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A kind of preparation method of calcium salt mixture used as biological material

A technology for biological materials and mixtures, applied in phosphorus compounds, chemical instruments and methods, calcium carbonate/strontium/barium, etc., can solve the problems of complex process, particle agglomeration, difficult nano-size uniform mixing, etc., to achieve good process repeatability, Good crystallinity, the effect of avoiding agglomeration

Active Publication Date: 2019-05-31
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of method usually requires two synthesis, and the process is complicated; secondly, the two phases of hydroxyapatite and calcium carbonate are synthesized and then mechanically mixed, it is difficult to achieve uniform mixing at the nanometer scale, even if the two phases are synthesized at the nanoscale , the late mixing process will also lead to serious agglomeration of particles, affecting the final use effect

Method used

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  • A kind of preparation method of calcium salt mixture used as biological material
  • A kind of preparation method of calcium salt mixture used as biological material
  • A kind of preparation method of calcium salt mixture used as biological material

Examples

Experimental program
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Effect test

Embodiment 1

[0024] (1) Prepare 0.15mol / L phosphoric acid solution and 0.3mol / L calcium hydroxide suspension, control the calcium-phosphorus ratio to 2.0, add a certain amount of phosphoric acid solution to the calcium hydroxide suspension under strong stirring conditions In, aging for 12 hours after the completion of the reaction.

[0025] (2) Control the mol ratio of sodium carbonate to calcium hydroxide to be 0.167, add dropwise 50ml of 0.5mol / L sodium carbonate solution in the aging liquid, continue to react for 1 hour under stirring, then centrifuge, and the gained precipitate is placed in hydrothermal In the kettle, hydrothermal treatment was carried out at 160°C for 5 hours.

[0026] (3) Cool the hydrothermal kettle after the reaction in (2) to room temperature, wash the precipitate in the kettle with absolute ethanol, and dry the precipitate to obtain a mixture of hydroxyapatite and calcium carbonate.

Embodiment 2

[0028] (1) Prepare 0.12mol / L phosphoric acid solution and 0.3mol / L calcium hydroxide suspension, control the calcium-phosphorus ratio to 2.5, add a certain amount of phosphoric acid solution to the calcium hydroxide suspension under strong stirring conditions In, aging for 12 hours after the completion of the reaction.

[0029] (2) Control the mol ratio of sodium carbonate to calcium hydroxide to be 0.333, add dropwise 100ml of 0.5mol / L sodium carbonate solution in the aging liquid, continue to react for 1 hour under stirring, then centrifuge, and the gained precipitate is placed in hydrothermal In the kettle, hydrothermal treatment was carried out at 120°C for 5 hours.

[0030] (3) Cool the hydrothermal kettle after the reaction in (2) to room temperature, wash the precipitate in the kettle with absolute ethanol, and dry the precipitate to obtain a mixture of hydroxyapatite and calcium carbonate.

Embodiment 3

[0032] (1) Prepare 0.1mol / L phosphoric acid solution and 0.3mol / L calcium hydroxide suspension, control the calcium-phosphorus ratio to 3.0, add a certain amount of phosphoric acid solution to the calcium hydroxide suspension under strong stirring conditions In, aging for 12 hours after the completion of the reaction.

[0033] (2) Control the mol ratio of sodium carbonate to calcium hydroxide to be 0.444, add dropwise 133ml of 0.5mol / L sodium carbonate solution in the aging liquid, continue to react for 1 hour under stirring, then centrifuge, and the gained precipitate is placed in hydrothermal In the kettle, hydrothermal treatment was carried out at 140°C for 5 hours.

[0034] (3) Cool the hydrothermal kettle after the reaction in (2) to room temperature, wash the precipitate in the kettle with absolute ethanol, and dry the precipitate to obtain a mixture of hydroxyapatite and calcium carbonate.

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Abstract

The invention discloses a preparation method of a calcium salt mixture used as a biological material. The preparation method comprises the following steps of (1), adding a phosphoric acid solution into calcium hydroxide turbid liquid, and ageing after a reaction is finished, so as to obtain aged liquid; (2), dropwise adding a sodium carbonate solution into the aged liquid obtained in the step (1), entrifuging after reacting, and carrying out hydrothermal treatment on an obtained deposit; (3), after the hydrothermal treatment is finished, cooling the deposit to a room temperature, washing the deposit with absolute ethyl alcohol, and then oven-drying the deposit, so as to obtain the calcium salt mixture. In comparison with the prior art, according to the preparation method of the calcium salt mixture, which is provided by the invention, the composition of each phase of a final product can be directly controlled through regulating and controlling the ratio of raw materials; particles of obtained products hydroxyapatite and calcium carbonate are both in nano size, and further, are uniformly dispersed; the mixing of the hydroxyapatite and the calcium carbonate in the nano size is realized; problems of uneven mixing, agglomeration and the like which are easily generated in the direct mechanical mixing process of two phases are avoided.

Description

technical field [0001] The invention relates to a preparation method of a calcium salt mixture which can be used as a biological material, and belongs to the field of biomedical materials. Background technique [0002] Hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , HA) is the main inorganic component of human bones and teeth, has good biocompatibility and biodegradability, because of its unique physical and chemical properties and biological characteristics, it is widely used in bone tissue replacement materials, catalysts, ions Exchangers and sensors, etc. Calcium carbonate is a calcium salt widely used in the food industry and biological materials. It is often used as a calcium supplement, a raw material for making toothpaste and tooth powder, etc. Based on the common characteristics of the two phases, the mixture of hydroxyapatite and calcium carbonate plays an important role in bone cement reinforcement materials, bone tissue replacement materials, calcium source suppleme...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/32C01F11/18B82Y40/00
CPCB82Y40/00C01B25/325C01F11/18C01P2002/72C01P2004/04C01P2004/64
Inventor 董寅生肖夫兰耿银雪郭超黄志海储成林盛晓波
Owner SOUTHEAST UNIV