Targeted nanoparticle carrier for carrying bladder cancer treating drug and preparation method and application thereof
A nanoparticle and cancer treatment technology, applied in the field of nanomaterial technology and biomedical materials, can solve the problems of low targeting and different amount of drug-carrying carriers, and achieve reduced dosage, precise killing, and high biocompatibility. Effect
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[0034] Example 1
[0035] Formulated to contain 2M FeCl 2 4H 2 O, 1M FeCl 3 6H 2 A mixed iron salt solution of O and 2M HCl, deoxygenate with nitrogen for 10 min. In N 2 Under conditions, the mixed iron salt solution was added dropwise to 250 mL of an oxygen-free ammonia aqueous solution with a concentration of 0.7 M, and stirred vigorously for 30 min at room temperature. Separate the magnet, wash with ultrapure water until it is neutral, put it in a 250mL volumetric flask with a constant volume, seal and store to obtain Fe 3 O 4 MNPs stock solution.
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[0036] Example 2
[0037] Formulated with 0.04M FeCl 3 ·6H 2 O and 20μL H with a mass fraction of 30% 2 O 2 40mL of mixed aqueous solution, marked as solution A; preparation containing 0.04M K 3 Fe(CN) 6 With 20μL of 30% H 2 O 2 40mL of mixed aqueous solution is recorded as solution B; while stirring, solution A is slowly added dropwise to solution B, and then 20mL Fe 3 O 4 MNPs stock solution, stirred for 3h, solution containing magnetic Prussian blue nanoparticles. Take out the colloidal solution, perform magnetic separation and cleaning, and dry the separated product in a vacuum drying box to obtain powdered PBMNPs.
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[0038] Example 3
[0039] Under magnetic stirring, add an aqueous solution of polyvinylpyrrolidone (PVP) with a concentration of 5 mg / mL to a polytetrafluoroethylene container containing a PBMNPs solution with a concentration of 1 mg / mL. After about 3 hours, the solution is heated in an electric furnace at 140°C. Place in a stainless steel autoclave for 4 hours. After the reaction is over, centrifugal separation is performed, and after centrifugation, the precipitate is washed several times in distilled water. After freeze-drying, hollow nanoparticle carriers (HPBMNPs) are obtained.
[0040] Use scanning electron microscope (SEM) and transmission electron microscope (TEM) to characterize PBMNPs and HPBMNPs such as figure 1 As shown, a is the SEM and PBMNPs; b and c are the SEM and TEM images of HPBMNPs, respectively. It can be seen that the particle size of the synthesized HPBMNPs is about 100nm, with a hollow of about 90nm, and the micropores therein are less than 2nm, which is ...
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