Synthesis method of (3,4-dimethoxyphenyl)(4-p henyl fluoride) ketone

Abstract

The invention relates to a synthesis method of (3,4-dimethoxyphenyl)(4-p henyl fluoride) ketone, and solves the problem that in the prior art, the synthesis method brings large amout of pollution and the cost is high. According to the method, acidic ionic liquid is applied as the catalyst which is polymerized by an ionic liquid precursor containing positive electricity and metal halides with negative electricity, wherein, the ionic liquid precursor is [Bmim] C1 or [Bmim] Br, the metal halide is AlCl3, FeC13, ZnCl2 or CuCl2. The synthesis method of (3,4-dimethoxyphenyl)(4-p henyl fluoride) ketone has the advantages of largely reducing the use amout of catalysts, lowering the emission of the waste water, saving the neutralization process of sulfuric acid, eliminating the waste water generated in the step, avoiding the corrosion caused by strong acid. Compared with the original reaction, the emission of slag is omitted. The reaction product is easy to be separated. The post-treatment is simpler. The reaction temperature is low. The energy cost is low. The product yield rate can reach as high as 97% or higher.

Description

technical field [0001] The invention is a new method for synthesizing (3,4-dimethoxyphenyl)(4'-fluorophenyl)methanone with an acidic ionic liquid catalyst. Background technique [0002] (3,4-dimethoxyphenyl)(4'-fluorophenyl)methanone, molecular formula C 15 h 13 FO 3 , molecular weight 260, white or off-white powder. [0003] (3,4-dimethoxyphenyl)(4′-fluorophenyl)methanone can be dissolved in organic solvents and monomers such as ethanol, ether, chloroform, etc., but insoluble in water. It is an important chemical intermediate . It can be used as an ultraviolet absorber, initiator, anhydrous indicator, etc., and is currently mainly used in the preparation of the insecticide flumorph. [0004] Flumorph (common name: Flumorph, trade name: Meike) is a fluorine-containing diphenylacryloylmorpholine fungicide created and developed by Shenyang Research Institute of Chemical Industry. It is the first one with independent intellectual property rights in my country. Agricultural...

AI Technical Summary

Problems solved by technology

[0009] Although anhydrous aluminum chloride can make the reaction obtain ideal yields and is cheap, the disadvantage of this type of catalyst is that the lone pair of electrons in the aromatic ketone product formed by the reaction will complex with the halide catalyst, so it is necessary to add an excessive amount of The ratio of halide catalysts often requires more than 2 mol of Lewis acid catalysts to produce 1 mol of aromatic ketone products, which leads to serious waste of resources in practical applications

At the same time, the complexes generated need to be neutralized by strong acid and strong base, so a large amount of waste liquid is produced, which also leads to environmental unfriendly problems such as equipment damage

In addition to the huge amount of catalyst used, the excessive use of phthalate leads to the discharge of a large amount of waste water and waste residue, and cannot be recycled, resulting in high production costs and high pressure on environmental protection.

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