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Chemical-crosslinking-based cellulose-chitosan composite dressing and preparation method thereof

A chemical cross-linking and cellulose technology, applied in medical science, absorbent pads, bandages, etc., can solve the problems of liquid absorption, poor air permeability, secondary infection of wounds, difficult to clean and remove, etc., to achieve large liquid absorption and avoid Secondary pollution and injury, and the effect of avoiding wound infection

Inactive Publication Date: 2018-04-20
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

First, most composite materials are membrane materials, which have poor liquid absorption and air permeability
The second is that the composite methods are mostly physical blending, dipping and coating, etc. The combination between cellulose and chitosan is only based on physical effects, and the mechanical properties are poor. It is easy to fall off the residue during use, and it is difficult to clean and remove the residue in the wound. secondary infection of the wound
The third is a small number of cellulose-chitosan composite materials prepared by chemical crosslinking using small molecule crosslinking agents such as epichlorohydrin, glutaraldehyde, and genie. Unreacted small molecule crosslinking agents tend to remain in the material. Then, small molecules dissolve during use, causing damage to the cells at the wound

Method used

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  • Chemical-crosslinking-based cellulose-chitosan composite dressing and preparation method thereof
  • Chemical-crosslinking-based cellulose-chitosan composite dressing and preparation method thereof
  • Chemical-crosslinking-based cellulose-chitosan composite dressing and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028] (1) 0.055g chitosan (deacetylation degree is 85%, viscosity is 200Pa.s) is dissolved in 1% acetic acid aqueous solution and obtains concentration and is 1.1wt% chitosan solution, above-mentioned chitosan solution is mixed with 5g wood Pulp cellulose micron wire suspension (mass fraction 1.1wt%) is mixed to form a mixed solution, 0.11g 3-(2,3-epoxypropoxy) propyl trimethoxysilane is added in the mixed solution, at room temperature Under neutral conditions, magnetically stirred for 2 h to obtain a mixed suspension.

[0029] (2) Freeze the mixed suspension obtained in step (1) in liquid nitrogen, and then put it into a freeze dryer at a freeze-drying temperature of -58°C, freeze-dry for 24 hours, take it out and place it in a vacuum oven at 110°C for baking Bake for 30 minutes, wash with water for 3 times, wash with ethanol for 2 times, and wash with acetone for 3 times, and place in a vacuum oven to dry at 50°C for 6 hours to obtain a cellulose-chitosan composite dressing...

Embodiment 2

[0032] (1) Dissolve 0.066g (specific quality) chitosan (deacetylation degree is 95%, viscosity is 400Pa.s) in 1% acetic acid aqueous solution to obtain a concentration of 1.1wt% chitosan solution, the above chitosan Polysaccharide solution is mixed with 4g wood pulp cellulose micron wire suspension (mass fraction 1.1wt%) to form a mixed solution, and 0.055g 3-(2,3-glycidoxy) propyltriethoxysilane is added to In the mixed solution, under neutral conditions at room temperature, magnetically stirred for 2 h to obtain a mixed suspension.

[0033] (2) Freeze the mixed suspension obtained in step (1) in liquid nitrogen, and then put it into a freeze dryer at a freeze-drying temperature of -58°C, freeze-dry for 36 hours, take it out and bake it in a vacuum oven at 120°C Dry for 10 minutes, wash twice with water, twice with ethanol, and three times with acetone, and dry in a vacuum oven at 60°C for 4 hours to obtain a cellulose-chitosan composite dressing based on chemical crosslinkin...

Embodiment 3

[0036] (1) 0.077g chitosan (deacetylation degree is 90%, viscosity is 100Pa.s) is dissolved in 1% acetic acid aqueous solution and obtains concentration and is 1.6wt% chitosan solution, above-mentioned chitosan solution is mixed with 3g wood Pulp cellulose micron line suspension (mass fraction 1.4wt%) is mixed to form a mixed solution, 0.22g 3-(2,3-glycidoxy) propylmethyl dimethoxysilane is added in the mixed solution, Under neutral conditions at room temperature, magnetically stirred for 2 h to obtain a mixed suspension.

[0037](2) Freeze the mixed suspension obtained in step (1) in liquid nitrogen, and then put it into a freeze dryer at a freeze-drying temperature of -58°C, freeze-dry for 24 hours, take it out and place it in a vacuum oven at 120°C for baking Bake for 10 minutes, wash twice with water, twice with ethanol, and three times with acetone, and dry in a vacuum oven at 60°C for 3 hours to obtain a cellulose-chitosan composite dressing based on chemical crosslinkin...

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Abstract

The invention relates to a chemical-crosslinking-based cellulose-chitosan composite dressing and a preparation method thereof. The composite dressing comprises a silicane epoxide coupling agent, cellulose and chitosan or a chitosan derivative and has a uniform porous meshy structure, and the chitosan or the chitosan derivative uniformly coats the surface of a cellulose skeleton through crosslinking of the silicane epoxide coupling agent. The preparation method comprises the following steps: synthesizing a mixed suspension; and synthesizing the chemical-crosslinking-based cellulose-chitosan composite dressing. The preparation method is simple, easy to operate, low in cost and environmentally friendly. The obtained chemical-crosslinking-based cellulose-chitosan composite dressing has favorable mechanical property and toughness, is big in fluid absorption quantity and excellent in air permeability, prevents skin cells at a wound from being injured by digestion of small molecules in the using process, can promote blood coagulation and avoid wound infection, and therefore, has a wide application prospect in the medical dressing field.

Description

technical field [0001] The invention belongs to the field of medical dressings and preparation thereof, in particular to a chemically cross-linked cellulose-chitosan composite dressing and a preparation method thereof. Background technique [0002] As the largest organ of the human body, the skin is an important barrier to protect internal tissues and organs from external environmental disturbances and stimuli, and to maintain the balance of the internal environment of the human body. If the skin is damaged and not healed in time, it will cause wound inflammation or other pathological changes. Medical dressings are materials that can effectively protect wounds and promote wound healing. An ideal medical dressing should have the functions of controlling wound exudate, avoiding wound infection, keeping the wound moist and promoting wound healing. [0003] Cellulose is the most abundant natural polymer in nature. Because of its good biocompatibility and biodegradability, it h...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/42C08J3/24C08L1/02C08L5/08
CPCA61L15/28A61L15/42A61L15/425A61L2300/404A61L2300/418A61L2300/80C08J3/246C08J2301/02C08J2305/08C08J2401/02C08J2405/08C08L1/02C08L5/08
Inventor 隋晓锋成欢姜雨佳王碧佳毛志平徐红张琳萍钟毅
Owner DONGHUA UNIV