Procyanidine microcapsule and preparation method thereof

A technology of proanthocyanidins and microcapsules, which can be used in capsule delivery, pharmaceutical formulations, cosmetic preparations, etc. It can solve the problems of destruction and thermal degradation of proanthocyanidins, so as to promote absorption and penetration, protect structural integrity, stability, and sphericity Good results

Inactive Publication Date: 2017-06-16
SHANGHAI INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Aiming at the above-mentioned technical problems in the prior art, the present invention provides a kind of proanthocyanidin microcapsule and its preparation method, and described this kind of proanthocyanidin microcapsule and its preparation method should solve the proanthocyanidin encapsulated proanthocyanidin in the prior art under high temperature. Technical problems prone to thermal degradation and strong damage under direct sunlight

Method used

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  • Procyanidine microcapsule and preparation method thereof
  • Procyanidine microcapsule and preparation method thereof
  • Procyanidine microcapsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Based on 1000g of formula raw materials, take 1g of proanthocyanidin, 10g of lipophilic emulsifier, 10g of chitosan, 10g of glacial acetic acid, 10g of water, 0.05g of glutaraldehyde, and 958.95g of liquid oil.

[0050] Described lipophilic emulsifier is ceteareth-6;

[0051] The liquid oil is caprylic capric triglyceride;

[0052] The steps of preparation method are as follows:

[0053] 1) glacial acetic acid is dissolved in water to make acetic acid solution;

[0054] 2) Chitosan is added to the acetic acid solution prepared in step 1), heated at 30° C. to dissolve completely, and the chitosan acetic acid solution is obtained after standing to remove air bubbles;

[0055] 3) Add proanthocyanidins to the solution prepared in step 2), and stir evenly at 25°C to obtain solution a;

[0056] 4) Add the lipophilic emulsifier into the liquid oil, and stir evenly in a constant temperature water bath at 25°C to obtain solution b;

[0057] 5) Heat solution b at a constant tem...

Embodiment 2

[0066] Based on 1000g of formula raw materials, take 50g of proanthocyanidins, 300g of lipophilic emulsifier, 100g of chitosan, 100g of glacial acetic acid, 300g of water, 1g of glutaraldehyde, and 149g of liquid oil.

[0067] Described lipophilic emulsifier is ceteareth-25;

[0068] Described liquid grease is isopropyl myristate;

[0069] The steps of preparation method are as follows:

[0070] 1) glacial acetic acid is dissolved in water to make acetic acid solution;

[0071] 2) Chitosan is added to the acetic acid solution prepared in step 1), heated at 60° C. to completely dissolve, and the chitosan acetic acid solution is obtained after standing to remove air bubbles;

[0072] 3) Add proanthocyanidins to the solution prepared in step 2), and stir at 50°C to obtain solution a;

[0073] 4) Add the lipophilic emulsifier into the liquid oil, and stir evenly in a constant temperature water bath at 60°C to obtain solution b;

[0074] 5) Heat solution b at a constant tempera...

Embodiment 3

[0079] Based on 1000g of formula raw materials, take 25g of proanthocyanidins, 150g of lipophilic emulsifier, 50g of chitosan, 50g of glacial acetic acid, 150g of water, 0.5g of glutaraldehyde, and 574.5g of liquid oil.

[0080] Described lipophilic emulsifier is polyglyceryl-2 triisostearate;

[0081] Described liquid grease is isopropyl palmitate;

[0082] The steps of preparation method are as follows:

[0083] 1) glacial acetic acid is dissolved in water to make acetic acid solution;

[0084] 2) Chitosan is added to the acetic acid solution prepared in step 1), heated at 45° C. to completely dissolve, and the chitosan acetic acid solution is obtained after standing to remove air bubbles;

[0085] 3) Add proanthocyanidins to the solution prepared in step 2), and stir at 40°C to obtain solution a;

[0086] 4) Add the lipophilic emulsifier into the liquid oil, and stir evenly in a constant temperature water bath at 40°C to obtain solution b;

[0087] 5) Heat solution b at...

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Abstract

The invention discloses a procyanidine microcapsule. The procyanidine microcapsule is prepared from 0.1 to 5% of procyanidine, 1 to 30% of a lipophilic emulsifier, 1 to 10% of chitosan, 1 to 10% of glacial acetic acid, 1 to 30% of water, 0.005 to 0. 1% of glutaraldehyde and the balance of liquid fat all in percent concentration by mass. The invention further provides a preparation method of the procyanidine microcapsule, comprising the following steps: heating and dissolving procyanidine, chitosan and glacial acetic acid in water to obtain an aqueous-phase component; carrying out hybrid heating on the lipophilic emulsifier and liquid fat and uniformly dispersing to obtain an oil-phase component; slowly adding the aqueous-phase component to the oil-phase component while stirring to obtain uniform emulsion; adding glutaraldehyde to the emulsion to be solidified, then successively carrying out centrifugation and washing with ethanol and petroleum ether, dispersing and air-drying acetone to obtain the procyanidine microcapsule. According to the procyanidine microcapsule disclosed by the invention, procyanidine can be separated from the external environment to effectively avoid strong destructive effects on procyanidine caused by external environment of straight sunshine and the like.

Description

technical field [0001] The invention belongs to the field of fine chemical industry and relates to a microcapsule, specifically a proanthocyanidin microcapsule and a preparation method thereof. Background technique [0002] Proanthocyanidins belong to condensed tannins, which are polyphenolic compounds widely present in the core, skin or seeds of various plants. [0003] Proanthocyanidins are widely used in the fields of food, medicine and cosmetics. [0004] In the field of medicine, because proanthocyanidins have anticancer activity and cardiovascular protection function, they are used as active ingredients of anticancer and cardiovascular disease drugs. [0005] In the field of food, proanthocyanidins are used as a natural preservative to extend the shelf life of food; abroad, they are widely used in health foods such as lowering blood pressure, lowering blood fat, anti-tumor, and strengthening the brain; they are also used as ingredients or additives in ordinary foods ...

Claims

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Application Information

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IPC IPC(8): A61K8/49A61K8/11A61K8/73A61K8/36A61K8/33A61K8/86A61K8/37A61Q19/00A61Q19/02A61Q19/08A61K31/352A61K9/48A61K47/36A61K47/12A61K47/08A61K47/10A61K47/14A61P35/00A61P9/00A23L33/10
CPCA61K8/498A61K8/11A61K8/33A61K8/36A61K8/37A61K8/736A61K8/86A61K9/4816A61K31/352A61K47/08A61K47/10A61K47/12A61K47/14A61K47/36A61K2800/56A61Q19/00A61Q19/02A61Q19/08
Inventor 张婉萍赵晓伟李玲玉朱海洋
Owner SHANGHAI INSTITUTE OF TECHNOLOGY
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