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Preparation method of meso-porous silica nanoparticles

A technology of mesoporous silica and nanoparticles, applied in the field of biomedicine, to achieve good biocompatibility and biodegradability, simple synthesis process, and mild reaction conditions

Inactive Publication Date: 2017-04-26
HUBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many methods for synthesizing mesoporous silica nanoparticles, particle size design is an important parameter for cell tracking and nano-drug carrier particle systems. The particle size of nanoparticles can affect the mechanism of cellular uptake and the passage of nanoparticles through tissues. However, how to obtain nanoparticles with controllable size and shape and excellent drug loading and sustained release performance is still a formidable challenge

Method used

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  • Preparation method of meso-porous silica nanoparticles
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  • Preparation method of meso-porous silica nanoparticles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Pour 16mL of distilled water and 2.35mL of ethanol into a 100mL sealed round bottom flask with a stopper, then add 0.56g of cetyltrimethylammonium chloride (CTAC), and stir magnetically at room temperature for 10min to make the solution fully mix;

[0032] (2) Then add 2.6mL triethanolamine to the mixed solution prepared in step (1), and continue to stir for 15min until the triethanolamine is completely dissolved;

[0033] (3) Heat the above solution to 60°C, then add 1.454mL orthosilicate ethyl ester within 2-3min, and continue to stir for 2h;

[0034] (4) After the reaction solution is cooled to room temperature, the product obtained is centrifuged, and the obtained solid is washed several times with distilled water and ethanol;

[0035] (5) Removal of the template: the solid obtained in step (4) was placed in a mixed solution consisting of 45 mL of ethanol and 5 mL of hydrochloric acid (37%, volume fraction), and refluxed twice at 60° C. for 2 hours each time. ...

Embodiment 2

[0039] The preparation method for preparing mesoporous silica nanoparticles is the same as in Example 1, except that the amount of TEA added is 0.87 mL, and the molar ratio of TEOS / TEA is controlled to be 1:1.

[0040] The same method as in Example 1 was used to test the particle size of the mesoporous silica nanoparticles prepared in this example. Tested by the particle size analyzer, the average particle size of the obtained mesoporous silica nanoparticles is 200.6nm, the particle size is normally distributed, and the particle size dispersion index is 0.199. The particle size of the mesoporous silica nanoparticles synthesized under this condition is It is a bit too large, which may be caused by the agglomeration of nanoparticles.

Embodiment 3

[0042] The preparation method for preparing mesoporous silica nanoparticles is the same as that of Example 1, except that the amount of TEA added is 1.74 mL, and the molar ratio of TEOS / TEA is controlled to be 1:2.

[0043] The same method as in Example 1 was used to test the particle size of the mesoporous silica nanoparticles prepared in this example. As tested by a particle size analyzer, the average particle size of the obtained mesoporous silica nanoparticles was 150.8nm, the particle size was normally distributed, and the particle size dispersion index was 0.108.

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Abstract

The invention discloses a preparation method of meso-porous silica nanoparticles. The method comprises the following steps: mixing ethanol with distilled water according to a certain ratio in order to obtain a solvent, adding triethanolamine used an alkali and a chelating agent, adding cetyltrimethylammonium chloride used as a template, heating the above obtained solution to 25-80 DEG C, adding ethyl orthosilicate within 2-3 min, stirring and reacting the above substances for 0.5-6 h, carrying out solid-liquid separation on a product obtained after the above reaction solution cools to room temperature, washing obtained solid with water and ethanol, removing the template, respectively washing the above obtained material with distilled and anhydrous ethanol multiple times, and dispersing obtained meso-porous silica nanoparticles in 25 mL of water to form a colloid. The colloid has high stability, is degradable and can be applied to the field of biomedicines. The preparation method has the advantages of simple process, easiness in operation, good repeatability and cheap and easily available raw materials, and the prepared meso-porous silica nanoparticles has the advantages of monodispersion, controllable morphology and large specific surface area.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a preparation method of mesoporous silica nanoparticles. Background technique [0002] Drug controlled and sustained-release carrier materials have received extensive attention due to their characteristics of small dosage, long action time, and good targeting effect. At present, with the development of compound drug carrier materials and transdermal drug delivery devices, controlled and sustained-release materials are widely used in clinical practice. The application in treatment will certainly be more extensive. [0003] Since Kerse first synthesized MCM-41 mesoporous molecular sieves in 1992, mesoporous materials have been widely used in chemical industry, biotechnology, adsorption separation, catalysis and other fields. Mesoporous materials have the advantages of regular mesoporous channels and uniform and adjustable pore size, large specific surface area and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B33/12B82Y40/00
CPCC01B33/12C01P2004/04C01P2004/52C01P2004/62C01P2006/12C01P2006/16
Inventor 刘明星王晚霞
Owner HUBEI UNIV OF TECH
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