Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A figwort root processing method

A technology of Scrophulariaceae and ginseng medicinal materials, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, plant raw materials, etc., can solve the problems of structural changes of active ingredients, chemical structure changes, loss of pharmacological activity, etc., and achieve cardiac contractility enhancement , The processing method is simple, the effect of slowing down the heart rate

Inactive Publication Date: 2018-01-09
TIANSHENG PHARMA GROUP
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since cinnamic acid, harpagoside, harpagoside and other ingredients contain a large number of hydroxyl groups and carbon-carbon double bonds, conventional processing methods can easily cause loss of ingredients or changes in chemical structure, such as in the presence of oxidants, reducing agents, alcohols, acids and other substances It is very easy to undergo chemical reactions under conditions that cause structural changes in active ingredients, thereby losing pharmacological activity and even increasing toxicity

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A figwort root processing method
  • A figwort root processing method
  • A figwort root processing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The contents of cinnamic acid, harpagoside and harpagoside in Radix Scrophulariae were determined by HPLC.

[0037] Preparation of the test article

[0038] Take about 0.5g of Scrophulariaceae herb powder (passed through No. 3 sieve), accurately weigh it, put it in a stoppered Erlenmeyer flask, add 20mL of 80% methanol precisely, seal it tightly, weigh it, soak for 1 hour, and ultrasonically treat it for 60 minutes. Let it cool, then weigh it again, make up the lost weight with 80% methanol, shake well, filter, and take the filtrate to obtain the final product.

[0039] Preparation of reference solution or internal standard solution

[0040] Precisely weigh the appropriate amount of harpagoside reference substance, cinnamic acid reference substance and harpagoside reference substance dried with phosphorus pentoxide for 10 hours, add 30% methanol to dissolve and dilute to the mark, shake well, and use as reference substance stock solution for later use. Accurately abso...

Embodiment 2

[0049] Weigh 130g of Radix Scrophulariae medicinal material, put it in a beaker, measure 1000mL of distilled water into the beaker, seal it, soak for 24h, the difference of distilled water volume change is the index to investigate the maximum water absorption of Radix Scrophulariae Radix Scrophulariae medicinal material within 24h. Results After infiltration of Scrophulariaceae for 24 hours, the remaining volume of distilled water was 868mL, and the volume change was 132mL. The maximum water absorption capacity of Scrophulariae Radix Scrophulariae within 24 hours is 1mL per 1g of medicinal material.

Embodiment 3

[0051] On the basis of the water absorption test of Scrophulariaceae, take a proper amount of Scrophulariaceae, and measure distilled water equivalent to 1, 0.8, 0.6, 0.4, and 0.2 times (v / m) of the mass of the medicinal material, soak for 24 hours, cut into thin slices, and store at 50°C Dry for 48 hours. The detection method of Example 1 and the external standard method were used to determine the content, and the percentage content change of the total amount of harpagoside and harpagoside before and after processing was used as the main evaluation index to investigate the influence of the amount of water added on the processing technology of Scrophulariaceae scrophulariae. The results are shown in Table 1.

[0052] Table 1 Determination results of processed products of Scrophulariaceae with different amounts of water (n=3)

[0053]

[0054] As can be seen from the data in Table 1, the total content changes of harpagoside and harpagoside before and after processing are re...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A figwort root method is provided. Through effective control of a series of parameters, such as water adding amount, infiltration time and drying temperature, cinnamic acid, harpagide, harpagoside andother effective components in the processed figwort root are high in content. Compared with unprocessed figwort root, peak areas of the second and the third peaks in ten common characteristic peaks in fingerprint are reduced, peak areas of other peaks are all increased, and areas of the fifth peak, an S (cinnamic acid) peak, the seventh peak, the eighth peak and the tenth peak are obviously increased. Complex chemical components in a traditional Chinese medicine are compound bases of multiple effects of the traditional Chinese medicine. Through specific chromatograms before and after figwortroot processing, a plurality of components are changed during figwort root processing. The method is simple and suitable for large-scale production.

Description

technical field [0001] The invention relates to traditional Chinese medicine Scrophulariae, in particular to a processing method of Scrophulariae. technical background [0002] Scrophulariaceae is a herbaceous plant of the family Scrophulariaceae. It grows in bamboo forests, streams, jungles and tall grasses below 1,700 meters above sea level. It tastes sweet, bitter, salty, and slightly cold in nature. The effect of dissolving knots. Studies have shown that Scrophulariaceae is rich in cinnamic acid, harpagoside and harpagoside. Cinnamic acid, also known as β-phenylacrylic acid, 3-phenyl-2-acrylic acid, can be used to synthesize lactic acid Kexinding and Xintongping, important drugs for the treatment of coronary heart disease, and to synthesize chlorphenamine and cinnamon phenylpiperazine; It also has the effect of inhibiting the formation of tyrosinase, has a certain isolation effect on ultraviolet rays, can make brown spots lighter, and even disappears. It has significan...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/808G01N30/02A61K125/00
Inventor 刘群吴统选杨荣平谈宗华周文杰胡华东
Owner TIANSHENG PHARMA GROUP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com