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Thickening nutrition preparation for patients with dysphagia and preparation method thereof

A technology of enteral nutrition preparation and carboxymethyl cod gum, which is applied in the field of enteral nutrition preparations, can solve the problems that are not conducive to improving the nutrition supplement and enhancement of nutrition preparations, the viscosity and rheological properties of nutrition preparations cannot meet the requirements, and the It is suitable for patients with dysphagia to eat directly, to achieve the effect of good thickening effect, rich nutrition and immunity, and improve immunity

Active Publication Date: 2017-12-22
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the ordinary liquid oral nutritional preparations currently available on the market are not suitable for direct consumption by patients with dysphagia due to their low viscosity.
Thickened nutritional preparations are also used in other existing published documents, such as patent WO2009072885, patent CN103037874 and patent WO03055334, but each has many shortcomings, such as: (1) the protein source of nutritional preparations uses casein and casein Salts and other proteins with high energy density have defects such as casein allergy or indigestion, making them difficult to absorb; (2) The thickener is selected from protein, carrageenan, gum, starch or other combinations
Starch is used to thicken the beverage of patients with dysphagia. Since the human oral cavity contains salivary amylase, the starch in the bolus will be decomposed and cause a decrease in viscosity, which will change the viscoelasticity of the bolus; on the other hand, starch granules are easy to absorb water Swelling, its physical properties have great temperature dependence and time dependence, which will lead to a large difference between the fluid viscosity of starch-thickened food at different temperatures or different preparation times and the initial preparation viscosity, resulting in the actual nutrition obtained The viscosity and rheological properties of the formulation do not meet the requirements
(3) Thickeners used in existing nutritional preparations lack beneficial biological activity and are not dietary fiber, which is not conducive to improving the supplementation and enhancement of nutrition in nutritional preparations
[0008] According to the search of the prior art literature, there is no public report on the technology and formula of carboxymethyl cod gum and konjac gum compound as a thickener for nutritional preparations containing pea protein and rice protein.

Method used

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  • Thickening nutrition preparation for patients with dysphagia and preparation method thereof
  • Thickening nutrition preparation for patients with dysphagia and preparation method thereof
  • Thickening nutrition preparation for patients with dysphagia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Step 1: Weigh respectively carboxymethyl cod gum with a weight ratio of cod cod gum and konjac gum (CMCD:KGM) of 1:0, 3:1, 1:1, 1:3, 0:1, Konjac gum mixed solid powder is dissolved in deionized water, stirred at room temperature until completely dissolved, and formulated into 0.1% carboxymethyl cod gum and konjac gum composite aqueous solution;

[0071] Step 2: Weighing five parts of 12% maltodextrin, 4% pea protein, 4% soybean oil, trace minerals and vitamins in turn, respectively, and dissolving them in five parts of the compound aqueous solution obtained in step 1, stirring until Evenly dispersed;

[0072] Step 3: Disperse and homogenize with a high-speed dispersing homogenizer to obtain five uniformly dispersed liquid enteral nutritional preparations of the present invention in different proportions.

[0073] Use the Haake Mars-III rotational rheometer to test the liquid enteral nutrition formulation obtained in Example 1 and show that: the liquid enteral nutrition...

Embodiment 2

[0075] Step 1: Weigh the mixed solid powder of carboxymethyl cod gum and konjac gum with a weight ratio of 1:0, 3:1, 1:1, 1:3, 0:1 respectively Dissolve in deionized water, stir at room temperature until completely dissolved, and make five parts of 0.2% carboxymethyl cod gum and konjac gum compound aqueous solution;

[0076] Step 2: Weighing five parts of 12% maltodextrin, 4% pea protein, and 4% soybean oil in turn, respectively, and dissolving them in the five parts of the compound aqueous solution obtained in step 1, and stirring until uniformly dispersed;

[0077]Step 3: Disperse and homogenize with a high-speed dispersing homogenizer to obtain five uniformly dispersed liquid enteral nutritional preparations of the present invention in different proportions.

[0078] Use the Haake Mars-III rotational rheometer to test the liquid enteral nutrition formulation obtained in Example 2 and show that: the liquid enteral nutrition formulation of Example 2 is at 10S -1 The viscosit...

Embodiment 3

[0080] Step 1: Weigh the mixed solid powder of carboxymethyl cod gum and konjac gum with a weight ratio of 1:0, 3:1, 1:1, 1:3, 0:1 respectively Dissolve in deionized water, stir at room temperature until completely dissolved, and make five parts of 0.3% carboxymethyl cod gum and konjac gum compound aqueous solution;

[0081] Step 2: Weighing five parts of 12% maltodextrin, 4% pea protein, 4% soybean oil, trace minerals and vitamins in sequence, respectively, and dissolving them in five parts of the compound aqueous solution obtained in step 1, Stir until evenly dispersed;

[0082] Step 3: Disperse and homogenize with a high-speed dispersing homogenizer to obtain five uniformly dispersed liquid enteral nutritional preparations of the present invention in different proportions.

[0083] Use the Haake Mars-III rotational rheometer to test the liquid enteral nutrition formulation obtained in Example 3 and show that: the liquid enteral nutrition formulation of Example 3 is at 10S ...

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Abstract

The invention discloses a liquid enteral nutrition preparation that contains a low substitution degree carboxymethyl curdlan (also called carboxymethyl curdlan) and konjac gum compound as the thickening agent and has an energy density of 1-3kcal / ml. The nutrition preparation comprises the following components by weight percent: 0.1%-1% of the low substitution degree carboxymethyl curdlan and konjac gum compound, 4%-20% of protein, 4%-10% of fat, and 10%-20% of carbohydrate. The low substitution degree carboxymethyl curdlan and konjac gum are in a weight ratio of 1:0-0:1. The invention also provides a preparation of the liquid enteral nutrition preparation. The liquid enteral nutrition preparation containing the low substitution degree carboxymethyl curdlan and konjac gum compound as the thickening agent has appropriate initial viscosity, also has resistance to salivary amylase, is difficultly decomposable, has remarkable shear thinning rheological properties in the swallowing process, and has the advantages of delicate taste, no fishy smell, no allergic reaction, easy digestion and absorption, rich nutrition and immunity enhancement, and is suitable for diet nursing of patients with dysphagia.

Description

technical field [0001] The invention relates to the technical field of enteral nutritional preparations, in particular to a thickened nutritional preparation for patients with dysphagia. Background technique [0002] Dysphagia refers to the difficulty in swallowing and transporting solid or liquid food, saliva, drugs and other substances from the mouth to the stomach, and the patient will feel a sense of obstruction and stagnation in the pharynx, retrosternum or esophagus. Dysphagia can occur in people of all ages, and often occurs in the elderly, especially those suffering from neurodegenerative diseases and stroke. Dysphagia affects 60–80% of patients with neurodegenerative diseases and more than 30% of stroke patients. Other studies have shown that 22% of people over the age of 50, 10–30% of people over the age of 65, and 40% of people over the age of 70 suffer from swallowing disorders. It is conservatively estimated that at least 8% of the world's population has diffi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/00A23L29/244A23L29/20
CPCA23V2002/00A23L29/20A23L29/244A23L33/00A23V2200/30A23V2200/324A23V2200/32
Inventor 张洪斌位元元蔡志祥韦越孙小伟谢燕萍
Owner SHANGHAI JIAO TONG UNIV
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