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Method for preparing hydroxyapatite coating on surface of aluminium oxide

A technology of hydroxyapatite and alumina, applied in coatings, medical science, prostheses, etc., can solve the problems of difficult precise control of process conditions, inability to combine HA coatings, poor long-term implantation stability, etc., and achieve crystallinity Good, good stability, the effect of preventing falling off and failure

Inactive Publication Date: 2018-01-05
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

But Al 2 o 3 There are still some problems in the preparation of HA coatings on the surface of materials, such as Al 2 o 3 The HA coating prepared on the surface of the material has low bonding strength to the substrate, poor long-term implantation stability, coating peeling failure, uneven coating, and uncontrollable morphology and structure.
There are two main reasons for these problems, one is Al 2 o 3 The surface structure of the substrate is relatively smooth, which cannot effectively combine with the coated HA coating, resulting in low bonding strength
On the other hand, due to the many preparation methods of HA coatings, it is difficult to accurately control the process conditions of different preparation methods, which seriously affects the coating effect and morphology of HA coatings on the substrate, and the temperature of hydrothermal reaction and time are easy to control, the concentration and pH of the solution are easy to control

Method used

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  • Method for preparing hydroxyapatite coating on surface of aluminium oxide
  • Method for preparing hydroxyapatite coating on surface of aluminium oxide
  • Method for preparing hydroxyapatite coating on surface of aluminium oxide

Examples

Experimental program
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Effect test

Embodiment 1

[0040] Embodiment 1, a method for preparing a hydroxyapatite coating on the surface of alumina comprises the following steps:

[0041] Step 1, pre-treatment of the aluminum substrate: first, ultrasonically clean the aluminum substrate with a size of 1mm×1mm×0.5mm in acetone for 20 minutes to remove the grease on its surface, and then put it in 0.5mol / L NaOH solution at 80°C for 5 minutes. Remove the natural oxide film on the surface, wash the aluminum substrate with distilled water after the treatment, and finally, in order to ensure the smooth and bright surface of the aluminum substrate, use H 3 PO 4 (85%), H 2 SO 4 (98%), HNO 3 (68%) mixed acid to chemically polish the aluminum substrate, the volume ratio of the above three solutions is 7:2:1, the polishing temperature is 100°C, and the polishing time is 5min. After polishing, the aluminum substrate is ultrasonically cleaned with distilled water 3 times, the frequency of ultrasonic cleaning is 60-80KHz, the power is 60-...

Embodiment 2

[0044] Embodiment 2, a method for preparing a hydroxyapatite coating on the surface of alumina comprises the following steps:

[0045] Step 1: Pre-treatment of the aluminum substrate: First, ultrasonically clean the aluminum substrate with a size of 1mm×1mm×0.5mm in acetone for 20 minutes to remove the grease on its surface, and then put it in 0.8mol / L NaOH solution for 5 minutes at 80°C. Remove the natural oxide film on the surface, wash the aluminum substrate with distilled water after the treatment, and finally, in order to ensure the smooth and bright surface of the aluminum substrate, use H 3 PO 4 (85%), H 2 SO 4 (98%), HNO 3 (68%) mixed acid to chemically polish the aluminum substrate, the volume ratio of the above three solutions is 7:2:1, the polishing temperature is 100°C, and the polishing time is 5min. After polishing, the aluminum substrate is ultrasonically cleaned with distilled water 3 times, the frequency of ultrasonic cleaning is 60-80KHz, the power is 60-...

Embodiment 3

[0048] Embodiment 3, a method for preparing a hydroxyapatite coating on the surface of alumina comprises the following steps:

[0049] Step 1: Pre-treatment of the aluminum substrate: First, ultrasonically clean the aluminum substrate with a size of 1mm×1mm×0.5mm in acetone for 20 minutes to remove the grease on the surface, and then put it in 1mol / L NaOH solution at 80°C for 5 minutes to remove For the natural oxide film on the surface, wash the aluminum substrate with distilled water after the treatment, and finally, in order to ensure the smooth and bright surface of the aluminum substrate, use H 3 PO 4 (85%), H 2 SO 4 (98%), HNO 3 (68%) mixed acid to chemically polish the aluminum substrate, the volume ratio of the above three solutions is 7:2:1, the polishing temperature is 100°C, and the polishing time is 5min. After polishing, the aluminum substrate is ultrasonically cleaned with distilled water 3 times, the frequency of ultrasonic cleaning is 60-80KHz, the power is...

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Abstract

The invention discloses a method for preparing a hydroxyapatite coating on the surface of aluminium oxide. The method comprises the following steps: preparing a porous Al2O3 material through an anodicoxidation method at first; and then preparing an HA coating which is embedded, uniform and compact in epitaxial growth and controllable in morphology and structure on the porous Al2O3 matrix througha hydrothermal synthesis method. Because the surface of the Al2O3 material matrix is in a porous shape, the effective bonding with the HA coating, of the Al2O3 material matrix, is improved, and therefore, the HA coating prepared by the method disclosed by the invention is high in the strength of bonding with the matrix, high in long-time embedding stability, and capable of preventing the coating from falling off to be failed; and meanwhile, the HA coating prepared through the hydrothermal method is high in crystallinity, uniform and compact, controllable in morphology and structure, of a nanorod-shaped structure, simple in preparation process, simple to operate, easily available in raw materials, and low in preparation cost.

Description

technical field [0001] The invention belongs to the technical field of preparation of biological coatings on the surface of biomedical materials, and in particular relates to a method for preparing hydroxyapatite coatings on the surface of alumina. Background technique [0002] Thanks Al 2 o 3 With good mechanical strength, high temperature resistance, chemical corrosion resistance and good biocompatibility, it has been widely used as structural ceramics and functional ceramic materials, and is also the earliest modern ceramic material used in biomedical engineering. It is an ideal biomedical One of the implant materials, it has been widely used in the manufacture of artificial joints, artificial bones, artificial tooth roots, etc. [0003] But Al 2 o 3 The biological activity of the surface is insufficient, and after being implanted into the human body, it can only form a mechanical lock with the human bone, and the stability is not high. While hydroxyapatite (Ca 10 (...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D11/12C25D11/16C23C18/12A61L27/04A61L27/56A61L27/32
Inventor 赵雪妮张伟刚杨建军何富珍张黎王瑶刘庆瑶孙秀丽
Owner SHAANXI UNIV OF SCI & TECH
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