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A kind of tetraalkyl peroxycarboxylate ammonium salt compound and its preparation method and application

A technology of ammonium peroxycarboxylate and tetraalkylperoxycarboxylate, applied in the field of medicinal chemistry, can solve the problems of poor permeability, short disinfection time and the like, and achieve the effect of good permeability

Active Publication Date: 2021-04-02
CHANGJIANGMAI MEDICINE SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by this invention is to provide a kind of tetraalkyl peroxycarboxylate ammonium salt compound, which has the good advantages of the oxidation of peroxide disinfectant and the good permeability of quaternary ammonium salt, not only realizes rapid sterilization, At the same time, it has the characteristics of long-term antibacterial, which fully overcomes the shortcomings of existing peroxide disinfectants with poor permeability and short disinfection time.

Method used

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  • A kind of tetraalkyl peroxycarboxylate ammonium salt compound and its preparation method and application
  • A kind of tetraalkyl peroxycarboxylate ammonium salt compound and its preparation method and application
  • A kind of tetraalkyl peroxycarboxylate ammonium salt compound and its preparation method and application

Examples

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Effect test

Embodiment 1

[0035] (1) In a 1000ml four-necked flask equipped with a thermometer, a mechanical stirrer, a reflux condenser and a constant pressure funnel, add 120g of acetic acid, 10g of organic phosphoric acid and 2g of disodium edetate;

[0036] (2) Start the stirrer, and when the temperature of the system reaches 5° C., start to drop 150 g of 50% hydrogen peroxide. Add dropwise in 1 hour;

[0037] (3) continue to react for 12 hours;

[0038] (4) Keeping the temperature of the system at 10°C, add tetrabutylammonium hydroxide dropwise until the system is neutral;

[0039] (5) Continue to react for 2 hours under stirring to obtain tetrabutyl ammonium peroxyacetate aqueous solution, which can be directly used for disinfection;

[0040] (6) Remove moisture by distillation under reduced pressure, and refine the product tetrabutyl ammonium peroxyacetate with methanol.

Embodiment 2

[0042] (1) In a 1000ml four-neck flask equipped with a thermometer, a mechanical stirrer, a reflux condenser and a constant pressure funnel, add 110g propionic acid, 5g p-toluenesulfonic acid and 0.5g organic phosphoric acid;

[0043] (2) Start the agitator, and when the temperature of the system reaches 15° C., start to drop 120 g of 50% hydrogen peroxide. Add dropwise in 1 hour;

[0044] (3) continue to react for 12 hours;

[0045] (4) Keeping the temperature of the system at 10° C., dropwise adding tetraethylammonium hydroxide until the system is neutral;

[0046] (5) Continue to react for 2 hours under stirring to obtain tetraethyl ammonium peroxyacetate aqueous solution, which can be directly used for disinfection;

[0047] (6) Remove moisture by distillation under reduced pressure, and refine the product tetraethyl ammonium peroxyacetate with methanol.

Embodiment 3

[0049] (1) In a 1000ml four-necked flask equipped with a thermometer, a mechanical stirrer, a reflux condenser and a constant pressure funnel, add 130g valeric acid, 15g organic phosphoric acid and 5g disodium edetate;

[0050] (2) Start the agitator, and when the temperature of the system reaches 15° C., start to drop 180 g of 50% hydrogen peroxide. Add dropwise in 1 hour;

[0051] (3) Continue to react for 15 hours;

[0052] (4) Keeping the temperature of the system at 10°C, add tetrabutylammonium hydroxide dropwise until the system is neutral;

[0053] (5) Continue to react for 2 hours under stirring to obtain tetrabutyl ammonium peroxyvalerate aqueous solution, which can be directly used for disinfection;

[0054] (6) Remove moisture by distillation under reduced pressure, and refine the product tetrabutyl ammonium peroxyvalerate with methanol.

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Abstract

The invention discloses a tetra-alkyl ammonium carboxylate peroxide compound. The compound has the structure shown in the description, wherein R1, R2, R3, R4 and R5 are alkyls; the alkyls are linear alkyls, alkyls with side-chain groups, aryls or aralkyls. The tetra-alkyl ammonium carboxylate peroxide compound disclosed by the invention has a sterilizing function and also has the advantages of an oxidation effect of a peroxide disinfectant and good penetrability of quaternary ammonium salt; the compound realizes quick sterilization and has the characteristics of long-effect bacteriostasis.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular to a tetraalkyl peroxycarboxylate ammonium salt compound. Background technique [0002] Peroxide disinfectants have always been a major research object in the field of disinfectants. At present, peroxide disinfectants that have been used for disinfection and sterilization include peracetic acid, peroxyglutaric acid, potassium hydrogen persulfate, sodium percarbonate, Magnesium peroxide phthalate and hydrogen peroxide, etc. Peroxides are widely used for their high efficiency, low toxicity and virtually no residue. [0003] However, general peroxides have poor permeability, and their application in many fields has been greatly restricted. For example, in the medical field, for the disinfection of blood-contaminated surgical gowns, general peroxide disinfectants such as peracetic acid are difficult to achieve. In addition, once the common peroxide disinfectant is decomposed, it lo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C409/26C07C409/24C07C407/00C07C209/00C07C211/63A01N37/16A01N33/12A01P1/00A01P3/00
CPCA01N33/12A01N37/16C07C209/00C07C211/63C07C407/00C07C409/24C07C409/26
Inventor 戴彦榛史瑞雪王玉路王舒萌李芳李欢欢
Owner CHANGJIANGMAI MEDICINE SCI & TECH BEIJING