Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of biological magnesium alloy with antibacterial function and preparation method thereof

A magnesium alloy and biological technology, which is applied in the design and manufacture of biological magnesium alloys, can solve the problems of surrounding tissue cytotoxicity, bacterial infection around the implant, and high local concentration, so as to avoid agglomeration and growth, and reduce component segregation , Improve the effect of mechanical properties

Inactive Publication Date: 2019-08-02
CENT SOUTH UNIV
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, existing research is limited to nano-TiO 2 Used as a surface coating or coating additive in bio-magnesium alloys, the surface coating can only make the bio-magnesium alloy have antibacterial effect at the initial stage of implantation, but after the coating breaks and falls off, bacterial infection is still prone to occur around the implant
Moreover, the higher content of TiO in the surface coating 2 May accumulate at the site of implantation resulting in excessive local concentrations, which can be toxic to surrounding tissue cells

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Nano TiO 2 powder and AZ91 magnesium alloy powder as raw materials, weighing 9.5g AZ91 magnesium alloy powder (particle size ~ 70μm) and 0.5g nano-TiO 2 Powder (particle size ~ 60nm), under the protection of argon, after ball milling for 6 hours at the rotor speed of the ball mill at 350rad / min, uniformly dispersed nano-TiO 2 / AZ91 mixed powder. Nano-TiO was prepared by SLM technology at a laser power of 90W, a scanning speed of 300mm / min, a spot diameter of 90μm, a scanning distance of 0.08mm, and a powder coating thickness of 0.1mm. 2 / AZ91 magnesium alloy.

[0026] The test found that nano-TiO 2 It can keep the structure stable during the SLM forming process, and evenly disperse on the magnesium alloy grain boundary as the second phase. Study on AZ91 Magnesium Alloy and Nano TiO by Bacteria Counting Method 2 / AZ91 magnesium alloy for antibacterial detection, that is, use 1×10 7 After co-cultivating cfu / mL Escherichia coli suspension for 24 hours, the bacterial ...

Embodiment 2

[0028] Nano TiO 2 powder and AZ91 magnesium alloy powder as raw materials, weighing 9.3g AZ91 magnesium alloy powder (particle size ~ 70μm) and 0.7g nano TiO 2 Powder (particle size ~ 60nm), under the protection of argon, after ball milling for 6 hours at the rotor speed of the ball mill at 350rad / min, uniformly dispersed nano-TiO 2 / AZ91 mixed powder. At 90W laser power, 300mm / min scanning speed, 0.5mm spot diameter, 0.08mm scanning distance, and 0.1mm powder coating thickness, nano-TiO was prepared by SLM technology. 2 / AZ91 magnesium alloy.

[0029]The test found that nano-TiO 2 It can keep the structure stable during the SLM forming process, and evenly disperse on the magnesium alloy grain boundary as the second phase. Study on AZ91 Magnesium Alloy and Nano TiO by Bacteria Counting Method 2 / AZ91 magnesium alloy for antibacterial detection, that is, use 1×10 7 After co-cultivating cfu / mL Escherichia coli suspension for 24 hours, the bacterial concentration of AZ91 ma...

Embodiment 3

[0031] Nano TiO 2 powder and AZ91 magnesium alloy powder as raw materials, weighing 9.7g AZ91 magnesium alloy powder (particle size ~ 70μm) and 0.3g nano TiO 2 Powder (particle size ~ 60nm), under the protection of argon, after ball milling for 6 hours at the rotor speed of the ball mill at 350rad / min, uniformly dispersed nano-TiO 2 / AZ91 mixed powder. Nano-TiO was prepared by SLM technology at a laser power of 90W, a scanning speed of 300mm / min, a spot diameter of 90μm, a scanning distance of 0.08mm, and a powder coating thickness of 0.1mm. 2 / AZ91 magnesium alloy.

[0032] The test found that nano-TiO 2 It can keep the structure stable during the SLM forming process, and evenly disperse on the magnesium alloy grain boundary as the second phase. Study on AZ91 Magnesium Alloy and Nano TiO by Bacteria Counting Method 2 / AZ91 magnesium alloy for antibacterial detection, that is, use 1×10 7 After co-cultivating cfu / mL Escherichia coli suspension for 24 hours, the bacterial ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to a bio-magnesium alloy with antibacterial function and a method for preparing the bio-magnesium alloy by laser selective melting technology. The bio-magnesium alloy with antibacterial function consists of a bio-magnesium alloy matrix and nano-TiO uniformly distributed in the magnesium alloy matrix. 2 Composition; In the bio-magnesium alloy with antibacterial function, nano-TiO 2 The mass percentage content is 3-7%. The preparation method is as follows: according to the design ratio, mix nano-TiO 2 Powder and bio-magnesium alloy powder, the prepared powder is placed in a ball mill, and the mixed powder is obtained by high-speed ball milling under a protective atmosphere; then, a bio-magnesium alloy with antibacterial function is prepared by selective laser melting under a protective atmosphere. The bio-magnesium alloy prepared by the invention has both excellent antibacterial performance and cell compatibility, improved mechanical properties and proper degradation rate. When used as an implant material, it has advantages over existing materials.

Description

technical field [0001] The invention relates to a bio-magnesium alloy with antibacterial function and a method for preparing the bio-magnesium alloy by using laser selective melting (SLM) technology, which belongs to the field of bio-magnesium alloy design and manufacture. Background technique [0002] In recent years, biomagnesium alloys have become a new generation of medical implant materials due to their good biocompatibility, mechanical properties and biodegradable properties. As a metal material, the fracture toughness of biomagnesium alloy is higher than that of bioceramic materials, and its elastic modulus and compressive yield strength are closer to human bone than other metal implant materials, which can effectively alleviate the damage caused by traditional metal implant materials. The stress shielding effect plays an important role in tissue repair and fracture healing. Moreover, bio-magnesium alloys are easy to corrode in the internal environment, so as to achi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C22C23/02C22C32/00C22C1/05B22F9/04B22F3/105B33Y10/00B33Y80/00A61L27/04A61L27/50
CPCA61L27/047A61L27/50C22C1/05C22C23/02C22C32/0036B22F9/04B33Y10/00B33Y80/00A61L2430/02B22F2009/043B22F2998/10B22F10/00B22F10/28B22F10/36B22F10/32Y02P10/25
Inventor 帅词俊高成德
Owner CENT SOUTH UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com