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Skeleton type sulfamethoxazole sulfadiazine and trimethoprim sustained-release pellet and preparation method thereof

A technology of trimethoprim and sustained-release pellets is applied in the field of medicine, which can solve the problems of reducing the number of administrations, difficult to control the administration dosage, and complicated administration, so as to alleviate the toxic and side effects and optimize the clinical treatment effect. , the effect of maintaining effective blood drug concentration

Inactive Publication Date: 2018-02-09
LUOYANG RUIHUA ANIMAL HEALTH PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The technical problem solved by the present invention is to overcome the difficult control of the dosage of the existing bisulfamethoprim premix in application, the complicated administration and the nephrotoxicity of sulfonamides to the animal body after administration. Oxypridine sustained-release pellets are convenient for mixing or direct administration, and the number of administrations is reduced to 1-2 times a day, and after administration, a certain effective blood drug concentration can be maintained in the animal body for a long time, avoiding the need for re-administration. The emergence of peaks and valleys is beneficial to reduce the toxic and side effects of drugs, reduce the total dose of administration, and achieve the maximum drug effect with the least dose

Method used

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  • Skeleton type sulfamethoxazole sulfadiazine and trimethoprim sustained-release pellet and preparation method thereof
  • Skeleton type sulfamethoxazole sulfadiazine and trimethoprim sustained-release pellet and preparation method thereof
  • Skeleton type sulfamethoxazole sulfadiazine and trimethoprim sustained-release pellet and preparation method thereof

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Experimental program
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Embodiment 1

[0028] Embodiment 1 The ratio of raw and auxiliary materials of trimethoprim sustained-release pellets of the present invention.

[0029] The screening formula is according to the following ratio of raw materials in parts by weight, formula 1-formula 3.

[0030]

[0031]

[0032] Take the raw materials of the formula weight parts in the above table respectively, take sulfadiazine, sulfamethoxazole, trimethoprim, sucrose, polyethylene glycol 400, put them in a pulverizer and pulverize them and pass through an 80 mesh sieve, put them in a fluidized bed Boil at medium temperature for 20 minutes to mix the raw materials evenly, take another binder and dilute it with water, and then turn on the nozzle.

[0033] Take formula 4 and sulfamethoprim premix (100g: sulfadiazine 20g + sulfamethoxazole 20g + trimethoprim 8g) commonly used in clinical practice for pharmacodynamics test, through the change of drug concentration in serum within a certain period of time Analyze whether t...

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Abstract

The invention relates to an oral medicine sustained-release preparation and a preparation method thereof, in particular relates to a skeleton type sulfamethoxazole sulfadiazine and trimethoprim sustained-release pellet and a preparation method thereof, and belongs to the technical field of medicine. The skeleton type sulfamethoxazole sulfadiazine and trimethoprim sustained-release pellet comprisesa skeleton type sulfamethoxazole sulfadiazine and trimethoprim sustained-release pill core and a coating, wherein the sulfamethoxazole sulfadiazine and trimethoprim sustained-release pellet is prepared from sulfadiazine, sulfamethoxazole, trimethoprim, a diluent, adhesive, sodium carbonate, a skeleton material, a coating material and an anti-adhesion material according to a fluidized bed method.The sulfamethoxazole sulfadiazine and trimethoprim sustained-release pellet can fulfill the aims of reducing administration times, reducing the total dose of administration and increasing the recoveryrate through sustained release, and can optimize the clinical effect of sulfamethoxazole sulfadiazine and trimethoprim.

Description

technical field [0001] The invention relates to an oral medicine sustained-controlled delayed-release preparation and a preparation method thereof, in particular to a skeleton-type trimethoprim sustained-release pellet and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Trimethoprim is a compound preparation of sulfadiazine (SD), sulfamethoxazole (SMZ) and trimethoprim (TMP). [0003] Sulfadiazine (SD) is white or off-white crystal or powder; odorless, tasteless, gradually darkens when exposed to light. SD is slightly soluble in ethanol or acetone, almost insoluble in water; easily soluble in sodium hydroxide test solution or ammonia test solution, and soluble in dilute hydrochloric acid. Oral oral administration of SD is easy to absorb, reaches the peak blood concentration in 3-4 hours, the concentration in the cerebrospinal fluid can reach 70% of the blood concentration, the protein binding rate in the blood is abo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/505A61K31/635A61K9/50A61K47/02A61K47/32A61P31/04
Inventor 李新王永永李阳
Owner LUOYANG RUIHUA ANIMAL HEALTH PROD
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