Preparation method of bis[2-N-oxide-pyridyl-2-sulfenyl]ethyl]amino
A technology based on oxides and pyridyl, which is applied in the field of preparation of di[2-ethyl]amine, can solve the problems of difficult recovery, large loss, and easy pollution, so as to increase electrophilicity and improve product yield. rate, strong nucleophilicity, and reactivity
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Embodiment 1
[0031] In a 250ml four-necked reaction flask, add 50ml of anhydrous methanol and 0.055mol of sodium methoxide to obtain a sodium alkoxide solution, add 0.05mol of newly prepared bis(2-mercaptoethyl)amine, react for 20 minutes, and add newly prepared 2-chloropyridine-N-oxide 0.15mol. Heating to reflux, TLC tracking the whole process of the reaction, and timely qualitative and quantitative determination of the product and the end of the reaction, to stop the reaction. After cooling, filter, and heat under reduced pressure on a rotary evaporator to evaporate the low boiling point solvent. Add an aqueous solution containing hydrochloric acid to the high boiling residue and stir evenly, adjust the pH to 3, extract three times with ethyl acetate, dry the organic phase with anhydrous sodium sulfate, remove the solvent under reduced pressure on a rotary evaporator to obtain a light yellow liquid crude product, The crude product was purified by column chromatography, and the solvent w...
Embodiment 2
[0035] In a 250ml four-necked reaction flask, add 40ml of anhydrous methanol and 0.045mol potassium ethylate to obtain a potassium alcoholate solution. After adding newly prepared bis(2-mercaptoethyl)amine (0.03mol) to react for 15 minutes, add 0.112 mol of 2-chloropyridine-N-oxide, other preparation processes are the same as in Example 1, and the resulting product yield is 80%.
Embodiment 3
[0037]In a 250ml four-necked reaction flask, add 60ml of anhydrous methanol and 0.065mol of potassium ethoxide to obtain a potassium alkoxide solution, add newly prepared bis(2-mercaptoethyl)amine (0.08mol) and react for 25 minutes, then add 0.175mol of 2-chloropyridine-N-oxide compound, other preparation processes are the same as in Example 1, and the resulting product yield is 81%.
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