A preparation of yeast cell wall particles that promotes the oral absorption of protein and polypeptide drugs

A yeast cell wall and drug technology, which is applied in drug combinations, peptide/protein components, medical preparations of non-active ingredients, etc., can solve problems such as unpredictable development prospects, large protein molecular weight, and inability to achieve therapeutic effects
CN107233298BActive Publication Date: 2021-01-22FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
FUDAN UNIV
Publication Date
2021-01-22

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Abstract

The invention belongs to the field of a medicine preparation, and particularly relates to a yeast cell wall microparticle preparation for promoting oral absorption of protein polypeptide medicine. Protein or polypeptide medicine is entrapped in yeast cell wall microparticles. The stability of the protein or polypeptide medicine in the gastrointestinal tract is further improved through the inside gelation; and the fast leakage degradation of the protein or the polypeptide medicine in the gastrointestinal tract is ensured to be avoided. The yeast cell wall microparticles can specifically target M cells of Peyer's Patches in the intestinal tract, and enters the lymphokinesis through M cell transportation to improve the oral administration bioavailability of protein polypeptide medicine. Through animal experiments, the result shows that the yeast cell wall microparticle preparation has the advantages that the oral administration bioavailability of insulin can be obviously improved; and the obvious application prospects are realized in the field of protein or polypeptide oral administration.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a preparation of yeast cell wall particles capable of promoting oral absorption of proteins or polypeptides and a preparation method thereof. Background technique

[0002] In recent years, more and more protein and peptide drugs have entered the clinical trial or clinical treatment stage. The main way of administration is injection. The compliance is extremely poor; therefore, the development of non-injection protein and polypeptide preparations has become a hot spot in the field of pharmacy research, and it is also a topic that needs key breakthroughs in related fields. Clinical practice shows that oral administration is the most convenient and safest way of clinical drug administration, but protein and peptide drugs have the following problems, resulting in low oral bioavailability and inability to achieve a good therapeutic effect: 1. In gastric juice Un...

Claims

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