Unlock instant, AI-driven research and patent intelligence for your innovation.

A process for extracting hesperidin from tangerine peel and its application in the preparation of blood lipid-lowering drugs

A technology of hesperidin and tangerine peel, which is applied in the field of preparation of blood lipid-lowering drugs, can solve the problems that are not suitable for industrial mass production, difficult to control temperature changes, and unsuitable for industrial production, etc., and achieve simple and feasible extraction process and reduce chemical substances The effect of using and improving the leaching rate

Active Publication Date: 2019-08-06
李潇
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the Soxhlet extraction method has the advantage of simple extraction process, but the progress of the experimental reaction is slow, multiple recrystallization extractions are required, and the solvent consumption is large
The alkali extraction and acid precipitation method has the advantages of saving economy and simple process, but its reaction time is long and it is easy to pollute the environment, so it is not suitable for industrial production
The microwave extraction method is less harmful to the environment, but the temperature change is not easy to control during the microwave extraction process, and it is not suitable for industrial mass production

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A process for extracting hesperidin from tangerine peel, comprising the steps of:

[0019] Take tangerine peel, crush it, and pass through a 200-mesh sieve to obtain tangerine peel powder, place it in a reaction kettle, control the pressure in the reaction kettle to 2MPa, the temperature is 120°C, keep the temperature and pressure for 3min, then take it out, cool to room temperature, and then add tangerine peel powder 10 times the weight of calcium hydroxide aqueous solution with a concentration of 0.6g / L and cellulase (20000u / g) accounting for 0.1wt% of orange peel powder, stirred at 200rpm for 3h, and then allowed to stand for 1h; heated to 80°C, kept for 15min, Cool down to room temperature, add hydrochloric acid to adjust the pH to 5.8, let it stand for 10 hours, filter, collect the precipitate, then add 10 times the weight of deionized water at 70°C, stir to dissolve, put it on a macroporous adsorption resin column, let it stand for 20 minutes, and use Elute with 5...

Embodiment 2

[0021] A process for extracting hesperidin from tangerine peel, comprising the steps of:

[0022] Take tangerine peel, crush it, and pass through a 200-mesh sieve to obtain tangerine peel powder, put it in a reaction kettle, control the pressure in the reaction kettle to 1.5MPa, the temperature is 140°C, keep the heat and pressure for 3min, then take it out, cool to room temperature, and then add tangerine peel Powder 10 times the weight of calcium hydroxide aqueous solution with a concentration of 0.7g / L and cellulase (20000u / g) accounting for 0.2wt% of tangerine peel powder, stirred at 200rpm for 3h, and then allowed to stand for 2h; heated to 80°C and kept for 10 -15min, lower to room temperature, add hydrochloric acid to adjust the pH to 5.8, let it stand for 10h, filter, collect the precipitate, then add 10 times the weight of deionized water at 70°C, stir to dissolve, put it on a macroporous adsorption resin column, let it stand for 30min Finally, it was eluted with 50% ...

Embodiment 3

[0024] A process for extracting hesperidin from tangerine peel, comprising the steps of:

[0025] Take tangerine peel, crush it, and pass through a 200-mesh sieve to obtain tangerine peel powder, place it in a reaction kettle, control the pressure in the reaction kettle to 1MPa, the temperature is 140°C, keep the temperature and pressure for 4min, then take it out, cool to room temperature, and then add tangerine peel powder 10 times the weight of calcium hydroxide aqueous solution with a concentration of 0.6g / L and cellulase (20000u / g) accounting for 0.15wt% of tangerine peel powder, stirred at 200rpm for 5h, and then allowed to stand for 1h; heated to 80°C, kept for 10- 15min, lower to room temperature, add hydrochloric acid to adjust the pH to 5.8, let it stand for 9h, filter, collect the precipitate, then add 10 times the weight of deionized water at 70°C, stir to dissolve, put it on a macroporous adsorption resin column, and let it stand for 26min , eluted with 50% (v / v) ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of extraction of hesperidin, and discloses a process for extracting the hesperidin from pericarpium citri reticulatae. The process comprises the following steps: smashing, heat preservation and pressure retaining, cooling, alkaline liquid and enzyme treatment, stirring and standing, neutralization, redissolving, resin adsorption, elution and evaporation and drying. By the adoption of a multi-factor orthogonal test, the extraction process is optimized, and the yield and the purity are improved.

Description

technical field [0001] The invention belongs to the technical field of hesperidin extraction, and in particular relates to a process for extracting hesperidin from tangerine peel and its application in the preparation of blood lipid-lowering drugs. Background technique [0002] Chinese aliases of hesperidin: hesperidin; dihydroflavone glycosides; Hesperidin is one of the main active ingredients of tangerine peel. The pure product is white needle-like crystals with the molecular formula C 28 h 34 o 15 . Studies have shown that hesperidin has physiological functions such as anti-oxidation, anti-allergy, antibacterial and anti-inflammatory, anti-virus and anti-cancer, prevention of cardiovascular diseases, lowering blood pressure, lowering low-density cholesterol, etc., and has high medicinal value. In addition, hesperidin is also used in the food and cosmetic industries as a natural oxidizing agent. [0003] Currently, the extraction techniques of hesperidin mainly includ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/07C07H1/08A61K31/7048A61P3/06
CPCA61K31/7048C07H1/08C07H17/07
Inventor 李潇
Owner 李潇