A pressure steam sterilization chemical indicator and preparation method thereof

Abstract

The invention discloses a pressure steam sterilization chemical indicator and a preparation method thereof, belonging to the field of moist heat sterilization indication. The chemical indicator mainly includes two parts: chemical indicator ink and substrate. The weight composition of the active ingredients of the pressure steam sterilization chemical indicator is: 1-10 parts of tetrazolium salt, 5-20 parts of system stabilizer, 50-70 parts of solvent, 10-20 parts of binder, and 5 parts of alkaline auxiliary. ‑20 servings, and 1‑10 servings of antioxidants. The above active ingredients are mixed and stirred to obtain a uniform and viscous composition, which is then sent to a grinder for grinding to form a uniformly dispersed indicator ink. The indicator ink is printed on the substrate by flexographic printing, and after drying, the chemical indicator is obtained by pressure steam sterilization. The pressure steam sterilization chemical indicator provided by the present invention is exposed to the saturated pressure steam conditions of 121 ° C, 132 ° C and 134 ° C, and the color of the indicating ink changes from colorless to dark, which can be determined by the color depth of color development. Determine whether the sterilization is qualified.

Description

technical field [0001] The invention belongs to the field of damp heat sterilization indicators, in particular to a pressure steam sterilization chemical indicator and a preparation method thereof. Background technique [0002] For the sterilization method of reusable medical devices, pressure steam sterilization is the most commonly used method in medical institutions at all levels. This sterilization method is also the most reliable and widely used. For pressure steam sterilization, biological indicators are the gold standard for monitoring the sterilization effect, but due to factors such as high price, long incubation time, and differences between different batches, their large-scale application is limited. Therefore, in view of the advantages of chemical sterilization monitoring indicators that do not require cultivation and can quickly interpret the results by visually identifying the color change of the chemical indicator, chemical indicators are widely used in the ou...

AI Technical Summary

Problems solved by technology

[0004] (1) Using heavy metals as formula components, there is a risk of foreign body infection after surgery;

[0005] (2) Using metal salt and sulfur powder as the core components, the ink has a high grinding viscosity and is not easy to grind and print;

[0006] (3) Multivalent metal sulfides in an environment containing a small amount of oxidizing agents, such as hydrogen peroxide, can easily cause the active components of the chemical indicator to fade or change color after steam sterilization

[0007] (4) Poor weather resistance, unused indicators are easy to react with redox agents or acid-base in the environment during storage, causing the indicators to fade or change color