High-strength-and-viscosity double-layer hydrogel and preparation method

A high-strength layer and hydrogel technology, which is applied in the field of physical cross-linking and viscous double-layer hydrogel, can solve the problems such as the lack of viscosity of tough hydrogel and the inability of functional hydrogel to meet market demands, and achieves good restorative effect

Inactive Publication Date: 2017-12-26
CHANGCHUN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the improvement of mechanical strength enables hydrogels to meet the requirements of some applications, the development of some functional hydrogels cannot meet market demand, especially in the development of viscous hydrogels, we found that stickiness and tough...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation of embodiment 1 composite bilayer hydrogel

[0029] Preparation of container A:

[0030] Measure 75.5g of deionized water into container A with mechanical stirring, and weigh 0.5g of sodium chloride into container A. After the sodium chloride is completely dissolved, continue to weigh 2g of dodecylsulfuric acid Sodium is put into container A. After the surfactant is completely dissolved, add 2g of hexyl methacrylate to the mixed solution in container A. After the solution in the container is transparent, take 20g of acrylamide and add it to the mixed solution. After the acrylamide was dissolved, 1 g of photoinitiator 2-hydroxy-4-(2-hydroxyethoxy)-2-methylpropiophenone was added.

[0031] Recipe in container B

[0032] Measure 70g of deionized water into container B with mechanical stirring, dissolve 15g of gum arabic in B, after the solid is dissolved, add 8g of gelatin, stir for 2 hours, add 6g of acrylamide into container B, After the medicine is co...

Embodiment 2

[0035] The preparation of embodiment 2 composite bilayer hydrogel

[0036] Preparation of container A:

[0037] Measure 75.5g of deionized water into container A with mechanical stirring, and weigh 0.5g of sodium chloride into container A. After the sodium chloride is completely dissolved, continue to weigh 1g of dodecylsulfuric acid Put the sodium into container A. After the sodium lauryl sulfate is completely dissolved, add 1g of lauryl methacrylate to the mixture in container A. After the solution in the container is transparent, take 22g of hyaluronic acid Add to the mixture, when the acrylamide is dissolved, add the photoinitiator 2-hydroxy-2-methyl-1-phenylmethanone (PI 1173).

[0038] Preparation of container B

[0039] Measure 70g of deionized water into container B with mechanical stirring, and put 20g of gum arabic into container B. After the drug is completely dissolved, add 5g of gelatin and 1g of photoinitiator 2-hydroxy- 2-Methyl-1-phenylmethanone (PI1173).

...

Embodiment 3

[0041] Use a pipette gun to take 5ml of the liquid in container A, put it into a special mold, add a photoinitiator, put it into a photoinitiator, adjust the light intensity to 50%, and after the light time is 10min, quickly put the liquid in container B Add 5ml of the solution to the formed gel, continue to illuminate for 20 minutes, and the light intensity is still 50%. After the illumination is over, take out the sample and adjust the pH of the viscous layer to 4.0-6.0. Preparation is complete. The preparation of embodiment 3 composite bilayer hydrogel

[0042] Container A Recipe

[0043] Measure 70g of deionized water and put it into container A with mechanical stirring, continue to weigh 7g of sodium dodecylbenzenesulfonate and put it into container A, after the sodium dodecylbenzenesulfonate is completely dissolved, put Add 2g of lauryl methacrylate to the mixed solution in container A. After the solution in the container is transparent, take 19g of acrylamide and add ...

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PUM

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Abstract

The invention relates to high-strength-and-viscosity double-layer hydrogel and a preparation method thereof. The preparation method comprises the steps of forming a substrate layer by free radical polymerization, forming tough hydrogel, when free radical reaction is not completed, adding viscous hydrogel on a tough layer, and continuously performing free radical reaction, so that the upper-layer viscous hydrogel and the lower-layer tough hydrogel which is not completely reacted are bonded to form the high-strength-and-viscosity double-layer hydrogel. The method is proved to enable the hydrogel to have a good bonding property without an obvious layered structure; the method is simple and effective, toughness and viscosity are combined together, and the application field of the hydrogel is widened; shown by mechanical property tests, the mechanical strength of the viscous and tough hydrogel reaches 1.3 MPa, and release force strength can meet most application requirements.

Description

technical field [0001] The present invention relates to a physically cross-linked and viscous bilayer hydrogel. Background technique [0002] Hydrogel is a polymer material with a network crosslinked structure synthesized from hydrophilic monomers as the main monomer, which can absorb a large amount of water. Hydrogels are soft, similar to living tissue materials, and have good biocompatibility, so they are widely used in biomedicine, tissue engineering and other fields, such as tissue fillers, drug slow-release agents, enzyme embedding, Protein electrophoresis, contact lenses, artificial plasma, artificial skin, tissue engineering scaffold materials, etc. Most of the existing studies mainly focus on the properties of hydrogels such as toughness and biocompatibility, and there are not many studies on viscous hydrogels. In our country, the research work on hydrogel started late, and there are few manufacturers. The technical level and application level of hydrogel materials...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08F220/56C08F220/18C08F291/12C08F251/00C08F220/06
CPCC08F220/56C08F251/00C08F289/00C08J3/075C08J2489/00C08J2451/02C08J2405/00C08J2333/26C08J2351/02C08F220/1812C08F220/1806
Inventor 高光辉李斯良任秀艳
Owner CHANGCHUN UNIV OF TECH
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