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Method used for continuous preparation of glycine from hydroxyacetonitrile

A technology of hydroxyacetonitrile and glycine, which is applied in chemical instruments and methods, cyanide reaction preparation, organic compound preparation, etc., can solve the problem that glycine cannot realize continuous production, and achieve the continuous production of the whole process, which is environmentally friendly, clean, and material mixing Fully and evenly heated effect

Active Publication Date: 2017-11-07
山西华阳集团新能股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The technical problem to be solved in the present invention is to provide a method for the continuous preparation of glycine from hydroxyacetonitrile for the problem that the preparation of glycine from hydroxyacetonitrile in the prior art cannot realize continuous production

Method used

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  • Method used for continuous preparation of glycine from hydroxyacetonitrile
  • Method used for continuous preparation of glycine from hydroxyacetonitrile
  • Method used for continuous preparation of glycine from hydroxyacetonitrile

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Embodiment 1

[0035] Embodiment 1: Continuous preparation of glycine with hydroxyacetonitrile

[0036] The raw materials are hydroxyacetonitrile, ammonium bicarbonate and water, and the three substances are mixed according to the molar ratio of 1:2:50, and transported by the metering pump to the tubular packing reactor at 350L / hour for the synthesis of hydantoin and the hydrolysis reaction of hydantoin. The temperature of the first stage of the tubular packing reactor is 90°C, the pressure is 7MPa, and the residence time is 15min; the temperature of the second stage is 130°C, the pressure is 7MPa, and the residence time is 15min; Afterwards, the feed liquid enters the tank-type series reactors to continue the hydantoin hydrolysis reaction. Reactor 1 has a temperature of 160°C, a pressure of 7MPa, and a residence time of 2 hours. Reactor 2 has a temperature of 180°C, a pressure of 7MPa, and a residence time of 1 hour. Reactor 3 The temperature is 200°C, the pressure is 7MPa, and the residenc...

Embodiment 2

[0037] Embodiment 2: Continuous preparation of glycine by hydroxyacetonitrile

[0038] The raw materials are hydroxyacetonitrile, ammonium bicarbonate and water, and the three substances are mixed according to the molar ratio of 1:2:50, and transported by the metering pump to the tubular packing reactor at 350L / hour for the synthesis of hydantoin and the hydrolysis reaction of hydantoin. The temperature of the first stage of the tubular packing reactor is 90°C, the pressure is 5MPa, and the residence time is 15min; the temperature of the second stage is 110°C, the pressure is 5MPa, and the residence time is 15min; 5MPa, residence time 15min. Afterwards, the feed liquid enters the tank-type series reactors to continue the hydantoin hydrolysis reaction. Reactor 1 has a temperature of 150°C, a pressure of 5MPa, and a residence time of 2 hours. Reactor 2 has a temperature of 170°C, a pressure of 5MPa, and a residence time of 1 hour. Reactor 3 The temperature is 190°C, the pressur...

Embodiment 3

[0039] Embodiment 3: Continuous preparation of glycine by hydroxyacetonitrile

[0040] The raw materials are hydroxyacetonitrile, ammonium bicarbonate and water, and the three substances are mixed according to the molar ratio of 1:2:50, and transported by the metering pump to the tubular packing reactor at 350L / hour for the synthesis of hydantoin and the hydrolysis reaction of hydantoin. No modified θ-ring packing was added to the tubular reactor. The temperature of the first stage of the tubular reactor is 90°C, the pressure is 8MPa, and the residence time is 15min; the temperature of the second stage is 130°C, the pressure is 8MPa, and the residence time is 15min; Afterwards, the feed liquid enters the tank-type series reactors to continue the hydantoin hydrolysis reaction. Reactor 1 has a temperature of 160°C, a pressure of 8MPa, and a residence time of 2 hours. Reactor 2 has a temperature of 180°C, a pressure of 8MPa, and a residence time of 1 hour. Reactor 3 The temperat...

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Abstract

The invention provides a method used for continuous preparation of glycine from hydroxyacetonitrile. According to the method, hydroxyacetonitrile, an ammonia source, and a carbon source are delivered into a device composed of a tubular packed reactor and a kettle-type tandem reactor for synthesis and hydrolysis reaction successively, and then high purity glycine is obtained via distillation, crystallization, separation, and drying. The kettle-type tandem reactor is composed of at least three hydrolysis reaction kettles connected in series via an overflow pipe. Compared with kettle-type batch process in the prior art, the method possesses following advantages: whole flow continuous production of glycine from hydroxyacetonitrile via hydantoin is realized, and no waste liquid is generated.

Description

technical field [0001] The invention relates to the field of fine chemicals, in particular to a method for continuously preparing glycine from hydroxyacetonitrile. Background technique [0002] Glycine, also known as aminoacetic acid, is the amino acid with the simplest structure. As an important fine chemical intermediate, it is widely used in the fields of pesticide, medicine, food, feed, daily chemical and electroplating. my country is the largest producer and consumer of glycine in the world, and the market size of glycine exceeds 350,000 tons. At present, the industrial production technologies of glycine mainly include the improved Streck method, the direct Hyne method and the ammonolysis method of chloroacetic acid. Due to the monopoly of foreign technology, the production of glycine in my country still uses the backward chloroacetic acid method. Compared with the improved Streck method and the direct Heine method, this method has disadvantages such as high production...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/08C07C227/24C07D233/74
CPCC07C227/24C07D233/74C07C229/08
Inventor 冯志武袁秋华龚文照张伟王向龙赵广贾晨李鑫
Owner 山西华阳集团新能股份有限公司
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