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Copper, zinc, tin and sulfur quaternary nanocomposite with functions of microwave sensitization and nuclear magnetic imaging and preparation and application method thereof

A nanocomposite material, microwave sensitization technology, applied in medical preparations containing active ingredients, wave energy or particle radiation treatment materials, nuclear magnetic resonance/magnetic resonance imaging contrast agents, etc. Reveal the problems of low loading rate of ionic liquids and reduce treatment efficiency, and achieve the effect of perfecting cancer treatment effect, wide application range and strong penetrating power

Inactive Publication Date: 2017-09-22
SOUTHWEST UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Further applications of these new nanocomposites are still limited by the following reasons: low loading of ionic liquids by hollow nanoparticles, accidental leakage of ionic liquids in the composites can cause potential toxicity and reduce therapeutic efficiency, and nanoions as carriers of ionic liquids And the intrinsic physical and chemical properties in tumor therapy have not been revealed, etc.

Method used

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  • Copper, zinc, tin and sulfur quaternary nanocomposite with functions of microwave sensitization and nuclear magnetic imaging and preparation and application method thereof
  • Copper, zinc, tin and sulfur quaternary nanocomposite with functions of microwave sensitization and nuclear magnetic imaging and preparation and application method thereof
  • Copper, zinc, tin and sulfur quaternary nanocomposite with functions of microwave sensitization and nuclear magnetic imaging and preparation and application method thereof

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Experimental program
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Effect test

Embodiment 1

[0064] (1) Copper acetate aqueous solution with a concentration of 50mM, zinc acetate aqueous solution with a concentration of 30mM, and tin chloride aqueous solution with a concentration of 30mM are dissolved in 50mL of ethylene glycol, and stirred evenly to obtain precursor solution A;

[0065] (2) Dissolving an aqueous solution of sodium sulfide with a concentration of 10mM in 10mL of methanol to obtain a precursor solution B;

[0066] (3) After heating the precursor solution A to 180 °C, quickly inject the precursor solution B, and continue to react for 2 hours. After the reaction solution is cooled to room temperature, add ethanol for centrifugation, collect and dry the lower precipitate after centrifugation, and obtain the basic Nano copper zinc tin sulfur compound;

[0067] (4) Take polyethylene glycol with a molecular weight of 0.5 million and mix it with the above-mentioned basic nanometer copper-zinc-tin-sulfur compound, sonicate at a frequency of 40 kHz for 10 minut...

Embodiment 2

[0072] (1) Dissolve copper chloride (50mM), zinc chloride (30mM) and tin chloride (30mM) precursors in 50mL of ethylene glycol, stir well to obtain precursor solution A;

[0073] (2) Dissolve sodium sulfide (10mM) in 10mL of absolute ethanol to obtain precursor solution B;

[0074] (3) Heat the precursor solution A to 160 °C, quickly inject the precursor solution B, and continue the reaction for 1 hour. After the reaction solution is cooled to room temperature, add ethanol, centrifuge, collect the lower precipitate and dry it to obtain the basic nano-copper zinc tin sulfur compound;

[0075] (4) Take polyethylene glycol with a molecular weight of 0.3 million and mix it with the above-mentioned basic nanometer copper-zinc-tin-sulfur compound, sonicate at 30 kHz for 60 minutes, and then shake at room temperature for 8 hours at a frequency of 40 Time / min. The mass ratio to the basic nano-copper-zinc-tin-sulfur compound is 0.2:1, and after the shock is completed, it is centrifuge...

Embodiment 3

[0078] (1) Dissolve the precursors of cuprous chloride (50mM), zinc chloride (30mM), and tin nitrate (30mM) in 50mL of ethylene glycol, and stir well to obtain precursor solution A;

[0079] (2) Dissolve thiourea (10mM) in 10mL methanol to obtain precursor solution B;

[0080] (3) Heat the precursor solution A to 150 °C, quickly inject the precursor solution B, and continue to react for 3 hours. After the reaction solution is cooled to room temperature, add ethanol, centrifuge, collect the lower precipitate and dry it to obtain the basic nano-copper zinc tin sulfur compound;

[0081] (4) Take polyethylene glycol with a molecular weight of 100,000 and mix it with the above-mentioned basic nanometer copper-zinc-tin-sulfur compound, sonicate at 50 Hz for 80 minutes, and then vibrate at room temperature for 6 hours at a frequency of 60 Time / min. The mass ratio to the basic nano-copper-zinc-tin-sulfur compound is 0.5:1, and after the shaking is completed, it is centrifuged and was...

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Abstract

The invention discloses a copper, zinc, tin and sulfur quaternary nanocomposite with functions of microwave sensitization and nuclear magnetic imaging and a preparation and application method thereof. The copper, zinc, tin and sulfur quaternary nanocomposite with functions of microwave sensitization and nuclear magnetic imaging comprises nano copper, zinc, tin and sulfur compound and biocompatible molecules on the surface of the compound. By the copper, zinc, tin and sulfur quaternary nanocomposite with the functions of microwave sensitization and nuclear magnetic imaging, microwave hyperthermia and microwave induced photodynamic therapy can be combined together. The copper, zinc, tin and sulfur quaternary nanocomposite with functions of microwave sensitization and nuclear magnetic imaging has an excellent tumor treatment effect.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to the field of copper-zinc-tin-sulfur quaternary nanocomposite materials for biomedicine. Background technique [0002] The high morbidity and rising mortality of cancer seriously threaten the global public health security. Traditional cancer treatment methods such as surgery, chemotherapy, and radiotherapy will inevitably produce relatively large toxic and side effects on the human body, such as harming normal cells and tissues, and destroying the immune system. [0003] As a new type of treatment, phototherapy (photodynamic therapy) absorbs light energy through the photosensitizer in the patient's body, which is then excited to produce excessive active oxygen or generate high temperature, which reacts with cancer cells to make them die. Because of its instinctive selectivity and specificity, it can effectively avoid the occurrence of the above-mentioned problems in the tradit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61P35/00A61K49/06
CPCA61K41/0052A61K41/0057A61K49/06
Inventor 万静欧才彰
Owner SOUTHWEST UNIVERSITY FOR NATIONALITIES
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