Starch-based microporous hemostatic material having antibacterial function, and preparation method and application of the material

A hemostatic material, starch-based technology, applied in pharmaceutical formulations, pharmaceutical science, absorbent pads, etc., to achieve high water absorption, good degradation performance, and good biocompatibility.

Active Publication Date: 2017-12-01
苏州佰济生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no reports of materials that combine the above properties

Method used

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  • Starch-based microporous hemostatic material having antibacterial function, and preparation method and application of the material
  • Starch-based microporous hemostatic material having antibacterial function, and preparation method and application of the material
  • Starch-based microporous hemostatic material having antibacterial function, and preparation method and application of the material

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0065] Preparation method of starch-based microporous hemostatic material

[0066] The preparation method of the starch-based microporous hemostatic material of the present invention includes the following steps:

[0067] (1) Preparation of microporous starch

[0068] Add starch and enzymes into phosphate buffer, stir at 40-80°C and pH 4-8, carry out enzymolysis reaction, 3-16 hours later, separate by suction filtration and dry to obtain microporous starch; ,

[0069] The mass ratio of starch and enzyme is 1: (0.01-0.3);

[0070] The mass-volume ratio of the total amount of starch and enzyme to the phosphate buffer is 100g: (150-1000) mL;

[0071] (2) Cationization of microporous starch

[0072] The microporous starch, cationic modifier, catalyst and water prepared in step (1) are mixed and stirred in a certain proportion, and the reaction is carried out for 4-30 hours with continuous stirring and heat preservation at 30-80℃. After centrifugal washing, the mixed solution is dried to obt...

Embodiment 1

[0110] (a) Preparation of microporous starch

[0111] Add 100g corn starch and 3g saccharification enzyme to 300mL pH=6 phosphate disodium hydrogen phosphate aqueous buffer solution, stir well, carry out enzymatic hydrolysis reaction at 45℃ for 8h, vacuum filter and wash, and freeze-dry Dry in the machine for 20 hours to obtain corn microporous starch.

[0112] (b) Cationization of microporous starch

[0113] Dissolve 10g of corn microporous starch in 45g of water, add 0.25g of potassium hydroxide and 3.0g of methylene dimethylamine hydrochloride, stir evenly, react at 50℃ for 20h, and proceed with a mixture of water and isopropanol Centrifugal washing, drying in a freeze dryer for 20 hours to obtain aminated corn microporous starch. The sample shape is like figure 1 Shown.

Embodiment 2～5

[0115] Examples 2 to 5 repeat the experimental steps of Example 1, except for some experimental conditions, as shown in Table 1-2.

[0116] Table 1 Preparation of microporous starch

[0117]

[0118] Table 2 Cationization of microporous starch

[0119]

[0120] Observe the microporous starches obtained in step (a) in Example 1 by scanning electron microscopes (see figure 2 (a) and 2(b)) and the amino-loaded microporous starch obtained in step (b) (see figure 2 (c) and 2(d)). It can be seen from the figure that the particle diameter of the microporous starch not loaded with amino groups is about 10-20 μm, the diameter of the pores is about 1-4 μm, and the micropores remain intact after the amino group modification.

[0121] The amino-loaded microporous starch prepared in Example 2-5 has a particle diameter of about 9-30 μm and a pore diameter of about 0.5-5 μm.

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Abstract

The invention discloses a starch-based microporous hemostatic material having antibacterial function, and a preparation method and an application of the material. The preparation method includes the steps of: preparing starch-based microporous starch; and supporting amino group ions on the microporous starch to finally produce the electro-positive starch-based microporous hemostatic material, which is 0.1-6 [mu]m in pore diameter, is 20-240 s in hemostatic time, reaches 50-100% in antibacterial rate and can be completely degraded in 4-240 h in vivo. The material can quickly and effective stop bleeding and also has antibacterial function, so that the material can prevent infection on a wound and accelerate healing of the wound without damage on normal cells. In the invention, starch, which has wide sources and low cost, is used as a raw material; the starch is subjected to micropore forming and then supports the amino group, thereby producing the hemostatic material having physical and chemical hemostatic mechanisms. The material can rapidly stop bleeding, has high stickiness and good biocompatibility, is quick to degrade in vivo, is wide in available range and has hemostatic and antibacterial functions at the same time.

Description

Technical field [0001] The invention belongs to the field of tissue damage repairing medical materials, and in particular relates to a starch-based microporous hemostatic material with antibacterial properties and a preparation method and application thereof. Background technique [0002] Bleeding is a phenomenon in which blood flows from blood vessels or the heart to interstitial spaces, body cavities or outside the body. It is more common in wars, traffic accidents, natural disasters, first aid and surgical operations. Bleeding is often accompanied by infection, and even endangers human life. Therefore, it is imperative to prepare a new type of rapid hemostatic material with superior performance. [0003] After hemostasis is completed, the wound surface is covered with residual material and exposed to the air for a long time. At this time, the bacteria in the air will be deposited on the surface of the material. In this way, the residual material of the wound becomes a carrier fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/28A61L15/64
CPCA61L15/28A61L15/425A61L15/64A61L2400/04C08L3/04
Inventor 刘昌胜陈芳萍曹晓艳
Owner 苏州佰济生物科技有限公司
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