Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of chlortetracycline hydrochloride soluble powder and preparation method thereof

A chlortetracycline hydrochloride, soluble technology, applied in the field of chlortetracycline hydrochloride soluble powder and its preparation, can solve the problems of preparation stability, treatment effect, poor long-term stability, and chlortetracycline instability, etc., to improve the bioavailability of drugs High degree, prevention of oxidative discoloration, excellent therapeutic effect

Active Publication Date: 2020-09-29
PUCHENG CHIA TAI BIOCHEM
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently commercially available chlortetracycline hydrochloride soluble powder, due to the hygroscopicity of excipients, compatibility with chlortetracycline, etc., lead to instability of chlortetracycline, increased impurity content, easy to change color, which affects the stability of the preparation and the later stage. The therapeutic effect of the
[0003] Adopt aureomycin hydrochloride as raw material in Chinese patent CN104622811A, by adding lauryl sulfate sodium salt and ethylenediaminetetraacetic acid disodium salt, have improved the absorption rate and the bioavailability of aureomycin principal agent, but the product Long-term stability is still poor

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of chlortetracycline hydrochloride soluble powder and preparation method thereof
  • A kind of chlortetracycline hydrochloride soluble powder and preparation method thereof
  • A kind of chlortetracycline hydrochloride soluble powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0034] The present invention also provides the preparation method of the chlortetracycline hydrochloride soluble powder described in the above technical scheme, comprising the following steps:

[0035] Weighing the raw materials according to the parts by mass, and pulverizing the raw materials respectively;

[0036] mixing the pulverized raw material with water to obtain a raw material aqueous solution;

[0037] The raw material aqueous solution is vacuum freeze-dried and granulated sequentially to obtain aureomycin hydrochloride soluble powder.

[0038] In the present invention, the raw materials are weighed according to the stated parts by mass, and the raw materials are respectively pulverized. In the present invention, the particle size of the pulverized raw material is preferably 60-100 mesh, more preferably 80-100 mesh.

[0039] After the pulverized raw material is obtained, the present invention mixes the pulverized raw material with water to obtain a raw material aqu...

Embodiment 1

[0049] A chlortetracycline hydrochloride soluble powder is made from the following raw materials in weight ratio: carbomer 6kg, glycine 30kg, hydroxypropyl-β-cyclodextrin 30kg, sodium bisulfite 0.3kg, aureomycin hydrochloride 10kg , citric acid 23.7kg.

[0050]The preparation method of the above-mentioned chlortetracycline hydrochloride soluble powder comprises the following steps: weighing each raw material according to weight percentage, pulverizing and sieving the raw materials respectively, to obtain pulverized raw materials with a particle size of 80 mesh. Then, the pulverized carbomer, glycine, hydroxypropyl-β-cyclodextrin, sodium bisulfite, chlortetracycline hydrochloride, and citric acid were sequentially dissolved into the aqueous solution, and the vortex oscillator was used to shake and dissolve for 30 minutes. It is dried by a vacuum freeze dryer and granulated to obtain the final product. The vacuum degree of the vacuum freeze-drying machine is -0.06Pa, the vacuum...

Embodiment 2

[0052] A chlortetracycline hydrochloride soluble powder is made from the following raw materials in weight ratio: carbomer 7kg, glycine 30kg, hydroxypropyl-β-cyclodextrin 25kg, sodium bisulfite 0.3kg, chlortetracycline hydrochloride 20kg , citric acid 17.7kg.

[0053] The preparation method of the chlortetracycline hydrochloride soluble powder includes the following steps: weighing each raw material according to the weight percentage, pulverizing and sieving the raw materials respectively, to obtain the pulverized raw materials with a particle size of 100 mesh. Then, the pulverized carbomer, glycine, hydroxypropyl-β-cyclodextrin, sodium bisulfite, chlortetracycline hydrochloride, and citric acid were sequentially dissolved into the aqueous solution, and the vortex oscillator was used to shake and dissolve for 20 minutes. It is dried by a vacuum freeze dryer and granulated to obtain the final product. The vacuum degree of the vacuum freeze-drying machine is -0.07Pa, the vacuum...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle size (mesh)aaaaaaaaaa
particle size (mesh)aaaaaaaaaa
particle size (mesh)aaaaaaaaaa
Login to View More

Abstract

The invention provides a chlortetracycline hydrochloride soluble powder and belongs to the technical field of veterinary drugs. The chlortetracycline hydrochloride soluble powder is prepared from, bymass, 10-50 parts of chlortetracycline hydrochloride, 5-10 parts of carbomer, 5-25 parts of citric acid, 20-40 parts of glycine, 0.1-0.5 part of sodium hydrogen sulfite and 10-40 parts of hydroxypropyl-beta-cyclodextrin. The invention also provides a preparation method of the chlortetracycline hydrochloride soluble powder. The preparation method includes the steps of weighing the above raw materials by mass, and respectively crushing the raw materials; mixing the crushed raw materials with water and shaking to obtain raw material aqueous solution; drying the raw material aqueous solution andgranulating to obtain the chlortetracycline hydrochloride soluble powder. The chlortetracycline hydrochloride soluble powder prepared by the method has good stability and good solubility, and treatment effects are obviously better than that of the traditional chlortetracycline hydrochloride soluble powder.

Description

technical field [0001] The invention relates to the technical field of veterinary drugs, in particular to a chlortetracycline hydrochloride soluble powder and a preparation method thereof. Background technique [0002] Chlortetracycline hydrochloride, also known as chlortetracycline hydrochloride, has the same antibacterial spectrum as tetracycline, and its curative effect on penicillin-resistant Staphylococcus aureus is slightly stronger than tetracycline. Now it is mainly used to treat conjunctivitis, trachoma, etc. Currently commercially available chlortetracycline hydrochloride soluble powder, due to the hygroscopicity of excipients, compatibility with chlortetracycline, etc., lead to instability of chlortetracycline, increased impurity content, easy to change color, which affects the stability of the preparation and the later stage. have a great influence on the treatment effect. [0003] Adopt aureomycin hydrochloride as raw material in Chinese patent CN104622811A, b...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K31/65A61K47/40A61K47/32A61K47/18A61K47/12A61P31/04A61P27/02
CPCA61K9/145A61K9/146A61K31/198A61K31/65A61K2300/00
Inventor 陈浩然李俊冯献于庭堂许意锋陈杰郭红伟吴新芝李春荣
Owner PUCHENG CHIA TAI BIOCHEM
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com