Application of magnesium chloride solution to preparation of medicines for treating osteoarticular diseases

Abstract

The invention discloses the application of a solution containing magnesium chloride serving as an effective component to the preparation of medicines for treating osteoarticular diseases. The solutionis prepared by taking normal saline as a solvent, and the magnesium chloride concentration of the solution is 10 to 20 mmol / L. The osteoarticular diseases comprise articular cartilage injury disease,articular cartilage degenerative disease, arthritis disease and the like. According to the invention, the magnesium chloride solution can promote cartilage cell proliferation and cell activity, has the effects of inhibiting macrophagocyte from being polarized to the M1 state and promoting M2 polarization, can effectively control inflammatory reaction caused by the macrophagocyte, is favorable fortissue healing, has a good treatment effect on the osteoarticular diseases and can promote tissue repairing.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the use of magnesium chloride solution in the preparation of medicines for treating bone and joint diseases. Background technique [0002] The occurrence of bone and joint diseases often begins with synovial lesions, cartilage damage or degeneration; cartilage damage caused by taking certain anti-inflammatory and hormone drugs is also one of the main causes of many bone and joint diseases. Due to the damage of joint synovium and cartilage and the lack of joint synovial fluid, the joint bones lack the necessary protection, so that when the human body is active, the bones at the joints directly undergo severe and hard friction due to the lack of necessary "cartilage protection", causing The patient suffered from various symptoms such as joint pain, swelling, deformation, and hyperplasia of bone spurs. More importantly, if the immune system of human joints and organs is imbal...

AI Technical Summary

Problems solved by technology

Although it has been reported in the literature that a variety of Chinese herbal medicines combined with external application of magnesium chloride can be used to treat arthritis, because the compound preparation contains a variety of drugs, and no research has confirmed that magnesium chloride is the main active ingredient of the compound preparation

In addition, the main role of magnesium ions in external application is to promote tissue detumescence by adjusting osmotic pressure, and no research has confirmed that it can improve arthritis through skin absorption

In terms of route of administration, currently the main routes of administration of magnesium-related products are intravenous injection, intramuscular injection, oral administration, and external application, and there is no dosage form specifically for intra-articular injection

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