Application of Myricetin in Preparation of Anti-Adriamycin Cardiotoxicity Protection Preparation

A cardiotoxic and anti-doxorubicin technology, applied in the field of pharmacy, can solve problems affecting the physical and mental health of patients, myocardial cell damage, etc., and achieve the effects of high heat and chemical stability, strong scavenging ability, and resistance to chemical disturbances
CN107595802BActive Publication Date: 2021-04-23ZHEJIANG OCEAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG OCEAN UNIV
Publication Date
2021-04-23

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Abstract

The invention discloses the application of myricetin in the preparation of anti-adriamycin cardiotoxicity protection preparation. The invention also discloses anti-adriamycin cardiotoxicity protective microcapsules. The beneficial effects are: the anti-adriamycin cardiotoxicity protection preparation prepared by the present invention has a strong ability to scavenge oxygen free radicals, avoids myocardial cell membrane lipid peroxidation and damage to myocardial mitochondrial DNA, and can significantly reduce cardiomyocyte apoptosis ; The prepared microcapsules have higher thermal and chemical stability and can better resist chemical perturbations in the biological microenvironment.
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Description

technical field

[0001] The invention belongs to the field of pharmacy, and in particular relates to the application of myricetin in preparing anti-adriamycin cardiotoxicity protection preparations. Background technique

[0002] Doxorubicin is an anthracycline antitumor antibiotic, which can inhibit the synthesis of RNA and DNA. It has a broad antitumor spectrum and can kill tumor cells in various growth cycles. It is mainly applicable to acute and chronic leukemia, malignant lymphoma, breast cancer and other solid tumors. However, in the course of clinical application, it has a strong damage effect on cardiomyocytes and produces doxorubicin cardiotoxicity, which will seriously affect the physical and mental health of patients. Therefore, it is very necessary to find drugs that can reduce the cardiotoxicity of doxorubicin for its clinical application. Contents of the invention

[0003] The object of the present invention is to use myricetin for preparing anti-adriamycin c...

Claims

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