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Method for extracting and separating hydrastine from corydalis impatiens

A technique for goldensealine and goldenseal is applied in the field of mass production of high-purity goldenseal, can solve problems such as low yield of goldenseal, and achieve the effects of high purity, high yield and improved extraction rate

Active Publication Date: 2017-07-11
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, there are only literatures on the extraction of total alkaloids from Corydalis cypress, while there are few literatures on the separation of hydrascine, and the yield of hydrascine obtained is less than 1 / 10,000

Method used

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  • Method for extracting and separating hydrastine from corydalis impatiens
  • Method for extracting and separating hydrastine from corydalis impatiens
  • Method for extracting and separating hydrastine from corydalis impatiens

Examples

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Embodiment example 1

[0027] Firstly, dry the whole herb of Corydalis saibei with a weight of about 5.0kg, crush the whole herb to 40 mesh, add Na with a pH of 11 2 CO 3 Solution 10L, soak for 4h, pass through a 40-mesh sieve after drying. Put the alkalized Corydalis saibei powder into the extraction kettle, adjust the extraction temperature to 35°C, and the extraction pressure to 20MPa, use 90% ethanol as the entrainer, adjust the flow rate of the entrainer to 1.0mL / min, and extract 2 Hour. After the extraction was completed, the solvent was recovered under reduced pressure. Dissolve 50 g of the alkaloid extract above with 1 L of hydrochloric acid aqueous solution, adjust the pH to 2.0, control the pressure to 0.5 MPa, and use ceramic microfiltration at a temperature of 25°C. The filtrate was collected to keep the temperature constant, and ultrafiltered with a hollow fiber ultrafiltration membrane with a molecular weight cut-off of 6000D, and the pressure was controlled to be 0.3MPa. The obtai...

Embodiment example 2

[0029] Firstly, dry the whole herb of Corydalis saibei with a weight of about 5.0kg, crush the whole herb to 60 mesh, add Na with a pH of 10 2 CO 3 Solution 12L, soak for 4 hours, pass through a 60-mesh sieve after drying. Add the basified Corydalis saibei powder into the extraction kettle, adjust the extraction temperature to 45°C, the extraction pressure to 25MPa, use 90% ethanol as the entrainer, adjust the flow rate of the entrainer to 1.5mL / min, and extract 4 Hour. After the extraction was completed, the solvent was recovered under reduced pressure. Dissolve 45 g of the alkaloid extract above with 1.8 L sulfuric acid aqueous solution, adjust the pH value to 3.0, control the pressure to 0.6 MPa, and use ceramic microfiltration at a temperature of 30°C. The filtrate was collected to keep the temperature constant, and ultrafiltered with a hollow fiber ultrafiltration membrane with a molecular weight cut-off of 8000D, and the pressure was controlled to be 0.2MPa. The obta...

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Abstract

The invention discloses a method for extracting and separating hydrastine from corydalis impatiens, and belongs to the technical field of natural product extraction and purification. According to the method, a papaveraceae corydalis plant corydalis impatiens is adopted as a raw material, and crushing alkalization, supercritical CO2 extraction, membrane separation technology, cation exchange resin and re-crystallization are combined to achieve the separation of the high purity hydrastine from corydalis impatiens. According to the present invention, the toxic reagent consumption is low, the yield is up to 0.43%, and the purity of the hydrastine can achieve 99.0%.

Description

technical field [0001] The invention relates to a method for extracting and isolating hydrantine from Corydalis genus Papaveraceae, in particular to a method for preparing a large amount of high-purity hydrantine from Corydalis cypress. Background technique [0002] Corydalis impatiens is a plant of the genus Corydalis in the family Papaveraceae. It is recorded in the volume of "Chinese Materia Medica" Tibetan medicine. Its roots, stems, leaves and flowers can be used as medicine. Antipruritic, expelling wind and Qi and other effects. Corydalis saibei is widely distributed in Qinghai, Tibet, Gansu, Sichuan and Inner Mongolia, and is a commonly used medicinal material in Tibetan medicine. The plants of this genus mainly contain alkaloids of structural types such as benzyl isoquinolines, phenol isoquinolines, benzophenanthridines, berberines, aporphyrins, protolines and spirobenzylisoquinolines. . [0003] Hydrastine, also known as berberine, is a phenolic isoquinoline alka...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D491/056
CPCC07D491/056Y02P20/54
Inventor 廖志新陈慧枫张晶张姗姗公程程
Owner SOUTHEAST UNIV
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