Nine-membered ring lactone derivative derived from marine fungi as well as preparation method and application thereof

A marine fungus, nine-membered ring technology, applied in the field of nine-membered ring lactone derivatives and its preparation, can solve side effects and other problems, achieve significant α-glucosidase inhibitory activity, and broad market application prospects

Active Publication Date: 2017-08-18
SUN YAT SEN UNIV
View PDF1 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs have more obvious gastrointestinal side effects, such as abdominal pain, bloating, diarrhea

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Nine-membered ring lactone derivative derived from marine fungi as well as preparation method and application thereof
  • Nine-membered ring lactone derivative derived from marine fungi as well as preparation method and application thereof
  • Nine-membered ring lactone derivative derived from marine fungi as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 9

[0024] Example 1 Preparation of nine-membered ring lactone derivatives

[0025] 1. The nine-membered ring lactone derivative of the present invention is isolated from the fermentation broth of the marine fungus Ascomycota sp. SK2YWS-L.

[0026] The marine fungus Ascomycota sp. SK2YWS-L was isolated from the fruit of Kandelia obovata, a mangrove plant in Guangxi, Guangxi, China. It was deposited in the China Center for Type Culture Collection on April 21, 2016, with the deposit number CCTCC M 2016217, deposited Address: Wuhan University, Wuhan (see patent 201610509145.3).

[0027] Specifically, the preparation method of the nine-membered ring lactone derivative is as follows:

[0028] (1) Seed culture of the fungus Ascomycota sp.SK2YWS-L: Make the culture medium into a test tube slope, pick the strains into the slope, and cultivate at 28°C for 3 days;

[0029] The composition of the culture medium by weight ratio is: glucose 0.3%, yeast extract 0.1%, peptone 0.5%, agar 2.5%, sodium chlo...

Embodiment 2 9

[0038] Example 2 In vitro α-glucosidase inhibition experiment of nine-membered ring lactone derivatives

[0039] 1. Test materials

[0040] P-Nitrophenol-α-glucoside (pNPG), purchased from aladdin reagent company; dipotassium hydrogen phosphate and potassium dihydrogen phosphate, purchased from aladdin reagent company; α-glucosidase, purchased from aladdin reagent company; Acarb Sugar was purchased from Aladdin Reagent Company; analytical pure DMSO was purchased from Guangzhou Chemical Reagent Factory; iMark microplate reader.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a nine-membered ring lactone derivative derived from marine fungi as well as a preparation method and application thereof. The structure formula of the nine-membered ring lactone derivative is shown as a formula (I) which is shown in the description. The compound is separated from the marine fungi Ascomycota sp. SK2YWS-L, has obvious alpha-glucosaccharase inhibition activity, has a broad market prospect in preparation of hypoglycemic drugs, especially preparation of drugs for treating type II diabetes.

Description

Technical field [0001] The invention belongs to the technical field of pharmaceutical compounds, and specifically relates to a nine-membered ring lactone derivative derived from marine fungi, and a preparation method and application thereof. Background technique [0002] Diabetes is a group of metabolic diseases characterized by high blood sugar. Hyperglycemia is caused by defective insulin secretion or impaired biological effects, or both. The long-term high blood sugar in diabetes causes chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves. With the improvement of living standards, unhealthy lifestyles and eating habits are gradually affecting people's quality of life. One of its serious consequences is the increasing number of diabetic patients. It is estimated that in 2030, there will be 439 million diabetic patients worldwide. [0003] At present, there is no cure for diabetes, but a variety of treatment methods ar...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07D407/04C12P17/16A61P3/10C12R1/645
CPCC12P17/162C07D407/04
Inventor 佘志刚刘昭明谭春兵陈森华黄锡山
Owner SUN YAT SEN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap