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Nanometer material based on pillararene and up-conversion nanocrystalline self-assembly as well as preparation method and application of nanometer material

A technology of nanomaterials and nanocrystals, applied in chemical instruments and methods, luminescent materials, etc., can solve the problems that are difficult to meet the needs of integrated diagnosis and treatment of clinical fluorescence imaging anticancer drugs, the limitations of preparation technology, components, structures and application performance, and the difficulties Obtain issues such as nanoscale structure and performance, and achieve the effect of high material assembly efficiency, good consistency, and fewer steps

Active Publication Date: 2017-06-13
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the existing technology has limitations in many aspects such as preparation technology, components, structure and application performance. Diagnosis and treatment integration needs for cancer drug delivery

Method used

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  • Nanometer material based on pillararene and up-conversion nanocrystalline self-assembly as well as preparation method and application of nanometer material
  • Nanometer material based on pillararene and up-conversion nanocrystalline self-assembly as well as preparation method and application of nanometer material
  • Nanometer material based on pillararene and up-conversion nanocrystalline self-assembly as well as preparation method and application of nanometer material

Examples

Experimental program
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Effect test

Embodiment 1

[0030] A kind of based on water-soluble column [5] arene ammonium salt and the surface is coated with inert NaGdF that the present embodiment provides 4 A layer of rare earth erbium-doped up-conversion nanocrystal self-assembled nanomaterial and a preparation method thereof, comprising the following steps:

[0031] (1) Prepare 10mg of oil-soluble NaYF with a particle size of 30-35nm 4 :Yb,Er@NaGdF 4 Disperse in cyclohexane, add an equal volume of water and a small amount of dilute hydrochloric acid to adjust the pH to 3-4, react at room temperature for 3 hours to remove the oleic acid ligand, and modify the surface to be coated with inert NaGdF 4 layer of water-soluble nanocrystals; then, 0.5 g of 15-carboxy-N,N,N-trimethylpentadecane-1-ammonium bromide (C 16 h 30 o 2NBr) was dissolved in 10mL of water and fully dissolved under the condition of heating at 50°C. After cooling to room temperature, it was added to the above-mentioned modified water-soluble nanocrystals, stirr...

Embodiment 2

[0038] A kind of water-soluble column [5,6] arene ammonium salt and the surface is coated with inert NaGdF that the present embodiment provides 4 The rare earth thulium-doped up-conversion nanocrystal self-assembled nanomaterial, preparation method and application thereof are basically the same as in Example 1, except that it includes the following steps:

[0039] (1) Prepare 15mg of oil-soluble NaYF with a particle size of 30-35nm 4 :Yb,Tm@NaGdF 4 Disperse in cyclohexane, add an equal volume of water and a small amount of dilute hydrochloric acid to adjust the pH to 3-4, react at room temperature for 5 hours to remove the oleic acid ligand, and modify the surface to be coated with inert NaGdF 4 layer of water-soluble nanocrystals; then, 0.4 g of 15-carboxy-N,N,N-trimethylpentadecane-1-ammonium bromide (C 16 h 30 o 2 NBr) was dissolved in 12mL of water and fully dissolved under the condition of heating at 70°C. After cooling to room temperature, it was added to the above-m...

Embodiment 3

[0043] A kind of water-soluble column [5,6] arene ammonium salt and the surface is coated with inert NaNdF that this embodiment provides 4 The rare earth thulium-doped up-conversion nanocrystal self-assembled nanomaterial, preparation method and application thereof are basically the same as those in Examples 1 and 2, except that the following steps are included:

[0044] (1) Prepare 13mg of oil-soluble NaYF with a particle size of 30-35nm 4 :Yb,Tm@NaNdF 4 Disperse in cyclohexane, add an equal volume of water and a small amount of dilute hydrochloric acid to adjust the pH to 3-4 and react at room temperature for 4 hours to remove the oleic acid ligand, oil-soluble NaYF 4 :Yb,Tm@NaNdF 4 Modified to water-soluble NaYF 4 :Yb,Tm@NaNdF 4 , and then, 0.5g of 15-carboxy-N,N,N-trimethylpentadecane-1-ammonium bromide (C 16 h 30 o 2 NBr) was dissolved in 10mL of water and fully dissolved under the condition of heating at 50°C. After cooling to room temperature, it was added to the...

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Abstract

The invention discloses a nanometer material based on pillararene and up-conversion nanocrystalline self-assembly as well as a preparation method and application of the nanometer material. The nanometer material is self-assembled by pillararene and up-conversion nanocrystalline, wherein an inert NaGdF4 layer or an inert NaNdF4 layer is coated on the surface of the up-conversion nanocrystalline; and the surface of the inert NaGdF4 layer or the inert NaNdF4 layer is modified by carboxyl modified cetyl trimethyl ammonium bromide. The preparation method is simple, and the repeatability is high. The nanometer material has diagnosis and treatment integrated functions, can be applied to preparing imaging agents for fluorescence imaging or magnetic resonance imaging, has drug delivery and pH-responsive release effects and can serve as a drug preparation carrier.

Description

technical field [0001] The invention belongs to the technical field of nano-biological materials, relates to a nano-material and its preparation method and application, in particular to a self-assembled nano-material and its preparation method and application. Background technique [0002] In recent years, fluorescence imaging has become one of the research hotspots in optical imaging technology, because fluorescence imaging has the advantages of high sensitivity and no damage to cells or biological tissues. Among them, rare earth-doped upconversion luminescent nanomaterials have attracted widespread attention as an emerging fluorescent material, because they are usually excited by low-energy light (usually near-infrared light 980nm) and emit high-energy light (red Light, green light, near-infrared light 800nm), these advantages can eliminate biological background fluorescence interference and low signal-to-noise ratio, so that it can be widely used in a series of biological...

Claims

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Application Information

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IPC IPC(8): C09K11/85
CPCC09K11/7772
Inventor 孙丽宁施利毅李海宏魏若艳赵磊刘金亮
Owner SHANGHAI UNIV
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