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Nicotinamide microcapsule and preparation method thereof

A technology of nicotinamide and microcapsules, which is applied in the field of cosmetics, can solve the problems of poor effect of slow-release nicotinamide, and achieve the effects of protecting structural integrity and stability, good sphericity, and simple preparation process

Inactive Publication Date: 2017-06-13
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the above-mentioned technical problems in the prior art, the present invention provides a nicotinamide microcapsule and its preparation method. The nicotinamide microcapsule and its preparation method should solve the problems of the capsule slow-release nicotinamide in the prior art. Technical issues with underperforming

Method used

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  • Nicotinamide microcapsule and preparation method thereof
  • Nicotinamide microcapsule and preparation method thereof
  • Nicotinamide microcapsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Based on 1000g of formula raw materials, take 1g of nicotinamide, 10g of lipophilic emulsifier, 10g of chitosan, 10g of glacial acetic acid, 10g of water, 0.05g of glutaraldehyde, and 958.95g of liquid oil.

[0046] Described lipophilic emulsifier is ceteareth-6;

[0047] The liquid oil is caprylic capric triglyceride;

[0048] The steps of preparation method are as follows:

[0049] 1) glacial acetic acid is dissolved in water to make acetic acid solution;

[0050] 2) Chitosan is added to the acetic acid solution prepared in step 1), heated at 30° C. to dissolve completely, and the chitosan acetic acid solution is obtained after standing to remove air bubbles;

[0051]3) Add nicotinamide to the solution prepared in step 2), and stir evenly at 25°C to obtain the first solution;

[0052] 4) Add the lipophilic emulsifier into the liquid oil, and stir evenly in a constant temperature water bath at 25°C to obtain the second solution;

[0053] 5) Heating the second solut...

Embodiment 1

[0057] Embodiment 1 comparative example:

[0058] That is, a 1% aqueous solution of nicotinamide is prepared.

[0059] The permeability data of the nicotinamide microcapsules obtained in the above-mentioned Example 1 and the comparative example obtained in Example 1 containing 1% nicotinamide aqueous solution were measured, and the results are shown in the following table:

[0060]

Embodiment 2

[0062] Based on 1000g of formula raw materials, take 50g of nicotinamide, 300g of lipophilic emulsifier, 100g of chitosan, 100g of glacial acetic acid, 300g of water, 1g of glutaraldehyde, and 149g of liquid oil.

[0063] Described lipophilic emulsifier is ceteareth-25;

[0064] Described liquid grease is isopropyl myristate;

[0065] The steps of preparation method are as follows:

[0066] 1) glacial acetic acid is dissolved in water to make acetic acid solution;

[0067] 2) Chitosan is added to the acetic acid solution prepared in step 1), heated at 60° C. to completely dissolve, and the chitosan acetic acid solution is obtained after standing to remove air bubbles;

[0068] 3) Add nicotinamide to the solution prepared in step 2), and stir at 50°C to obtain the first solution;

[0069] 4) Add the lipophilic emulsifier into the liquid oil, and stir evenly in a constant temperature water bath at 60°C to obtain the second solution;

[0070] 5) Heating the second solution at...

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Abstract

The invention provides a nicotinamide microcapsule. The nicotinamide microcapsule is prepared from the following components in percentage by mass: 0.1%-5% of nicotinamide, 1%-30% of an oleophylic emulsifying agent, 1%-10% of chitosan, 1%-10% of glacial acetic acid, 1%-30% of water, 0.005%-0.1% of glutaraldehyde and the balance of liquid-state grease. The invention further provides a preparation method of the nicotinamide microcapsule. The preparation method comprises the following steps: heating and dissolving nicotinamide, chitosan and glacial acetic acid into water, so as to prepare a water-phase component; mixing the oleophylic emulsifying agent with the liquid-state grease, heating, and uniformly dispersing, so as to prepare an oil-phase component; slowly adding the water-phase component into the oil-phase component while stirring, so as to prepare an uniform emulsion; and adding glutaraldehyde into the emulsion for curing, and sequentially carrying out centrifugation, ethanol and petroleum ether washing and acetone dispersion and airing, so as to obtain the nicotinamide microcapsule. The nicotinamide microcapsule provided by the invention has good degree of sphericity, biocompatibility, safety and slow release effect and is gentle to the skin, and the stimulation of high-concentration nicotinamide to skin is effectively reduced.

Description

technical field [0001] The invention belongs to the field of cosmetics and relates to a microcapsule, in particular to a nicotinamide microcapsule and a preparation method thereof. Background technique [0002] Niacinamide, a derivative of vitamin B3, is a recognized skin anti-aging ingredient in the field of cosmetic dermatology, and has attracted more and more attention in recent years. It can lighten and prevent dull skin, yellowing, and disheveled skin in the early aging process; it can also repair the damaged stratum corneum lipid barrier and improve skin resistance; it also has a deep water-locking effect, so it contains Niacinamide Skin care products have strong water-locking and moisturizing effects; enlarged pores are one of the skin texture problems, and topical niacinamide can reduce the production of fatty acids and triglycerides in sebum, thereby shrinking pores and reducing the severity of acne. Degree; Niacinamide can enhance the skin barrier function and red...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/67A61K8/11A61Q19/08A61Q19/00
CPCA61K8/736A61K8/11A61K8/675A61Q19/00A61Q19/08
Inventor 张婉萍赵晓伟欧文华朱海洋
Owner SHANGHAI INST OF TECH
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