Faropenem sodium capsule

Abstract

The invention provides a faropenem sodium capsule. The faropenem sodium capsule is characterized by being prepared from the following components in parts by weight on the basis of faropenem: 100 parts of faropenem sodium, 300-400 parts of filler, 8.0-80 parts of lubricant, 100-200 parts of dispersing agent and 10-50 parts of dry adhesive. The faropenem sodium capsule is prepared through a dry granulation technology, and the prepared faropenem sodium capsule solves the defect that the existing capsule is poor in stability.

Description

technical field [0001] The invention relates to a solid pharmaceutical preparation, in particular to a faropenem sodium capsule. It belongs to the field of pharmaceutical preparations. Background technique [0002] Faropenem Sodium (Faropenem Sodium) is a penem-type β-lactam antibiotic, and is the first marketed broad-spectrum antibiotic that is stable to β-lactamase and can be taken orally. Like other β-lactam antibiotics, faropenem sodium plays a bactericidal effect by inhibiting the synthesis of bacterial cell walls. The drug has strong antibacterial activity, especially for Gram-positive bacteria such as Staphylococcus aureus, penicillin-resistant pneumococcus, streptococcus faecalis, and anaerobic bacteria such as Bacteroides fragilis, which is significantly better than the existing cephalosporins , such as cefoxitin, cefditoren, cefixime, cefaclor, etc. The activity against Gram-negative bacteria is similar to that of oral cephalosporins, and the anti-Pseudomonas ae...

AI Technical Summary

Problems solved by technology

This method does not go through the process of exposure to heat and humidity, and is especially suitable for some drugs with poor stability under heat and humidity conditions

However, faropenem sodium has not been studied using direct dry granulation

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