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Bionic bone repair material having good machinery performance and biological activity and preparation method thereof

A technology of bioactivity and mechanical properties, applied in medical science, prosthesis, coating, etc., can solve the problems of limited bioactivity improvement of PCL stents, uneven distribution of β-TCP, complex mixing process, etc., to improve biological Effects of activity, complete void connectivity, and increased contact area

Pending Publication Date: 2017-05-10
GUANGDONG REGEN-MED SCI & TECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the composite scaffold material prepared by this method has the following problems: (1) The mixing process is complicated, and the nano-scale inorganic β-TCP particles are prone to agglomeration during the mixing process with the organic macromolecule PCL, resulting in dispersion (2) In the β-TCP-PCL composite scaffold formed by FDM, most of the inorganic β-TCP particles are wrapped by organic PCL, and β-TCP cannot be evenly distributed in the scaffold material, which affects the biological activity of the PCL scaffold. limited improvement

Method used

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  • Bionic bone repair material having good machinery performance and biological activity and preparation method thereof
  • Bionic bone repair material having good machinery performance and biological activity and preparation method thereof
  • Bionic bone repair material having good machinery performance and biological activity and preparation method thereof

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Embodiment 1

[0049] This embodiment provides a method for preparing a bionic bone repair material with good mechanical properties and biological activity, including the following specific steps:

[0050] Step (1): Use rapid prototyping technology to 3D print large-aperture PCL scaffolds to obtain a primary structure, such as figure 1 ,

[0051] Establish a CAD model of a three-dimensional PCL bracket with a pore size of 100 μm through computer-aided design software, convert the CAD model into an STL. Printing, when the three-dimensional stent is printed, the direction of the nozzle shape is stacked layer by layer according to (0°, 60°, 120°);

[0052] The specific steps of 3D scaffold printing include:

[0053] A. Put the PCL granule raw material into the melter of the rapid prototyping machine and heat it to 50°C to make the PCL material flow;

[0054] B. If figure 2 As shown, according to the CAD graphics in STL. format, under the control of the calculation, the flowing PCL material...

Embodiment 2

[0073] This embodiment provides a method for preparing a bionic bone repair material with good mechanical properties and biological activity, including the following specific steps:

[0074] Step (1): Use rapid prototyping technology to 3D print large-aperture PCL scaffolds to obtain a primary structure, such as figure 1 ,

[0075] The CAD model of the three-dimensional PCL bracket with a pore size of 1500 μm is established by computer-aided design software, and the CAD model is converted into an STL. format file, which is then input into the data processing software of the fusion molding machine after layering processing, and the three-dimensional bracket is made by using the 3DP molding system Printing, when the three-dimensional stent is printed, the direction of the nozzle shape is stacked layer by layer according to (0°, 90°);

[0076] The specific steps of 3D scaffold printing include:

[0077] A. Put the PCL granule raw material into the melter of the rapid prototypin...

Embodiment 3

[0097] This embodiment provides a method for preparing a bionic bone repair material with good mechanical properties and biological activity, including the following specific steps:

[0098] Step (1): Use rapid prototyping technology to 3D print large-aperture PCL scaffolds to obtain a primary structure, such as figure 1 ,

[0099] Establish a CAD model of a three-dimensional PCL bracket with a pore size of 1000 μm through computer-aided design software, convert the CAD model into an STL. Printing, when the three-dimensional stent is printed, the direction of the nozzle shape is stacked layer by layer according to (0°, 60°, 120°);

[0100] The specific steps of 3D scaffold printing include:

[0101] A. Put the PCL particle raw material into the melter of the rapid prototyping machine and heat it to 120°C to make the PCL material flow;

[0102] B. If figure 2 As shown, according to the CAD graphics in STL. format, under the control of the calculation, the flowing PCL mater...

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Abstract

The invention discloses a bionic bone repair material having good machinery performance and biological activity and a preparation method thereof. The preparation method comprises the following steps: 1) using a rapid moulding technology for performing three-dimensional printing on a large aperture PCL rack to obtain a primary structure; 2) activating the surface of the PCL rack having the primary structure; 3) employing collagen network for performing three-dimensional function activation on the PCL rack having the primary structure to obtain a Col-PCL rack having a secondary structure; and 4) employing nano hydroxyapatite particles for bionic mineralization on the Col-PCL rack to obtain an AP-Col-PCL rack having a third structure; The product combines a rapid moulding technology and a biomaterial three-dimensional modification technology, constructs the bionic bone repair material AP-Col-PCL having good machinery performance and biological activity which, and can be used for bone defect research and clinical treatment.

Description

technical field [0001] The invention belongs to the technical field of bionic composite materials, and relates to a bionic bone repair material with good mechanical properties and biological activity and a preparation method thereof. Background technique [0002] Bone is one of the most vulnerable tissues in the human body. The current treatment methods for large segmental bone defects include: autologous bone transplantation, allogeneic and xenogeneic bone transplantation, bone defect repair materials based on biomaterials, etc. Autologous bone transplantation, as the current gold standard for the treatment of bone defects, has been widely used clinically since the beginning of the 19th century. However, autologous bone transplantation has complications such as secondary surgical trauma at the donor site, insufficient bone mass, and pain. Allograft bone and xenograft bone graft, as a common alternative to autologous bone graft, have disadvantages such as potential immune r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/54A61L27/50A61L27/24A61L27/18A61L27/32
Inventor 张智勇王进兵
Owner GUANGDONG REGEN-MED SCI & TECH LTD
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