Compound for preparing near-infrared rate light-emitting upconversion nanomaterial as well as preparation method and application of compound

A technology of nanomaterials and compounds, applied in the field of analytical chemistry, can solve problems such as application limitations, and achieve good light and thermal stability, good anti-interference, and good reversibility

Inactive Publication Date: 2017-05-17
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the lack of reports on the preparation of upconversion nanomaterials with uniform size, small particle size, good water solubility and biocompatibility, their application in bioimaging has been limited.

Method used

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  • Compound for preparing near-infrared rate light-emitting upconversion nanomaterial as well as preparation method and application of compound
  • Compound for preparing near-infrared rate light-emitting upconversion nanomaterial as well as preparation method and application of compound
  • Compound for preparing near-infrared rate light-emitting upconversion nanomaterial as well as preparation method and application of compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Compound 1 adopts the following synthetic route:

[0043]

[0044] Weigh 4-carboxyphenylhydrazine hydrochloride (500mg, 2.46mmol) and sodium hydroxide (98.5mg, 2.46mmol) in a 100mL eggplant-shaped bottle, add an appropriate amount of ethanol for ultrasonication, stir at room temperature, dissolve for 30min, and then Spin out the ethanol, transfer the remaining solid to a 100mL three-neck flask, add 16mL of glacial acetic acid to dissolve, then add sodium acetate (405mg, 4.94mmol), ultrasonically dissolve, and finally add 3-methyl-2-butanone (397μL, 3.7mmol), heated to 100°C, and refluxed for 16h. After the reaction is complete, stop the reaction, cool to room temperature, distill under reduced pressure, spin out glacial acetic acid, cool to 0°C with ice water, slowly add saturated sodium carbonate solution until no bubbles are generated, adjust pH=4 with hydrochloric acid , extracted three times with dichloromethane, the oil phase was collected, dried with anhydrous...

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Abstract

The invention provides a compound for preparing a near-infrared rate light-emitting upconversion nanomaterial as well as a preparation method and an application of the compound. The light emission of the upconversion nanomaterial presents rate change in a pH range of 6.8-8.8, and the upconversion nanomaterial has pH-sensing reversibility, very good light stability, thermal stability and interference resistance and is suitable for bioluminescence imaging in a pH near-infrared rate.

Description

technical field [0001] The invention belongs to the technical field of analytical chemistry, and specifically relates to a compound, a preparation method and its application in the preparation of near-infrared ratiometric luminescent upconversion nanomaterials. Background technique [0002] As an important indicator of biological and physiological processes, pH changes and distribution are related to many life activities of cells such as enzyme activity, cell growth and apoptosis, ion migration and balance, calcium regulation, endocytosis, etc., and when intracellular tumors After the cells are generated, the intracellular pH distribution also changes. For example, the acidic environment may be related to tumor cells or some inflammations. [0003] Fluorescence imaging has become an important tool for studying biomolecules, pathways, and processes in biological cells due to its non-destructive, high sensitivity, fast response, and high signal-to-noise ratio. The reported fl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D209/12C09K11/02C09K11/06C09K11/85G01N21/64
CPCC07D209/12C09K11/02C09K11/06C09K11/7773C09K2211/1029G01N21/6486
Inventor 李占先班亚楠于明明李海霞刘春霞魏柳荷
Owner ZHENGZHOU UNIV
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