Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method for absorbable anti-infective hernia mesh

A hernia repair and anti-infection technology, applied in coatings, medical science, prostheses, etc., can solve problems such as increasing patient pain, various complications, and visceral adhesions, so as to reduce the incidence of complications, avoid inflammation, prevent The effect of visceral adhesions

Inactive Publication Date: 2018-03-27
武汉蓝普医品有限公司
View PDF0 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a method for preparing an absorbable anti-infective hernia repair sheet, so as to solve the existing technical problems that the hernia repair sheet will adhere to viscera after hernia repair surgery, cause various complications, and increase the suffering of patients.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] S1. Dissolve racemic polylactic acid with a molecular weight of 200,000 in ethyl acetate, stir it under airtight conditions to dissolve it completely, ultrasonically defoam, and set aside;

[0026] S2. Take chitosan with a molecular weight of 38,000 and dissolve it in 0.35mol / L acetic acid, stir and mix evenly under airtight conditions, ultrasonic defoaming, and set aside;

[0027] S3. Mix the solutions prepared in steps A and B, wherein the mass of chitosan: the total mass of the solution=2:100; the solution is poured on the flat plate, and evaporated into a film;

[0028] S4. Brush rice bran glue on the film prepared in step C, and stick the side coated with rice bran glue to the side of the polypropylene substrate to obtain the fibrous membrane hernia repair sheet.

Embodiment 2

[0030] S1. Take L-polylactic acid with a molecular weight of 300,000 and dissolve it in tetrahydrofuran, stir it under airtight conditions to dissolve it completely, ultrasonically defoam it, and set aside;

[0031] S2. Take chitosan with a molecular weight of 38,000 and dissolve it in citric acid of 0.5mol / L, stir and mix evenly under airtight conditions, ultrasonic defoaming, and set aside;

[0032] S3. Mix the solutions prepared in steps A and B, wherein the mass of chitosan: the total mass of the solution=2-6:100; the solution is poured on the flat plate, and evaporated to form a film;

[0033] S4. Brush rice bran glue on the film prepared in step C, and stick the side coated with rice bran glue to the side of the polypropylene substrate to obtain the fibrous membrane hernia repair sheet.

Embodiment 3

[0035] S1. Take L-polylactic acid with a molecular weight of 400,000 and dissolve it in acetone, stir it under airtight conditions to dissolve it completely, ultrasonically defoam it, and set aside;

[0036] S2. Take chitosan with a molecular weight of 38,000 and dissolve it in 0.7mol / L acetic acid, stir and mix evenly under airtight conditions, ultrasonic defoaming, and set aside;

[0037] S3. Mix the solutions prepared in steps A and B, wherein the mass of chitosan: the total mass of the solution=6:100; the solution is poured on the flat plate, and evaporated into a film;

[0038] S4. Brush rice bran glue on the film prepared in step C, and stick the side coated with rice bran glue to the side of the polypropylene substrate to obtain the fibrous membrane hernia repair sheet.

[0039] In the present invention, the polypropylene substrate has a single-layer network structure, is easily infiltrated by connective tissue, has little foreign body reaction, and has good tensile str...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of an absorbable anti-infection hernia repair sheet, which comprises a polypropylene base sheet, and a composite film composed of a degradable polymer material and a chitosan solution is arranged on the outside of the polypropylene base sheet. The patch is distributed by dissolving the degradable polymer material in the polymer material solvent, dissolving chitosan in the organic acid, mixing the two solutions, pouring them on a flat plate, and evaporating to form a thin film; Brush rice bran glue, stick the side coated with rice bran glue to one side of the polypropylene base sheet, and get the fibrous membrane hernia repair sheet. In the present invention, the polypropylene substrate has a single-layer network structure, is easily infiltrated by connective tissue, has little foreign body reaction, and has good tensile strength. Polylactic acid can have good degradation performance, chitosan has good moldability and biocompatibility, and can promote wound healing. Rice bran gum is also a biodegradable binder. The invention can prevent the viscera from sticking to the patch, reduce the probability of complications, and has good practical value.

Description

technical field [0001] The invention relates to a hernia repair sheet, in particular to a preparation method of an absorbable anti-infection hernia repair sheet. Background technique [0002] Hernia is a certain organ or tissue in the human body that leaves its normal anatomical position and enters another part through a congenital or acquired weak point, defect or hole, and may occur at any age. Traditional repair methods are prone to recurrence, Long repair time, postoperative pain, etc. are certain and are not adopted, and tension-free repair surgery using mesh methods emerged as the times require. Tension-free hernia repair surgery uses a mesh to repair the hernia gap, which avoids the disadvantages of postoperative pain and easy recurrence of traditional hernia repair surgery. At present, patches made of polyester and polypropylene materials are commonly used clinically. Polypropylene patch has excellent chemical stability and tissue compatibility, and can promote the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/34A61L27/36A61L27/16A61L27/58A61L27/54
CPCA61L27/34A61L27/16A61L27/36A61L27/54A61L27/58A61L2300/232A61L2300/404A61L2420/06C08L67/04C08L5/08C08L23/12
Inventor 沈乔
Owner 武汉蓝普医品有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com