 1) glacial acetic acid is dissolved in water to make acetic acid solution;

[0069] 2) Chitosan is added to the acetic acid solution prepared in step 1), heated at 60° C. to completely dissolve, and the chitosan acetic acid solution is obtained after standing to remove air bubbles;

[0070] 3) Add vitamin C to the solution prepared in step 2), and stir at 50°C to obtain the first solution;

[0071] 4) Add the lipophilic emulsifier into the liquid oil, and stir evenly in a constant temperature water bath at 60°C to obtain the second solution;

[0072] 5) Heating the second solution at a con...

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Abstract

A vitamin C microcapsule is prepared from components in percentage concentration by mass as follows: 0.1%-5% of vitamin C, 1%-30% of a lipophilic emulsifier, 1%-10% of chitosan, 1%-10% of glacial acetic acid, 1%-30% of water, 0.005%-0.1% of glutaraldehyde and the balance of liquid fat. The invention further provides a preparation method of the microcapsule. The preparation method comprises steps as follows: the vitamin C, chitosan and glacial acetic acid are heated and dissolved in water, and an aqueous phase component is prepared; the lipophilic emulsifier and liquid fat are mixed, heated anddispersed uniformly, and an oil phase component is prepared; the aqueous phase component is added to the oil phase component during stirring, and emulsion is prepared; glutaraldehyde is added to theemulsion and cured, a mixture is sequentially centrifuged, washed with ethanol and petroleum ether dispersed with acetone and air-dried, and the vitamin C microcapsule is obtained. The vitamin C microcapsule has high degree of sphericity and good biocompatibility, safety and slow-release effect and effectively prevents the vitamin C from oxidative deterioration under the influence of external environment.

Description

technical field [0001] The invention belongs to the field of cosmetics and relates to a microcapsule, in particular to a vitamin C microcapsule and a preparation method thereof. Background technique [0002] Vitamin C, also known as L-ascorbic acid, is a natural antioxidant that blocks the production of melanin by inhibiting the activity of tyrosinase in the skin to achieve whitening effect. Although the activity of vitamin C is high, it is unstable. It is easily damaged by light, heat, oxygen and other factors and loses its reducing ability, which limits its effective use in cosmetics. [0003] Chitosan is the only alkaline polysaccharide among natural polysaccharides, which has unique physical and chemical properties and biological functions. Chitosan and its decomposition products are non-toxic, have excellent properties such as biocompatibility, biodegradability, safety and good moldability, and have certain antibacterial and anti-inflammatory effects, and promote wound...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/67A61K8/11A61K8/86A61K8/73A61K8/37A61K8/36A61K8/33A61Q19/02A61Q19/00
CPCA61K8/11A61K8/33A61K8/36A61K8/37A61K8/375A61K8/676A61K8/736A61K8/86A61K2800/10A61Q19/00A61Q19/02
Inventor 张婉萍赵晓伟宋丽莉朱海洋
Owner SHANGHAI INST OF TECH
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