Method for preparing methoxyacetone by using microreaction device

A technology of a micro-reaction device and methoxyacetone, applied in the chemical industry, can solve the problems of incapable of continuous production automation, complex catalysts, expensive use, etc., and achieves the advantages of avoiding the use of complex catalysts, easy preparation process and low production cost. Effect

Active Publication Date: 2018-01-19
NANJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a method for preparing methoxyacetone by using a micro-reaction device, so as to solve the existing problems in the prior art that expensive and complex catalysts are used, the yield is low, there are many by-products, and continuous production is not possible. and low degree of automation

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  • Method for preparing methoxyacetone by using microreaction device

Examples

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Embodiment 1

[0029] Mix methanol and potassium hydroxide to obtain a methanol solution, the mass fraction of potassium hydroxide in the methanol mixture is 0.5wt%, then pump the propylene oxide and methanol solution into the micro-mixer in the micro-reaction device, and mix thoroughly The mixed system is pumped into the first microreactor in the microreactor for reaction. The molar ratio of propylene oxide to methanol is 1:3, the reaction temperature is 100°C, and the reaction residence time is 5min. The 1-methoxyl group produced by the reaction After the crude product of -2-propanol is neutralized by phosphoric acid and concentrated by flash evaporation, the pure product of 1-methoxy-2-propanol is obtained with a yield of 95%; 1-methoxy-2-propanol and sodium hypochlorite aqueous Pumped into the second microreactor in the microreaction device, wherein the pH of the sodium hypochlorite aqueous solution is 3 to 4 by using dilute hydrochloric acid, the mol ratio of 1-methoxyl-2-propanol and so...

Embodiment 2

[0031] Mix methanol and potassium hydroxide to obtain methanol solution, the mass fraction of potassium hydroxide in methanol mixed solution is 0.8wt%, then pump propylene oxide and methanol solution into the micro mixer in the micro reaction device, mix thoroughly The mixed system is pumped into the first microreactor in the microreaction device for reaction. The molar ratio of propylene oxide to methanol is 1:5, the reaction temperature is 120°C, and the reaction residence time is 7min. The 1-methoxyl group produced by the reaction After the crude product of -2-propanol is neutralized by phosphoric acid and concentrated by flash evaporation, the pure product of 1-methoxy-2-propanol is obtained with a yield of 99%; 1-methoxy-2-propanol and sodium hypochlorite aqueous solution Pumped into the second microreactor in the microreaction device, wherein the pH of the sodium hypochlorite aqueous solution is adjusted to be 3~4 by using dilute hydrochloric acid, the mol ratio of 1-meth...

Embodiment 3

[0033]Mix methanol and potassium hydroxide to obtain a methanol solution, the mass fraction of potassium hydroxide in the methanol mixture is 1wt%, then pump the propylene oxide and methanol solution into the micro-mixer in the micro-reaction device, and mix thoroughly The system is pumped into the first microreactor in the microreactor for reaction. The molar ratio of propylene oxide to methanol is 1:8, the reaction temperature is 130°C, and the reaction residence time is 8min. The 1-methoxy- The crude product of 2-propanol is neutralized by phosphoric acid and concentrated by flash evaporation to obtain the pure product of 1-methoxy-2-propanol with a yield of 96%; pump 1-methoxy-2-propanol and sodium hypochlorite aqueous solution Into the second microreactor in the microreaction device, wherein by using dilute hydrochloric acid to regulate the pH of sodium hypochlorite aqueous solution to be 3~4, the mol ratio of 1-methoxyl group-2-propanol and sodium hypochlorite is 1: 4, an...

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Abstract

The invention discloses a method for preparing methoxyacetone by using a microreaction device. The method comprises the following steps: mixing methanol with a basic catalyst to obtain a methanol solution; then pumping the methanol solution and epoxypropane into a micromixer in the microreaction device; sufficiently mixing and then introducing a mixed solution into a first microreactor in the microreaction device for reacting; after the reaction is ended, carrying out neutralizing and flash evaporation and concentration on a reaction solution to obtain 1-methoxy-2-propanol; pumping the 1-methoxy-2-propanol and an aqueous solution of sodium hypochlorite into a second microreactor in the microreaction device for reacting to obtain the methoxyacetone. According to the preparation method of the methoxyacetone, disclosed by the invention, the problems in the existing production can be overcome, the use of a complex catalyst is avoided, and the content of a byproduct is reduced; the production cost is low, the continuation degree of the process is high; the safety of the production process can be substantially improved; the quality of a product is improved.

Description

technical field [0001] The invention belongs to the field of chemical industry, and in particular relates to a method for preparing methoxyacetone by using a micro-reaction device. Background technique [0002] 1-methoxy-2-propanol, also known as propylene glycol monomethyl ether, has two groups with strong solubility in its chemical structure: ether bond and hydroxyl group. The former is hydrophobic and can dissolve hydrophobic compound; the latter is hydrophilic and can dissolve water-soluble substances. Therefore, propylene glycol ether is a versatile solvent with excellent performance, also known as a universal solvent. 1-methoxy-2-propanol has a faint ether smell, but no strong pungent smell, making it safer to use and can be used in many fields, such as high-grade paint solvents, printing ink viscosity regulators, metal cleaning agents, Auto water tank anti-icing fluid, etc. [0003] Alcohol ether compounds are a wide range of fine chemical products. Since the Europ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C45/30C07C49/175C07C41/03C07C43/13
Inventor 郭凯何伟方正李昕欧阳平凯
Owner NANJING UNIV OF TECH
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