The invention discloses a hospital 
wastewater comprehensive treatment device with zero 
sludge discharge and a treatment method thereof. The device is composed of a 
chlorine dioxide disinfection tank,a three-grid 
septic tank, an adjusting tank, a closed 
ultraviolet sterilizer, a multistage bio-
chemical tank and a 
chlorine dioxide disinfection tank which are sequentially connected in series, and further comprises a 
waste gas treatment module; a 
cutting pump is arranged in the adjusting tank; the 
waste gas treatment module is composed of 
plasma equipment and 
activated carbon adsorption equipment; wherein the multi-stage biochemical tank is formed by connecting a multi-stage unit A, a multi-stage unit O and a 
precipitation unit in series, part of 
sludge at a 
sludge outlet of a 
precipitation unit flows back to the front section of the multi-stage unit A through a sludge return pump and a sludge return 
pipe, and the rest sludge is discharged to the water inlet section of the three-grid 
septic tank as residual sludge; by adopting the treatment method disclosed by the invention, the 
effluent quality is superior to the standard of 
Discharge Standard of 
Water Pollutants for Medical Organization (GB18466-2016), the treatment method has the advantages that residual sludge, grid 
slag and the like are not generated, and the risk of bacterial infection of 
aerosol, sludge, grid 
slag, 
waste gas and the like is avoided.