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Continuous production method and device of sodium gluconate

The technology of a sodium gluconate and production method is applied in the continuous production method and device field of sodium gluconate, which can solve the problems of increasing enzyme consumption, large enzyme addition amount, high cost, etc., and achieve saving of addition amount, increase of concentration, The effect of improving productivity

Inactive Publication Date: 2017-06-20
山东福洋生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Yet at present, the shortcoming of double-enzyme method to produce sodium gluconate is that enzyme activity can be reduced in production process, and reaction will stop after reducing to a certain extent, so enzyme addition is large, and cost is high (Novozymes company produces enzyme addition amount Glucose oxidase 3.5kg / T dry matter, catalase 3.5kg / T dry matter)
In addition, the current dual-enzyme method is a single-batch production (single-batch dual-enzyme method), that is, after a batch of reaction is completed, the reaction solution must be discharged, and after the enzyme is deactivated, the raw material is added to react with the double-enzyme, which will also increase the consumption of the enzyme. quantity

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  • Continuous production method and device of sodium gluconate

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Effect test

Embodiment 1

[0040] The present embodiment provides a continuous production device 100 of sodium gluconate, such as figure 1 As shown, it includes: a reaction tank 110, a first buffer tank 120, a second buffer tank 130 and a storage tank 140, and the drain port 111 of the reaction tank 110 can be optionally connected with the first buffer tank 120 or the second buffer tank 130 Connect, the reaction tank 110 has the first feed port 112 (they walk different feed ports for accessing glucose, glucose oxidase, catalase, and sodium hydroxide solution, and different lines represent different feeds as shown in the figure) tube), the first buffer tank 120 and the second buffer tank 130 all have the second feed port 121 for adding sodium hydroxide solution; The third feed port 141 for the reaction liquid in 130.

Embodiment 2

[0042] The present embodiment provides a kind of continuous production method of sodium gluconate, it adopts the continuous production device 100 as shown in embodiment 1, and it comprises:

[0043] a. At 200m 3 Add 130m to the reaction tank 3 Glucose (concentration: 350g / L), 10kg defoamer, 52.5kg glucose oxidase (enzyme activity: 8.736 million U / ml), 52.5kg catalase (enzyme activity: 375,000 U / ml) , start the reaction, add 33wt% sodium hydroxide to control the pH of the reaction solution and maintain it at 5.3, the tank pressure is controlled at 0.14MPa, and the controlled rotating speed and air volume maintain 35% of dissolved oxygen in the tank.

[0044] b. When the enzyme activity of glucose oxidase in the reaction tank drops to 3000U / mL, start feeding glucose oxidase and catalase with a mass ratio of 1:1, and control the flow acceleration rate to maintain the concentration of glucose oxidase in the reaction tank. The enzyme activity is 3050U / mL.

[0045] c. After the r...

Embodiment 3

[0051] The present embodiment provides a kind of continuous production method of sodium gluconate, it adopts the continuous production device 100 as shown in embodiment 1, and this method comprises:

[0052] a. At 200m 3 Add 130m to the reaction tank 3 Glucose (concentration: 300g / L), 10kg defoamer, 50kg glucose oxidase (enzyme activity: 9.5 million U / ml), 50kg catalase (enzyme activity: 380,000 U / ml), start To react, add 33wt% sodium hydroxide to control the pH of the reaction solution to maintain 5.5, the tank pressure to be controlled at 0.14MPa, and control the rotating speed and air volume to maintain 25% of dissolved oxygen in the tank.

[0053] b. When the enzyme activity of glucose oxidase in the reaction tank drops to 2500U / mL, start feeding glucose oxidase and catalase with a mass ratio of 1:0.5, and control the flow acceleration to maintain the concentration of glucose oxidase in the reaction tank. The enzyme activity is 3000U / mL.

[0054] c. After the reaction w...

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Abstract

The invention provides a continuous production method and device of sodium gluconate, and relates to the field of production of sodium gluconate. The continuous production method comprises the following steps: introducing glucose, glucose oxidase and catalase to a reaction tank and conducting an enzyme-catalyzed reaction, and controlling pH value of reaction liquid to 5.0-5.5 by adding a sodium hydroxide solution in a fed-batch mode, wherein during the enzyme-catalyzed reaction, the glucose, the glucose oxidase and the catalase are added to the reaction tank in a fed-batch mode. With the application of the production method, the enzyme-catalyzed reaction of the sodium gluconate can be continuously implemented, so that production efficiency is improved, addition amounts of the glucose oxidase and the catalase are reduced and production cost is reduced. The continuous production device comprises the reaction tank and at least two buffer tanks, wherein an outlet of the reaction tank communicates with the buffer tanks; and the reaction tank is provided with a material inlet. With the application of the device, the continuous production of the sodium gluconate is achieved, and production efficiency is improved.

Description

technical field [0001] The invention relates to the field of sodium gluconate production, in particular to a continuous production method and device for sodium gluconate. Background technique [0002] Sodium gluconate is widely used in industry. It can be used in food, medicine, chemical industry, water treatment and other industries. It can be used as high-efficiency retarder and high-efficiency water reducer in the concrete industry. [0003] At present, the production methods of sodium gluconate mainly include microbial fermentation method, electrolysis method, catalytic oxidation method, double enzyme method and other methods. Due to the mild conditions and easy operation of the microbial method, it is widely used. The fermentation of gluconic acid and its salts (such as sodium gluconate, calcium gluconate, etc.) is mainly carried out by mold fermentation. The process is to add a large amount of medium to the fermenter and then insert the seed liquid for fermentation. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P7/58C12M1/40
CPCC12P7/58C12M21/18C12M23/58
Inventor 赵伟曹大鹏方健杨健宋金松
Owner 山东福洋生物科技股份有限公司