Method for preparing polyurethane-nanometer silver long-acting antibacterial film by modification after ultraviolet light irradiation

Abstract

The invention relates to a method for preparing a polyurethane-nano silver long-lasting antimicrobial film by a modification method after ultraviolet-irradiation. The method comprises the steps: (1) conducting a mixed reaction of diisocyanate and polytetrahydrofuran; adding an acetone solution containing a cross-linking agent and a chain extender, adding dimethylol propionic acid and a catalyst to react, and obtaining PU; adding a dimethylformamide solution of silver nitrate to a polyurethane solution, stirring evenly to form a film, conducting heat treatment, and obtaining a polyurethane-nano silver film; (2) reacting 4,4'-dihydroxybenzophenone with long chain haloalkane, and obtaining 4,4'-double-long chain alkoxy benzophenone; reacting the 4,4'-double-long chain alkoxy benzophenone with hydrazine hydrate, and obtaining 4,4'-double-long chain alkoxy benzophenone hydrazone; conducting oxidizing reaction on the 4,4'-double-long chain alkoxy benzophenone hydrazone, and obtaining long chain alkyl diazomethane; (3 ) dissolving the long-chain alkyl diazomethane in solvent, spraying on the surface of the polyurethane-nano-silver film, after ultraviolet-irradiation, and obtaining the product. The invention can achieve long-term anti-microbial.

Description

technical field [0001] The invention relates to a method for preparing a polyurethane-nanometer silver long-acting antibacterial film by a modification method after ultraviolet light irradiation, and belongs to the technical field of antibacterial materials. Background technique [0002] Polyurethane is an important class of medical polymer materials with excellent blood compatibility, good biological stability and mechanical properties. Fu Qiang et al. (Tan Hong, Li Jiehua, Fu Qiang. Design, preparation and performance of biomedical phospholipidated polyurethane. Chinese Science: Chemistry, 42(5), pp 661-675, 2012.) showed that polyurethane has the same properties as natural blood vessels The best matching compliance, especially for blood contact devices, has an irreplaceable role in surgical treatment. However, interventional medical polymer materials need to have long-term antibacterial properties, otherwise it is easy to cause postoperative infection in clinical applica...

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Problems solved by technology

However, this hydrophobic modification method requires special functional groups on the surface of the polymer, and in order to ensure the smooth implementation of subsequent modification reactions, the functional groups (such as alkynyl, alkenyl, azide, etc.) The chemical properties are often relatively active and prone to side reactions and deterioration, which makes the synthesis of this type of polymer difficult, and is not suitable for the surface modification of commonly used polyurethane materials.

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