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Hemostatic polypropylene non-woven fabric and preparation method thereof

A technology of polypropylene non-woven fabrics and non-woven fabrics, applied in the field of material chemistry, can solve the problems of uneven fiber diameter, unstable drug release, uneven drug loading, etc., and achieve the effect of uniform pore size and good sustained release performance

Inactive Publication Date: 2018-01-16
苏州市苏真床垫有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drug release of the above non-woven fabrics is unstable in the in vitro environment with different pH values, and the fiber diameter is not uniform, resulting in uneven drug loading.

Method used

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  • Hemostatic polypropylene non-woven fabric and preparation method thereof

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Comparison scheme
Effect test

Embodiment 1

[0024] A kind of hemostatic polypropylene non-woven fabric, by weight, described non-woven fabric comprises 26 parts of polypropylene non-woven fabrics, 16 parts of chitosan, 13 parts of polyvinyl alcohol, 12 parts of levofloxacin, 12 parts of acetic acid, sodium carbonate 8 parts, 12 parts of sodium styrene sulfonate, 2 parts of N-vinyl-2-pyrrolidone, 3 parts of acrylamide, 1 part of acrylic acid, 23 parts of deionized water.

[0025] A preparation method of hemostatic polypropylene non-woven fabric, said method comprising the following steps:

[0026] (1) Cut the polypropylene non-woven fabric into a 10cm×10cm sample, wash it with absolute ethanol, dry it at 18°C, wrap it around a glass rod into a cylindrical shape, and tie it up;

[0027] (2) Dissolve sodium styrene sulfonate, N-vinyl-2-pyrrolidone, and acrylamide in deionized water at 18°C, add acrylic acid dropwise to it, mix well and store in a sealed container at 4°C;

[0028] (3) Submerge the polypropylene non-woven f...

Embodiment 2

[0033] A kind of hemostatic polypropylene non-woven fabric, by weight, described non-woven fabric comprises 45 parts of polypropylene non-woven fabrics, 22 parts of chitosan, 23 parts of polyvinyl alcohol, 20 parts of levofloxacin, 16 parts of acetic acid, sodium carbonate 18 parts, 15 parts of sodium styrene sulfonate, 5 parts of N-vinyl-2-pyrrolidone, 6 parts of acrylamide, 6 parts of acrylic acid, 42 parts of deionized water.

[0034] A preparation method of hemostatic polypropylene non-woven fabric, said method comprising the following steps:

[0035] (1) Cut the polypropylene non-woven fabric into a 10cm×10cm sample, wash it with absolute ethanol, dry it at 28°C, roll it into a cylinder around the glass rod, and tie it up;

[0036] (2) Dissolve sodium styrene sulfonate, N-vinyl-2-pyrrolidone, and acrylamide in deionized water at 28°C, add acrylic acid dropwise to it, mix well and store in a sealed container at 4°C;

[0037] (3) Submerge the polypropylene non-woven fabric...

Embodiment 3

[0042] A kind of hemostatic polypropylene non-woven fabric, by weight, described non-woven fabric comprises 50 parts of polypropylene non-woven fabrics, 25 parts of chitosan, 28 parts of polyvinyl alcohol, 25 parts of levofloxacin, 19 parts of acetic acid, sodium carbonate 22 parts, 18 parts of sodium styrene sulfonate, 7 parts of N-vinyl-2-pyrrolidone, 8 parts of acrylamide, 8 parts of acrylic acid, and 48 parts of deionized water.

[0043] A preparation method of hemostatic polypropylene non-woven fabric, said method comprising the following steps:

[0044](1) Cut the polypropylene non-woven fabric into a 10cm×10cm sample, wash it with absolute ethanol, dry it at 35°C, roll it into a cylinder around the glass rod, and tie it up;

[0045] (2) Dissolve sodium styrene sulfonate, N-vinyl-2-pyrrolidone, and acrylamide in deionized water at 35°C, add acrylic acid dropwise to it, mix well and store in a sealed container at 4°C;

[0046] (3) Submerge the polypropylene non-woven fab...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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Abstract

The invention discloses a hemostatic polypropylene non-woven fabric and a preparation method thereof. The hemostatic polypropylene non-woven fabric comprises 26 to 50 parts of a polypropylene non-woven fabric, 16 to 25 parts of chitosan, 13 to 28 parts of polyvinyl alcohol, 12 to 25 parts of levofloxacin, 12 to 19 parts of acetic acid, 8 to 22 parts of sodium carbonate, 12 to 18 parts of sodium styrenesulfonate, 2 to 7 parts of N-vinyl-2-pyrrolidone, 3 to 8 parts of acrylamide, 1 to 8 parts of acrylic acid and 23 to 48 parts of deionized water. The hemostatic polypropylene non-woven fabric ofthe invention has a uniform pore diameter and is uniformly loaded with the antibacterial drug levofloxacin; the hemostatic polypropylene non-woven fabric can stably release the antibacterial drug under different in-vitro environments; and the hemostatic polypropylene non-woven fabric has good sustained-release properties and can be used as a wound dressing and a hemostatic material.

Description

technical field [0001] The invention belongs to the field of material chemistry, and relates to a functional nonwoven fabric material, in particular to a hemostatic polypropylene nonwoven fabric and a preparation method thereof. Background technique [0002] Chitosan (chitosan, CS) is a rich natural alkaline polysaccharide, which is the second largest biological resource after cellulose in nature. It has good biocompatibility, biodegradability, human affinity, Excellent properties such as antibacterial, hemostasis and promotion of wound healing. Chitosan nanofibrous membranes have broad application prospects in the fields of skin dressings, hemostatic materials, tissue engineering scaffolds, and drug release. [0003] Polyvinyl alcohol (PVA) is a water-soluble polymer with biodegradability and bioaffinity, which is non-toxic to the human body and is a good biomedical material. In view of the poor mechanical properties of pure chitosan fibers, the application as medical fib...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/24A61L15/20A61L15/42A61L15/44A61L15/46
Inventor 张俊武姚仟锋
Owner 苏州市苏真床垫有限公司
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