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Molecularly imprinted polymeric microspheres as well as preparation method and application thereof

A technology of molecular imprinting and polymers, which is applied in the preparation of microspheres, microcapsule preparations, alkali metal compounds, etc., can solve the problems of low adsorption efficiency and complex preparation methods of molecularly imprinted polymer microspheres, and achieve multiple adsorption sites, With selectivity and enrichment ability, the effect of strong selectivity

Active Publication Date: 2017-05-17
SHANGHAI TOBACCO GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the shortcomings of the prior art described above, the purpose of the present invention is to provide a molecularly imprinted polymer microsphere and its preparation method and application, which are used to solve the problem of complex preparation methods of molecularly imprinted polymer microspheres in the prior art and the low adsorption efficiency. low problem

Method used

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  • Molecularly imprinted polymeric microspheres as well as preparation method and application thereof
  • Molecularly imprinted polymeric microspheres as well as preparation method and application thereof
  • Molecularly imprinted polymeric microspheres as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0049] 3 mmol of NAM and 18 mmol of MAA were weighed and dissolved in a mixed solution of 33 g of toluene and 87 g of acetonitrile, sonicated for 1 h, and allowed to stand for 12 h, so that the template molecule and the functional monomer were fully interacted. Then, 60 mmol of DVB and 0.25 g of AIBN were added, sonicated for 15 min, and nitrogen was passed through for 30 min to remove oxygen. The product obtained after polymerization was put into the eluent of acetic acid / methanol (v / v=1 / 9), and the ultrasonic machine was heated to 60°C, and the template molecule NAM was eluted by ultrasonic. After multiple ultrasonic centrifugation processes, the supernatant of the eluate was detected with a UV-visible spectrophotometer until the UV absorption peak of NAM in the upper eluate disappeared, the template molecules in the MIPs were considered to have been eluted, and then methanol was used. The MIPs were washed three times, the acetic acid was removed, and dried in a vacuum oven ...

Embodiment 2

[0053] 3 mmol of NAM and 21 mmol of MAA were weighed and dissolved in a mixed solution of 48 g of toluene and 98 g of acetonitrile, sonicated for 15 min, and allowed to stand for 14 h to make the template molecule and functional monomer fully interact. Then, 90 mmol of DVB and 0.41 g of AIBN were added, ultrasonicated for 20 min, and nitrogen gas was passed through for 60 min to remove oxygen. The product obtained after polymerization was put into the eluent of acetic acid / methanol (v / v=1 / 10), and the ultrasonic machine was heated to 50°C, and the template molecule NAM was eluted by ultrasonic. After multiple ultrasonic centrifugation processes, the supernatant of the eluate was detected with a UV-visible spectrophotometer until the UV absorption peak of NAM in the upper eluate disappeared, the template molecules in the MIPs were considered to have been eluted, and then methanol was used. The MIPs were washed three times, the acetic acid was removed, and dried in a vacuum oven...

Embodiment 3

[0059] 3 mmol of NAM and 15 mmol of MAA were weighed and dissolved in a mixed solution of 23 g of toluene and 81.7 g of acetonitrile, ultrasonicated for 30 min, and allowed to stand for 12 h, so that the template molecule and the functional monomer were fully interacted. Then, 45 mmol of DVB and 0.16 g of AIBN were added, sonicated for 20 min, and nitrogen was purged for 20 min to remove oxygen. The product obtained after polymerization was put into the eluent of acetic acid / methanol (v / v=1 / 8), and the ultrasonic machine was heated to 40°C, and the template molecule NAM was eluted by ultrasonic. After multiple ultrasonic centrifugation processes, the supernatant of the eluate was detected with a UV-visible spectrophotometer until the UV absorption peak of NAM in the upper eluate disappeared, the template molecules in the MIPs were considered to have been eluted, and then methanol was used. The MIPs were washed three times, the acetic acid was removed, and dried in a vacuum ove...

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Abstract

The invention provides molecularly imprinted polymeric microspheres as well as a preparation method and application thereof. The preparation method specifically comprises the following steps: (1) weighing niacinamide and methacrylic acid and dissolving into a solvent; and carrying out ultrasonic treatment and standing to obtain a mixed solution; (2) adding divinylbenzene and 2,2'-azobis(2-methylpropionitrile) into the mixed solution in the step (1), and carrying out ultrasonic treatment; and after introducing nitrogen gas, sealing and stirring to obtain a polymer; and (3) putting the polymer into an eluting solution, centrifuging after carrying out ultrasonic oscillation, and washing and drying to obtain the product. The preparation method provided by the invention is simple and convenient and the prepared molecularly imprinted polymeric microspheres have high adsorption rate.

Description

technical field [0001] The present invention relates to a molecularly imprinted polymer microsphere and its preparation method and application. Background technique [0002] With the continuous improvement of people's living standards and quality of life, consumers are becoming more and more aware of smoking safety and environmental protection. The incomplete combustion of tobacco in cigarette products results in a certain amount of harmful substances in the smoke, which poses a risk to the health of smokers. Among them, tobacco-specific N-nitrosamines (TSNAs) are a special class of carcinogenic harmful substances contained in tobacco products, and are common components in tobacco leaves, especially air-cured tobacco leaves and cigarette smoke. TSNAs mainly contain 4 kinds, N-nitrosonornicotine (NNN), N-nitrosoneonicotine (NAT), N-nitrosoanabasine (NAB) and 4-methylnitrosamino -1-(3-Pyridyl)-1-butanone (NNK). [0003] Molecularly imprinted polymers (MIPs) are polymers tha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F212/36C08F220/06C08J9/26B01J20/26B01J20/28B01J13/14B01J13/04
CPCB01J13/04B01J13/14B01J20/261B01J20/28021B01J2220/445B01J2220/4812C08F212/36C08J9/26C08J2201/0424C08J2325/02C08F220/06
Inventor 郑晓曼徐同广张晨白若石周骏
Owner SHANGHAI TOBACCO GRP CO LTD
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