Application of umbilical cord mesenchymal stem cell medicine in promoting skin wound healing

A stem cell and wound healing technology, applied in the application field of umbilical cord mesenchymal stem cell drugs in promoting skin wound healing, can solve the problem of low ability of stem cells to repair wound healing, and achieve the goal of promoting the growth of epidermal cells, increasing the magnetic susceptibility, Anti-aging effect

Inactive Publication Date: 2018-04-06
深圳市莱利赛生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides an application of umbilical cord mesenchymal stem cell medicine in promoting skin wound healing to solve the technical problem of low ability of stem cells to repair wound healing in complex in vivo environment

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] An application of umbilical cord mesenchymal stem cell medicine in promoting skin wound healing, said umbilical cord mesenchymal stem cell medicine comprises: 8% umbilical cord mesenchymal stem cell, 1% human fibroblast, 7% phospholipid, 7% cholesterol, 2% nano magnet, 2% compound electrolyte, 6% small molecule active peptide, 3% Chinese medicine extract, 2% nutritional complex, 0.5% nicotinamide mononucleotide (NMN), 0.4% hypoxia induction Factor, 0.3% human plasminogen activator inhibitor 1, 0.8% transforming growth factor, 1% human platelets, 0.5% sodium hyaluronate, 5% phosphate buffer, 8% normal saline, 0.3% stabilizer, 0.2 % antioxidant, 0.3% antibacterial agent, 0.5% osmotic pressure regulator, and the balance is double distilled water; wherein, the nutritional complex is composed of vitamin E, vitamin C, vitamin B3, marine polysaccharide, α-linolenic acid in mass percentage Formed in a ratio of 2:1:1:2:3, vitamin E can prolong cell life, prevent lipid deposition a...

Embodiment 2

[0036] An application of umbilical cord mesenchymal stem cell medicine in promoting skin wound healing, said umbilical cord mesenchymal stem cell medicine comprises: 9% umbilical cord mesenchymal stem cell, 2% human fibroblast, 8% phospholipid, 8% cholesterol, 3% nano magnet, 3% compound electrolyte, 7% small molecule active peptide, 4% Chinese medicine extract, 3% nutritional complex, 0.8% nicotinamide mononucleotide (NMN), 1.1% hypoxia induction Factor, 0.75% human plasminogen activator inhibitor 1, 1.2% transforming growth factor, 1.5% human platelets, 1% sodium hyaluronate, 6% phosphate buffer, 9% saline, 0.4% stabilizer, 0.3 % antioxidant, 0.4% antibacterial agent, 0.8% osmotic pressure regulator, and the balance is double distilled water; wherein, the nutritional complex is composed of vitamin E, vitamin C, vitamin B3, marine polysaccharide, α-linolenic acid in mass percentage Formed in a ratio of 2:1:1:2:3, vitamin E can prolong cell life, prevent lipid deposition and l...

Embodiment 3

[0048]An application of umbilical cord mesenchymal stem cell medicine in promoting skin wound healing, said umbilical cord mesenchymal stem cell medicine comprises: 10% umbilical cord mesenchymal stem cell, 3% human fibroblast, 9% phospholipid, 9% cholesterol, 4% nano magnet, 4% compound electrolyte, 8% small molecule active peptide, 5% Chinese medicine extract, 4% nutritional complex, 1% nicotinamide mononucleotide (NMN), 1.8% hypoxia induction Factor, 1.2% human plasminogen activator inhibitor 1, 1.5% transforming growth factor, 2% human platelets, 1.5% sodium hyaluronate, 7% phosphate buffer, 10% normal saline, 0.5% stabilizer, 0.4 % antioxidant, 0.5% antibacterial agent, 1% osmotic pressure regulator, and the balance is double distilled water; wherein, the nutritional complex is composed of vitamin E, vitamin C, vitamin B3, marine polysaccharide, α-linolenic acid in mass percentage Formed in a ratio of 2:1:1:2:3, vitamin E can prolong cell life, prevent lipid deposition an...

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Abstract

The invention discloses an application of an umbilical cord mesenchymal stem cell medicine in promoting skin wound healing and belongs to the technical field of biological medicines. Umbilical cord mesenchymal stem cells and human fibroblasts induced and differentiated by the umbilical cord mesenchymal stem cells are taken as medicine bodies, the target ability of the medicine is improved throughbonding of small molecular active peptides and medicine-carrying liposome and addition of magnetic particles to the liposome, besides, cells can be supplemented with magnetism, cell activity can be improved, aging can be delayed, and epidermal cell growth is facilitated. An injection is magnetized before injection, the magnetic susceptibility of the injection is increased through a compound electrolyte, the magnetized injection can activate cells in the medicine and cells in the human body, and the medicine effect and the self-healing capacity can be improved. In short, the medicine is applicable to chronic wounds which cannot heal easily and free of toxicity and risks.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of umbilical cord mesenchymal stem cell medicine in promoting skin wound healing. Background technique [0002] Skin wound repair is a complex choreographed process that is activated upon injury and includes multicellular overlapping and coordinated phases of inflammation, angiogenesis and granulation tissue formation, re-epithelialization and fibroproliferation or matrix formation and repair. Reduced proinflammatory cytokines, impaired neovascularization, or impaired leukocyte recruitment may disrupt and delay wound healing. Despite the wide range of effective wound dressings, ointments, and instruments currently in use, wound healing remains a clinical challenge. Chronic wounds represent an increasingly prevalent and costly public health problem, with improved emergency care, people living longer and consequently a growing number of patients suf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/28A61K38/02A61K9/08A61K47/02A61P17/02A61P3/10A61K35/33A61K31/7048A61K31/353A61K31/12A61K31/7024A61K31/05A61K31/355A61K31/375A61K31/455A61K31/715A61K31/202
CPCA61K9/0009A61K9/0019A61K9/08A61K31/05A61K31/12A61K31/202A61K31/353A61K31/355A61K31/375A61K31/455A61K31/7024A61K31/7048A61K31/715A61K35/28A61K35/33A61K38/02A61K47/02A61K2300/00
Inventor 宋芸娟胡士庶张治国
Owner 深圳市莱利赛生物科技有限公司
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