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Flexible glucose electrochemical transducer based on dendritic nano silver structure

A sensor and nano-silver technology, applied in the direction of electrochemical variables of materials, etc., can solve the problems of complex process, high production cost and low scale, and achieve the effects of excellent electrical conductivity, good mass production and simple preparation process.

Inactive Publication Date: 2018-01-05
DALIAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the cost of sensor materials made by these methods is high, the process is complicated, and the degree of scale is low, which makes the production cost of such products high and expensive, which restricts the popularization and application of CGMS systems.
[0004] At present, the industrial blood glucose meter adopts the method of laboratory measurement after acupuncture blood collection. Although this measurement method is more accurate, it will cause some pain to the patient, and this method is intermittent to the measurement of blood sugar. The data can only provide the concentration of blood sugar at the time of measurement, and cannot give accurate guidance on the dosage of insulin each time
It is very important to continuously measure the concentration of glucose in the body. The current glucose sensor cannot be applied to the clinic. Continuously measuring the concentration of glucose in the system is one of the problems that researchers are currently facing. One of the main reasons is its rigidity. The structure makes the biocompatibility of the glucose sensor poor, so it is of great significance to construct a flexible electrochemical biosensor for glucose

Method used

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  • Flexible glucose electrochemical transducer based on dendritic nano silver structure
  • Flexible glucose electrochemical transducer based on dendritic nano silver structure
  • Flexible glucose electrochemical transducer based on dendritic nano silver structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The ITO glass is self-assembled in 6 layers, and the ITO glass needs to be cleaned before assembly. The cleaning process is to ultrasonically clean the ITO glass with deionized water, acetone and ethanol for 30 minutes, respectively. After cleaning, put it into an ozone cleaner for surface hydroxylation. Then the ITO glass was self-assembled layer by layer in PDDA (polydiallyl dimethyl ammonium chloride) and PSS (polystyrene sodium sulfonate) solutions.

[0026] Deposit dendritic nano-silver on the assembled ITO glass, the method adopted is chronoamperometry, the reference electrode is a saturated mercurous sulfate electrode, the counter electrode is a platinum wire, the working electrode is an assembled ITO glass, and the electrolyte is AgNO 3 and NaNO 3 Mixed solution, deposition time 400s, AgNO 3 The concentration is 0.008mol / L, NaNO 3 The concentration is 0.1mol / L, and the set potential is -0.3V. Through electrochemical deposition, a white nano-silver conducti...

Embodiment 2

[0029] 6-layer self-assembly of ITO glass. ITO glass needs to be cleaned before assembly. The cleaning process is to ultrasonically clean the ITO glass with deionized water, acetone and ethanol for 30 minutes, respectively. After cleaning, put it into an ozone cleaner for surface hydroxylation. Then the ITO glass was self-assembled layer by layer in PDDA and PSS solution.

[0030] Deposit dendritic nano-silver on the assembled ITO glass, the method adopted is chronoamperometry, the reference electrode is a saturated mercurous sulfate electrode, the counter electrode is a platinum wire, the working electrode is an assembled ITO glass, and the electrolyte is AgNO 3 and NaNO 3 Mixed solution, deposition time 700s, AgNO 3 The concentration is 0.008mol / L, NaNO 3 The concentration is 0.1mol / L, and the set potential is -0.3V.

[0031] Put the silver-deposited ITO glass into the PDMS solution and put it into an oven for curing. The curing temperature is 70° C. and the curing ti...

Embodiment 3

[0033] 6-layer self-assembly of ITO glass. ITO glass needs to be cleaned before assembly. The cleaning process is to ultrasonically clean the ITO glass with deionized water, acetone and ethanol for 30 minutes, respectively. After cleaning, put it into an ozone cleaner for surface hydroxylation. Then the ITO glass was self-assembled layer by layer in PDDA and PSS solution.

[0034] Deposit dendritic nano-silver on the assembled ITO glass, the method adopted is chronoamperometry, the reference electrode is a saturated mercurous sulfate electrode, the counter electrode is a platinum wire, the working electrode is the previously assembled ITO glass, and the electrolyte is AgNO 3 and NaNO 3 Mixed solution, deposition time 800s, AgNO 3 The concentration is 0.008mol / L, NaNO 3 The concentration is 0.1mol / L, and the set potential is -0.3V.

[0035] Put the silver-deposited ITO glass into the PDMS solution and put it into an oven for curing. The curing temperature is 70° C. and the...

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Abstract

The invention discloses a flexible glucose electrochemical transducer based on a dendritic nano silver structure, and belongs to the technical field of electrochemical transducers. The base of a flexible electrode is PDMS, and a nano silver conducting layer of a dendritic structure is arranged on the PDMS base. The preparing method comprises the steps of self-assembling ITO glass, electrochemically depositing a nano argentea conducting layer of the dendritic structure on the ITO glass, putting the ITO glass with the nano silver conducting layer into a PDMS solution to be solidified, and uncovering the PDMS film from the ITO glass after solidifying to obtain the flexible glucose electrochemical transducer based on the dendritic nano silver structure. The flexible glucose electrochemical transducer responds well to glucose, is simple in preparing method, quantification production is easy to carry out, and the transducer is expected to be widely applied to the field of industrial engineering, the field of agricultural production, the field of life science research, and particularly the field of wearable medical facilities.

Description

technical field [0001] The invention relates to the field of electrochemical sensors, in particular to a flexible glucose electrochemical sensor based on a dendritic nano-silver structure. Background technique [0002] Glucose is the most important substance in living organisms. Glucose metabolism is the most basic energy conversion pathway in organisms and the cornerstone of normal metabolism, growth and development of organisms. Glucose metabolism in animals will be affected by blood sugar concentration and insulin content. When blood sugar concentration is too high or insulin is lacking in the body, glucose metabolism disorder will occur and cause diabetes. Wide fluctuations in blood sugar lead to chronic complications of diabetes such as blindness, kidney failure, heart attack and stroke. Therefore, the monitoring of blood sugar has vital significance for evaluating people's health status. [0003] At present, the methods for detecting glucose at home and abroad mainl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/48G01N27/36
CPCG01N27/36G01N27/48
Inventor 孙晶李秀平郎明非王迪周文慧罗才辉罗来福
Owner DALIAN UNIV
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