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Faropenem sodium capsule

A technology for faropenem sodium and faropenem, which is applied in the field of pharmaceutical preparations, can solve the problems of not using direct dry granulation, poor stability and the like, and achieves the effects of good fluidity, small difference in loading and low cost

Inactive Publication Date: 2017-06-27
HAINAN HONZ PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method does not go through the process of exposure to heat and humidity, and is especially suitable for some drugs with poor stability under heat and humidity conditions
However, faropenem sodium has not been studied using direct dry granulation

Method used

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  • Faropenem sodium capsule
  • Faropenem sodium capsule
  • Faropenem sodium capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Prescription (specification: 0.1g):

[0022]

[0023] Preparation:

[0024] (1), the faropenem sodium and the dispersant (lactose monohydrate) are pulverized and sieved together;

[0025] (2), mix the mixture prepared in step (1) with filler (microcrystalline cellulose), dry binder (hypromellose), dry press with a dry granulator, and then the obtained bar Blocks are made into granules by rocking granulators;

[0026] (3), add lubricant (magnesium stearate) and mix homogeneously;

[0027] (4), put into hard capsule shell and get final product.

Embodiment 2

[0029] Prescription (specification: 0.1g):

[0030]

[0031] The preparation method is the same as in Example 1.

Embodiment 3

[0033] Prescription (specification: 0.1g):

[0034]

[0035] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention provides a faropenem sodium capsule. The faropenem sodium capsule is characterized by being prepared from the following components in parts by weight on the basis of faropenem: 100 parts of faropenem sodium, 300-400 parts of filler, 8.0-80 parts of lubricant, 100-200 parts of dispersing agent and 10-50 parts of dry adhesive. The faropenem sodium capsule is prepared through a dry granulation technology, and the prepared faropenem sodium capsule solves the defect that the existing capsule is poor in stability.

Description

technical field [0001] The invention relates to a solid pharmaceutical preparation, in particular to a faropenem sodium capsule. It belongs to the field of pharmaceutical preparations. Background technique [0002] Faropenem Sodium (Faropenem Sodium) is a penem-type β-lactam antibiotic, and is the first marketed broad-spectrum antibiotic that is stable to β-lactamase and can be taken orally. Like other β-lactam antibiotics, faropenem sodium plays a bactericidal effect by inhibiting the synthesis of bacterial cell walls. The drug has strong antibacterial activity, especially for Gram-positive bacteria such as Staphylococcus aureus, penicillin-resistant pneumococcus, streptococcus faecalis, and anaerobic bacteria such as Bacteroides fragilis, which is significantly better than the existing cephalosporins , such as cefoxitin, cefditoren, cefixime, cefaclor, etc. The activity against Gram-negative bacteria is similar to that of oral cephalosporins, and the anti-Pseudomonas ae...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/26A61K47/38A61K47/32A61K31/431A61P31/04
CPCA61K9/4858A61K9/4866A61K31/431
Inventor 何清王稳奇凌日金洪丽萍
Owner HAINAN HONZ PHARMA
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