Controlled preparation method of surface porous structure of polylactic acid/HAP (hydroxyapatite) composite microspheres and application

A technology of hydroxyapatite and composite microspheres, which is applied in medical preparations of non-active ingredients, pharmaceutical formulas, medical science, etc., can solve the problems of many variables to be controlled, difficulties in process amplification, and residues of pore-forming agents, etc., to achieve Easy regulation, simple preparation process and high dispersion uniformity

Active Publication Date: 2017-12-29
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main disadvantage of the double emulsion method is that the process is more complicated, there are many variables to be controlled, and it is difficult to scale up the process.
The main pore-forming agent used in the pore-forming agent method is ammonium bicarbonate, and a small amount of acetic acid solution needs to be added during the preparation process. This method is prone to residues of pore-forming agents and the introduction of substances outside the microsphere system.

Method used

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  • Controlled preparation method of surface porous structure of polylactic acid/HAP (hydroxyapatite) composite microspheres and application
  • Controlled preparation method of surface porous structure of polylactic acid/HAP (hydroxyapatite) composite microspheres and application
  • Controlled preparation method of surface porous structure of polylactic acid/HAP (hydroxyapatite) composite microspheres and application

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Experimental program
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Effect test

Embodiment 1

[0025] First, the precipitation method was used to prepare nano-HAP at 37 °C, and the Ca 2+ Calcium nitrate aqueous solution and PO with a concentration of 0.0334mol / L 4 3- Diammonium hydrogen phosphate aqueous solution with a concentration of 0.02mol / L, and then according to the Ca / P molar ratio of 1.67 stoichiometric ratio, heat and stir the prepared solution on a constant temperature magnetic stirrer at 37°C, and rapidly diammonium hydrogen phosphate aqueous solution Pour into the calcium nitrate aqueous solution, stir vigorously and mix evenly, after mixing evenly, add concentrated ammonia water dropwise to the solution, control the pH of the solution in the range of 10-11, react at 37°C for 1 hour, centrifuge the milky white turbid liquid, and deionized water Rinse three times to obtain a white precipitate, which is stored in a refrigerator for freezing. After the white precipitate is frozen, it is dried in a freeze dryer and taken out for later use. After testing, the ...

Embodiment 2

[0029] First, nano-HAP was prepared at 60 °C by precipitation method. Separately prepare Ca 2+ Calcium nitrate aqueous solution and PO with a concentration of 0.0334mol / L 4 3-Diammonium hydrogen phosphate aqueous solution with a concentration of 0.02mol / L, and then according to the Ca / P molar ratio of 1.67 stoichiometric ratio, heat and stir the prepared solution on a constant temperature magnetic stirrer at 60°C, and rapidly diammonium hydrogen phosphate aqueous solution Pour into calcium nitrate aqueous solution, stir vigorously and mix evenly, add concentrated ammonia water dropwise to the solution after mixing evenly, control the pH of the solution in the range of 10-11, react at 60°C for 1 hour, centrifuge the milky white turbid liquid, and deionized water Rinse three times to obtain a white precipitate, which is stored in a refrigerator for freezing. After the white precipitate is frozen, it is dried in a freeze dryer and taken out for later use. After testing, the av...

Embodiment 3

[0033] First, nano-HAP was prepared by precipitation method at 80 °C. Separately prepare Ca 2+ Calcium nitrate aqueous solution and PO with a concentration of 0.0334mol / L 4 3- Diammonium hydrogen phosphate aqueous solution with a concentration of 0.02mol / L, and then according to the Ca / P molar ratio of 1.67 stoichiometric ratio, heat and stir the prepared solution on a constant temperature magnetic stirrer at 80°C, and rapidly diammonium hydrogen phosphate aqueous solution Pour into calcium nitrate aqueous solution, stir vigorously and mix evenly, add concentrated ammonia water dropwise to the solution after mixing evenly, control the pH of the solution in the range of 10-11, react at 80°C for 1 hour, centrifuge the milky white turbid solution, and deionized water Rinse three times to obtain a white precipitate, which is stored in a refrigerator for freezing. After the white precipitate is frozen, it is dried in a freeze dryer and taken out for later use. After testing, the...

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Abstract

The invention discloses a controlled preparation method of the surface porous structure of polylactic acid / HAP (hydroxyapatite) composite microspheres and application. The method is characterized in that HAP and polylactic acid are used as raw materials; the controlled preparation of the surface porous structure of the polylactic acid / HAP composite microspheres is realized by regulating and controlling the size of the HAP on the basis of an emulsion solvent volatilization method. By the method, the additional addition of pore-forming agents is not needed; the self ingredients of the composite microspheres are used for pore formation; the surface hole structure of the prepared microspheres is easy to control. The porous polylactic acid / HAP composite microspheres can be used for additive manufacturing of selective laser sintering and for preparing bone defect repair materials and can also be used as a medicine release carrier for disease treatment.

Description

technical field [0001] The invention belongs to the technical field of functional composite materials, and in particular relates to a controllable preparation method for the surface porous structure of polylactic acid / hydroxyapatite composite microspheres. The composite microsphere can be used as a raw material for selective laser sintering (SLS) additive manufacturing, for preparing bone defect repair materials, and can also be used as a drug release carrier for disease treatment. Background technique [0002] Bone defects caused by accidents and diseases are common clinical orthopedic diseases, and the clinical demand for bone defect repair materials is growing rapidly. Polylactic acid (PLA) has good biocompatibility and biodegradability, and has been widely used clinically, but its degradation products are acidic, which can easily cause a decrease in the local pH value in the body, resulting in an aseptic inflammatory reaction in the body, which is not conducive to bone ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/56A61L27/58A61K47/34A61K47/02A61K47/69
CPCA61K47/02A61K47/34A61L27/46A61L27/56A61L27/58A61L2400/12A61L2430/02C08L67/04
Inventor 韩颖超颜冬戴红莲
Owner WUHAN UNIV OF TECH
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