Method for preparing microfluidic channels in glass by simple hot-pressing process

A technology of microfluidic channel and hot-pressing process, which is applied in the directions of laboratory containers, chemical instruments and methods, laboratory utensils, etc. The effect of non-toxic pollution, simple and easy preparation method and mild reaction conditions
CN107790201AInactive Publication Date: 2018-03-13HENAN UNIVERSITY OF TECHNOLOGY
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
HENAN UNIVERSITY OF TECHNOLOGY
Publication Date
2018-03-13
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention discloses a method for preparing microfluidic channels in glass by a simple hot-pressing process. The method includes: designing a microfluidic channel pattern by AUTOCAD (auto computeraided design), and grinding and polishing glass to make surface roughness of the glass not larger than 50micron; inscribing the pattern on a nickel alloy substrate by laser direct writing, subjectinga normal glass slide to hot pressing treatment by a normal electric furnace and a pressure plate, aligning the nickel alloy substrate to the glass, putting the pressure plate, setting an appropriate heat procedure, and finally separating the nickel alloy substrate at the room temperature to finish glass based microfluidic channel preparation. Preparing the microfluidic channels 150micron in depthonly takes about 2.2h, low manufacturing cost and short period are realized, the process is simple, inner walls of the microfluidic channels are smooth and free of extra modification, and easiness inpopularization and utilization is achieved. The method has advantages that simplicity, feasibility, nontoxicity, freeness of pollution, environmental friendliness and easiness in technical mastering are realized, reaction is performed under conditions of the set heat procedure and pressure, and batch production can be realized.
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Description

technical field

[0001] The invention relates to the technical field of preparation of microfluidic biochip microchannels, in particular to a preparation method of glass-based microchannels. Background technique

[0002] Microfluidic chip has the characteristics of less sample consumption, small volume and fast analysis speed, and can realize high automation and integration. A dynamic instrumental approach platform. The main applications focus on large-scale, high-throughput, low-cost life science and analytical chemistry experiments, including single cell culture and analysis, stem cell manipulation and culture, single molecule biophysics, high-throughput cell and molecular biology screening Experimentation, drug discovery, high-throughput synthetic biology, high-throughput sequencing technology, single-cell genomics, etc.

[0003] At present, the materials used to make chips are glass and polymers. The biggest disadvantages of high molecular polymers including PDMS, PMMA...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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