Polycaprolactone/collagen/quaternary ammonium salt electrospun composite fiber membrane and method for preparing same

Abstract

The invention relates to a polycaprolactone / collagen / quaternary ammonium salt electrospun composite fiber membrane and a method for preparing the same, and belongs to the field of medical apparatus and instruments. The method includes regulating the mass and concentration ratios of polycaprolactone to collagen, evaluating the morphology of spun fibers and determining that the optimal proportion of the polycaprolactone to the collagen is 60-40 and the optimal concentration is 6%; adding quaternary ammonium salt with the concentration of 3% into the polycaprolactone and the collagen and carrying out electrospinning techniques to obtain the polycaprolactone / collagen / quaternary ammonium salt electrospun composite fiber membrane. The polycaprolactone / collagen / quaternary ammonium salt electrospun composite fiber membrane and the method have the advantages that the polycaprolactone / collagen / quaternary ammonium salt electrospun composite fiber membrane is easy and convenient to prepare and excellent in flexibility and mechanical property, and bleeding can be quickly stopped by the aid of the polycaprolactone / collagen / quaternary ammonium salt electrospun composite fiber membrane; a layer of protective fiber felt can be formed on the surface of wound by the polycaprolactone / collagen / quaternary ammonium salt electrospun composite fiber membrane, wound repair can be promoted, bacterial infection can be prevented, accordingly, skin injury can be cured, the polycaprolactone / collagen / quaternary ammonium salt electrospun composite fiber membrane has bleeding stopping, antibacterial, anti-inflammation and trauma repair functions and the like and is quite suitable to be used as a bleeding stopping, trauma repair and medical instrument material, and the polycaprolactone / collagen / quaternary ammonium salt electrospun composite fiber membrane and the method have excellent application prospects.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a composite fiber membrane with functions of hemostasis, antibacterial and anti-inflammation, and wound repair and a preparation method thereof. Background technique [0002] Bleeding is the main complication of trauma and postoperative surgery. If there is too much bleeding or the bleeding cannot be effectively stopped, shock will be caused, and in severe cases, life-threatening. Therefore, timely and effective hemostasis is of great significance to reduce the suffering of patients and save their lives. At present, many domestic and international well-known large pharmaceutical companies are committed to the research and development of new hemostatic materials, and a variety of hemostatic materials with different compositions and mechanisms have been applied clinically. Such as α-cyanoacrylate tissue glue, carboxymethylcellulose soluble hemostatic gauze, fibrin glue, c...

AI Technical Summary

Problems solved by technology

However, if collagen and quaternary ammonium salts are directly electrospun into fibrous membranes, the mechanical properties of the membranes are poor. Therefore, it is necessary to co-spin collagen, quaternary ammonium salts and other materials (such as polycaprolactone) to Increase the tensile strength of the electrospun fiber membrane, improve its mechanical properties, and control the degradation time

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